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Mining the Compatibility Rule of Tortoise Shell Based on the Database of Pharmaceutical Intelligence Network HUANG Jian-yi, HUANG Ling, WANG Bo-long 2025, 15 (2):  1.  DOI: 10.3969/j.issn.2095-1396.2025.02.001 Abstract ( 53 )   PDF (2250KB) ( 9 )   Objective: To search Chinese medicine prescriptions containing chinemys reevesii in the database of pharmaceutical intelligence network, and analyze the compatibility of chinemys reevesii to provide reference for its application and development. Methods: Using Microsoft Office Excel 2021, IBM SPSS Modeler 18.0, and IBM SPSS Statistics 23.0, the main therapeutic indications of prescriptions the frequency of use, meridian tropism, and efficacy attribution of Chinese medicines were analyzed, the association rule analysis, cluster analysis, factor analysis and visualization display were also carried out. Results: 139 prescriptions are used to treat 24 kinds of diseases, mainly including liver and kidney yin deficiency syndrome, Chong and Ren disorder disease, mental fatigue disease, and stroke disease. 318 kinds of Chinese medicine in the formula composition, the most commonly used medicine were tonic herbs. The medicine nature is mainly warm, the tastes are mostly sweet, entering liver meridian and kidney meridian. Among the 31 association rules of 22 high-frequency Chinese medicine, the most supported pair medicines combination is“chinemys reevesii-angelica sinensis”, and Triangular medicines combination is“chinemys reevesii-radix rehmanniae preparata-angelica sinensis”, the four medicines combination are“chinemys reevesii-atractylodes macrocephala-radix rehmanniae preparata-angelica sinensis”. 22 high-frequency Chinese medicines can be divided into 4 classes, and 5 factors are extracted. Conclusion: Chinemys reevesii is often combined with tonic herbs with sweet and warm nature, which enters the liver and kidney meridians to treat TCM deficiency diseases such as liver and kidney yin deficiency syndrome, Chong and Ren disorder disease. Related Articles | Metrics

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Research on the Identification and Differentiation Characteristics of Easily Confused Chinese Medicinal Herbs of Saposhnikovia Divaricata and Codonopsis Pilosula HAN Hui-qin, JING Yan-yan, REN Jing, XU Liang-jie, WEI Shu-wen 2025, 15 (2):  8.  DOI: 10.3969/j.issn.2095-1396.2025.02.002 Abstract ( 173 )   PDF (4423KB) ( 101 )   Objective: To study the identification characteristics of Saposhnikoviae Radix and its counterfeit Codonopsis Radix. Methods: Observe the characters and micro-characters of medicinal materials and decoction pieces; Microscopic observation was used to identify the microscopic characteristics of powder and cross section; Qualitative identification was conducted by ultraviolet spectrophotometry and infrared spectrophotometry. Results: There are obvious differences between Saposhnikovia divaricata and Codonopsis pilosula in outer surface color, root position characteristics, section color and smell. The difference between the two sample powders is that Saposhnikovia divaricata contains oil pipes, and the stone cells are rare, oblong or rectangular, and the walls are thick. Codonopsis pilosula contains inulin, connective mammary duct, and stone cells are common, most of which are pointed at one end or one side; The transverse section features that there are many round oil pipes in the phloem of windbreak, and golden yellow secretion can be seen in the pipes; There are many xylem vessels. There are yellowish laticifers scattered in the phloem of Codonopsis pilosula, and few vessels in the xylem. The ultraviolet spectra of Radix Saposhnikoviae and Radix Codonopsis are also obviously different. Conclusion: The method is simple and easy to operate, and its characteristics are obvious and easy to identify,so it can be used to distinguish Saposhnikoviae Radix from Codonopsis Radix. Related Articles | Metrics

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Effect of Doxycycline on Symptom Improvement, LDH and CRP Levels in the Treatment of Severe Mycoplasma Pneumonia in Children DAI Wan-cheng, ZHENG Ai-bin, WANG She-yang 2025, 15 (2):  15.  DOI: 10.3969/j.issn.2095-1396.2025.02.003 Abstract ( 34 )   PDF (1183KB) ( 8 )   Objective: To investigate the effect of doxycycline in the treatment of severe mycoplasma pneumoniae pneumonia (MPP) in children. Methods: From January 2024 to October 2024, 200 children with severe MPP in our hospital were selected and divided into groups according to random number table method. 100 children in the high-dose group were treated with 2 mg·(kg·times)-1 doxycycline twice a day, and the low-dose group was treated with 2 mg·(kg·times)-1 once a day. The maximum single dose of the two groups was less than 100 mg. The therapeutic effect of continuous treatment for 72 h in the two groups was observed, the improvement time of symptoms and the length of hospital stay were compared, and the changes of serum lactate dehydrogenase (LDH) level, C-reactive protein (CRP) level and procalcitonin (PCT) level before and after 72 h of treatment in the two groups were compared, and the occurrence of adverse reactions in the two groups were analyzed. Results: The total effective rate of high dose group was higher than that of low dose group (P<0.05). There was no significant difference in fever resolution time between the two groups (P>0.05), but the time of cough disappearance, rales disappearance and hospital stay in the high-dose group were shorter than those in the lowdose group (P<0.05). Serum LDH, CRP and PCT levels in 2 groups after 72 h treatment were significantly lower than those before treatment, and high dose group was lower than low dose group (P<0.05). The overall incidence of adverse reactions in low dose group was significantly lower than that in high dose group (P<0.05). Conclusion: Doxycycline 2 mg·(kg·times)-1 twice a day is more effective than doxycycline once a day in the treatment of severe MPP in children. High dose of doxycycline is more helpful to early improvement of symptoms and laboratory indicators, but may lead to higher risk of adverse reactions. Related Articles | Metrics

