ACTA NEUROPHARMACOLOGICA

Neuroprotective Effect of Mailuoning on MCAO Rats and Its Antioxidant Mechanism

YANG Jie，LIU Fu-jia，TIAN Zi-xia，WANG Le-le，XIE Xin-mei，PANG Xiao-bin

2017, 7 (4): 1-7. DOI: 10.3969/j.issn.2095-1396.2017.04.001

Abstract ( 996 )

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Objective：To investigate the antioxidant mechanism of mailuoning on MCAO rats. Methods：18 adult SD rats were randomly divided into control group，MCAO group and mailuoning group，6 rats in each group. A rat middle cerebral artery occlusion （MCAO） model was established by suture method，ischemic 2 h and reperfusion 24 h. 2% 2， 3，5-triphenyltetrazolium chloride （TTC） was used to measure the cerebral infarct volume in rat. The content of reactive oxygen species （ROS） were determined by fluorescence spectrometry. The contents of malondialdehyde （MDA） and glutathione （GSH） in brain tissue were determined by absorbance method. The expression of cysteinyl aspartate specific proteinase （caspase-3），B-cell lymphoma-2 associated X protein （Bax），B-cell lymphoma-2 （Bcl-2） were measured by Western Blot. Results：Mailuoning could significantly decrease the neurological function of MCAO rats and decrease the volume of cerebral infarction. Mailuoning could inhibit the production of ROS and the formation of MDA，meanwhile increase the level of GSH in brain tissue. Mailuoning could also inhibit the expression of caspase-3，Bax，however，increase the expression of Bcl-2. Conclusion：The protective effect of mailuoning on MCAO rats may be related to its inhibition of oxidative stress and apoptosis.

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Progress on Pathophysiology and Animal Models of Depression

ZHANG Kuo，YANG Jing-yu，WU Chun-fu

2017, 7 (4): 8-16. DOI: 10.3969/j.issn.2095-1396.2017.04.002

Abstract ( 256 )

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Depression is a common recurrent psychiatric disorder，which has severely affected quality of human life. So far，the pathogenesis of depression is still unknown and awaits clarification. This paper is a summary of the pathophysiology and animal models of depression，and provides reference for the treatment of depression and the evaluation of antidepressant drugs.

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Progress in Research of Brain Targeting Ligand for Nano-scale Drug Delivery Systems

REN Jing，ZHANG Dan-shen

2017, 7 (4): 17-25. DOI: 10.3969/j.issn.2095-1396.2017.04.003

Abstract ( 255 )

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Blood-cerebrospinal fluid barrier hinders the treatment of brain diseases，while targeted agents can not only selectively concentrate on the foci，but also increases the concentration of drugs and thereby reducing the toxicity and side effects，which popularly directs the treatment of brain diseases nowadays. This paper summarizes several brain target ligands applied broadly and their delivery strategies over the last five years，involving drug-carrying nanoparticles that transported to the brain by means of receptor-mediated，vector-mediated，and trans-cell-swallowing，which makes it possible to accumulate drugs in the brain，and needs to be prospectively researched and developed.

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The Mechanism of Dexmedetomidine and Its Application in Clinical Anesthesia

YUAN Li，WANG Hui-rong，TENG Jin-liang

2017, 7 (4): 26-30. DOI: 10.3969/j.issn.2095-1396.2017.04.004

Abstract ( 196 )

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Alpha 2- adrenergic receptor agonist has sedative，anti-anxiety，hypnotic and analgesic effects. Dexmedetomidine （Dex） is a new，potent and highly selective alpha 2- adrenergic receptor agonist.The present study showed that Dex could reduce the sedative and opioid dose，stabilize hemodynamics，and had the effects on anti-inflammation and organ protection，anti-shaking and salivation as well as other pharmacological properties in a wide range of clinical applications. Dex is considered to be a safe and effective adjuvant，or in single use of therapeutic agent in clinical anesthesia，it has a broad application prospects. From the mechanism of Dex，preoperative，intraoperative nerve block and spinal anesthesia，general anesthesia and postoperative adjuvant drug use，organ protection，ICU sedation etc. This article reviews its application in clinical anesthesia，and provide a theoretical basis for the clinical application and basic research of Dex.

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Research Progress of Traditional Chinese Medicine in Parkinson’s Disease

WAN Ye，GUO Chun-yan，LI Yong-min

2017, 7 (4): 36-42. DOI: 10.3969/j.issn.2095-1396.2017.04.006

Abstract ( 264 )

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Parkinson’s disease is an age-related neurodegenerative disease in the elderly. In recent years，the research of traditional Chinese medicine in the field of Parkinson’s disease has a certain prospects. This paper provides a summarization of current research progress of phenylpropanoids，sterides，terpenoids and volatile oil，flavonoids alkaloids on Parkinson’s disease.

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Study on the Neuroprotective Effects of Phytoestrogens in Alzheimer’s Disease

WANG Cui, GUO Tong-lin, SHEN Li-xia

2017, 7 (4): 43-52. DOI: 10.3969/j.issn.2095-1396.2017.04.007

Abstract ( 217 )

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Phytoestrogen （PE） is a type of plant component that is widely found in traditional Chinese medicine and has similar bioactivity of estrogen. It has been widely acknowledged about the role of phytoestrogens in the prevention and treatment of cardiovascular diseases，osteoporosis， tumors，and improvement postmenopausal syndrome in women. In recent years，more and more studies have shown that phytoestrogens play a protective role in the prevention and treatment of Alzheimer’s disease. Because they are widely derived from plants，and have no obvious side effects，concomitantly can be used as preventive health products，making phytoestrogens have a wide range of applications and prospects. This text reviews the source，classification，biological activity of phytoestrogens，and their pharmacological effects on improving learning and memory function， reducing the production of β-amyloid，antagonize the toxicity of β-amyloid and enhancing the function of cholinergic neurons ，the anti-oxidative stress and the neuroprotective effect in eliminating free radicals in Alzheimer’s disease，as well as the mechanism of phytoestrogen exerting neuroprotective effect through direct genomics and non-genomic effects. It provides new ideas and strategies for the development of Alzheimer’s disease prevention and treatment drugs making it a promising alternative to estrogen.

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