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    16 October 2025, Volume 15 Issue 5 Previous Issue   

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    Research on the Preparation Process of Wenyang Huazhuo- Pellet Under the Guidance of Intra-Hospital Preparation Filing System
    2025, 15 (5):  1.  DOI: 10.3969/j.issn.2095-1396.2025.05.001
    Abstract ( 23 )   PDF (1056KB) ( 19 )  
    Objective: To investigate the preparation process of zhongyu-pellet. Methods: Single-factor and orthogonal experimental methods were used to explore the extraction and pelletizing processes. The optimal extraction and pelletizing processes were determined and validated through three pilot-scale batches. Results: The optimal preparation processes were determined. Extraction process: Take the prescribed medicinal materials, add water for extraction three times (1.5 hours each time), using 10 times the amount of water for the extractions. Pelletizing process: The extract is dried at 70℃ , and maltodextrin is used as the excipient. During granulation, a 3:1 ratio of dry extract powder to excipient is mixed, with the addition of 80% ethanol (17.5 mL). The resulting granules are then vacuum-dried at 80℃ for 3 hours. Conclusion: The optimal extractions for the zhongyu-pellet were successfully determined.
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    A Study on the Timing of Performing Endoscopic Examination Under Local Anesthesia for Patients with Acute Upper Gastrointestinal Bleeding by Administering Dyclonine Hydrochloride Mucilage Gel Orally
    YU Li-hong, ZENG qin, ZHANG Ke-yue, WANG Fan-fan, HUANG Jie-qiong, CHEN Hui-yi, XUE Ying, CHEN Bin
    2025, 15 (5):  10.  DOI: 10.3969/j.issn.2095-1396.2025.05.002
    Abstract ( 22 )   PDF (1049KB) ( 7 )  
    Objective: Acute upper gastrointestinal bleeding is a common clinical emergency, which can be life-threatening in severe cases and should be paid close attention to Prompt diagnosis and treatment are critical, and previous guidelines recommend emergency gastroscopy within 24 hours. To explore whether gastroscopy within 12 hours after admission is a better time for AUGIB examination. Methods: A retrospective analysis was conducted on 244 patients who visited our emergency internal medicine department and received local anesthesia under gastroscopy from August 2021 to August 2024 (patients with AUGIB during gastroscopy examination). The patients were divided into two groups based on the time from emergency visit to local anesthesia under gastroscopy: the emergency gastroscopy group (within 12 h) and the elective gastroscopy group (after 12 h). The general clinical data, endoscopic diagnosis results, interventional embolization rate, surgical rate, blood transfusion volume, ICU hospitalization rate, average hospital stay, hospitalization cost, and mortality rate were compared between the two groups. Results: The hospitalization rate of intensive care unit (ICU) in the emergency gastroscopy group was higher than that in the elective gastroscopy group (P<0.05). There were no statistically significant differences in gender, age, past medical history, hospitalization cost, length of stay, blood transfusion rate, blood transfusion volume, emergency DSA rate, emergency operation rate, and mortality between the two groups (P>0.05). Conclusion: Emergency gastroscopy (examination time<12 h) is not a better time for gastroscopy in UGBI patients, does not benefit patients, and may increase the risk.
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    The Research Progress on the Mechanism of Endoplasmic Reticulum Stress in Alzheimer's Disease and the Targeted Therapy for It
    ZHANG Jian-dong, GU Ze-long, YAO Yi-ran, ZHAO Han-fei, WANG Yi, NIU Li-jiao, LI Wei
    2025, 15 (5):  16.  DOI: 10.3969/j.issn.2095-1396.2025.05.003
    Abstract ( 32 )   PDF (1054KB) ( 44 )  
    Endoplasmic reticulum stress (ERS) regulates the expression and activity of beta-site APP-cleaving enzyme 1 (BACE1) at multiple levels including transcription, translation and post-translation by activating the unfolded protein response pathway. This will further alleviate the pathological process of Aβ in Alzheimer's disease. The PERK-eIF2α-ATF4 axis is the key mechanism by which ERS upregulates BACE1. Continuous ERS could prompt PERK to phosphorylate eIF2α, which directly binds to the BACE1 promoter, increasing its transcriptional and protein levels and accelerating amyloid protein production. On the other hand, the IRE1- XBP1s and ATF6 pathways promote the degradation of BACE1 and APP non-amyloidogenic pathway cleavage by upregulating ERAD key factors in early ERS, which has an inhibitory effect on Aβ production. Therefore, the regulation of BACE1 by ERS is bidirectional through the PERK, IRE1 or ATF6 pathways. This article summarized the research progress of the relevant mechanisms, with the aim of seeking new strategies to restore protein homeostasis and slow down the pathological process of AD through intervention targeting ERS.
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