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Observation of the Effect of Different Doses of Pentazocin for Painless Gastroscopy LI Hui, HAN Lei, YUAN Li 2025, 15 (2):  20.  DOI: 10.3969/j.issn.2095-1396.2025.02.004 Abstract ( 33 )   PDF (1156KB) ( 14 )   Objective: To explore the effect of different doses of pentazocine in painless gastroscopy. Methods: A total of 200 patients who underwent painless gastroscopy in the First Affiliated Hospital of Hebei North University from January 2022~January 2023 were selected. All patients were divided into four groups: group A (pentazocin 0.2 mg·kg-1), group B (pentazocine 0.5 mg·kg-1), group C (pentazocine 0.8 mg·kg-1) and group D (control group: sufentanil 0.08 ug·kg-1), with 50 cases in each group. Observation indicators: The behavioural pain scale non-infused (BPS-NI) score was used to compare the analgesic effect of the four groups. The mean arterial pressure (MAP) pressure and heart rate (HR) of the four groups were compared before operation (T0), gastroscopy across the glottis to the upper esophageal end (T1), and at the time of awakening (T2), and the recovery time, recovery ventricular retention time and total amount of propofol were recorded. The occurrence of intraoperative and postoperative adverse reactions was compared. Results: Compared with group D (control group), group A had worse analgesic effect (P<0.05), and the dosage, recovery time and retention time of PACU were higher than those in group D. The dosage of propofol in group C was lower than that in group D, but the recovery time and retention time and incidence of adverse reactions in group C were significantly higher than those in group C (P>0.05). The BPS-NI score and analgesic success rate of group B were similar to those of group D (P>0.05), but the incidence of postoperative adverse reactions was lower than that of group D, and the hemodynamic stability was better than that of group D. Conclusion: Pentazocine at 0.5 mg·kg-1 has the best effect in painless gastrointestinal endoscopy, which is worthy of clinical promotion. Related Articles | Metrics

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A Case Report of Clinical Dyke-Davidoff-Masson Syndrome with Unilateral Limb Hemiparesis and Literature Review WANG Mao, WANG Qiang 2025, 15 (2):  20.  DOI: 10.3969/j.issn.2095-1396.2025.02.005 Abstract ( 20 )   PDF (1382KB) ( 10 )   The Dyke-Davidoff-Masson syndrome is a rare central nervous system disease. In clinical practice, it is necessary to combine complete medical history data and timely use imaging techniques such as cranial CT or MRI for clinical diagnosis of this disease, so as to help patients select better treatment options in a timely manner and reduce the number of misdiagnoses and relapses. In the present study, we undertake a comprehensive analysis of the diagnosis and treatment of one clinical case of Davidoff-Masson syndrome, and referencing pertinent literature to enhance the depth of clinical analysis and furnish a valuable reference for clinical practice. Related Articles | Metrics

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Health Recognition and Linguistic Analysis of Alzheimer's Disease Based on Machine Learning LIU Ning, JIANG Yi-ning, LI Xuan-ang, LI Zhao-feng, SUN Qian 2025, 15 (2):  28.  DOI: 10.3969/j.issn.2095-1396.2025.02.006 Abstract ( 28 )   PDF (1285KB) ( 28 )   Objective: Alzheimer disease (AD) is a neurodegenerative disorder. It usually relies on the working experience of doctors and a better method of using the simple neurological test scale for the diagnosis of AD in the Clinic. Methods: In this study, we use the Coh - Metrix language analysis tool to diagnose AD patients from healthy people by extracting the key features of linguistics, including statements complexity, lexical semantics richness and continuity, etc., finally we use support vector machine (SVM) to do the text classification. Results: It was found that there are significant differences in certain specific linguistic features between the healthy population and AD patients. These features have a certain discriminatory ability for disease recognition. Finally, the accuracy rate of the model is 0.79 which achieves a good result. Conclusion: As a result, the study provides valuable clues and evidence based on the linguistic features to identify AD patients which helps to early diagnosis and intervention of AD based on linguistic features. Related Articles | Metrics

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Based on the “Spleen does not Transport, Body Fluid for Sputum” Prevention and Treatment of Pediatric Epilepsy YANG Bo-jun, XU Li 2025, 15 (2):  34.  DOI: 10.3969/j.issn.2095-1396.2025.02.007 Abstract ( 29 )   PDF (1050KB) ( 7 )   Epilepsy is a manifestation of repeated attacks of consciousness trance, or sudden fainting, mouth mouth, eyes up, limb spasm and other symptoms of the disease. Based on the theory of traditional Chinese medicine, this paper analyzes the interaction between the factors of phlegm dampness, wind evil and blood stasis in the onset of epilepsy. At the same time, emphasize the importance of pregnancy health care, reasonable feeding, outdoor activities to prevent epilepsy. Studies have shown that TCM treatment methods such as regulating the spleen and stomach, removing phlegm, extinguishing wind, tonifying kidney and filling essence have significant advantages in improving the symptoms of children with epilepsy, reducing the seizure frequency and improving cognitive function, providing a new idea for clinical treatment. Related Articles | Metrics

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Research Progress on the Treatment of Atherosclerosis with Natural Medicines ZHAO Meng-sha, ZHANG Xin-hua 2025, 15 (2):  40.  DOI: 10.3969/j.issn.2095-1396.2025.02.008 Abstract ( 44 )   PDF (1075KB) ( 9 )   Atherosclerosis is a chronic, progressive disease caused by damage to blood vessels. Kanglexin (KLX), quercetin, melatonin, tanshinone IIA and other natural drugs play an important role in the process of cell growth, differentiation and proliferation, and have been proven to have an important impact on the regulation of cardiovascular diseases in recent years. In recent years, they have been proven to have an important influence on the regulation of cardiovascular diseases, and it has been discovered that natural products and specific compounds have high value in the treatment of cardiovascular diseases. This article reviews the potential therapeutic potential of these drugs for atherosclerosis by regulating key signaling pathways such as PDGFR-β, JAK2/ STAT3, and PPARδ, as well as by influencing mitochondrial function and antioxidant effects. It provides scientific basis for preventing and treating cardiovascular diseases through natural drugs and offers a new idea for the selection of drugs for treating cardiovascular diseases. Related Articles | Metrics

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Cerebral Ischemia-Reperfusion Injury of New Therapeutic Targets：Mitochondrial Permeability Transition Pore SHANG Rong-zheng, ZHANG Ke-xin, ZHANG Dan-shen 2025, 15 (2):  47.  DOI: 10.3969/j.issn.2095-1396.2025.02.009 Abstract ( 36 )   PDF (1230KB) ( 9 )   Cerebral ischemia-reperfusion injury is a pathological process in which the structure and function of nerve cells are further impaired after the blood supply to ischemic stroke is restored. As the most important and sensitive organelle of the body, mitochondria play a vital role in cell survival, and among the many potential mechanisms of mitochondrial dysfunction, the excessive opening of mitochondrial permeability transition pore is one of the mechanisms that has attracted much attention in recent years. This article systematically reviews the research status of mPTP and I/R, in order to provide new ideas for the clinical treatment of cerebral ischemia and reperfusion injury, which can lead to abnormal opening of mPTP and trigger cell dysfunction. Related Articles | Metrics

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Advances in the Role and Mechanisms of Mitophagy in Alzheimer's Disease MA Meng-fan, ZHAO Zi-yu, ZHANG Xin, SHEN Li-xia 2025, 15 (2):  54.  DOI: 10.3969/j.issn.2095-1396.2025.02.010 Abstract ( 63 )   PDF (1025KB) ( 7 )   The pathogenesis of Alzheimer's disease (AD) has been extensively studied, revealing that impaired mitophagy is one of the critical factors contributing to AD development. In AD, excessive production of reactive oxygen species (ROS) and alterations in mitochondrial membrane potential lead to mitochondrial dysfunction, structural damage, and the accumulation of impaired mitochondria due to defective mitophagy, thereby exacerbating the progression of AD. This review summarizes the relationship between mitophagy and AD, encompassing the hallmarks of AD, the fundamental mechanisms of mitophagy, and the roles of key signaling pathways such as PINK1-Parkin, FUNDC1, and BNIP3/NIX in regulating mitophagy. Additionally, it explores the interactions between mitophagy and pathological hallmarks of AD, including β-amyloid (Aβ) peptides and Tau proteins. By systematically analyzing the interplay between mitophagy and AD, this article aims to provide new insights for early diagnosis and targeted therapy of AD through the enhancement of mitophagy, potentially offering a promising therapeutic strategy for mitigating AD pathology. Related Articles | Metrics

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Research Progress of 8-OHdG and GSH-PX in Vascular Cognitive Impairment Caused by Cerebral Small Vessel Disease WANG Tian-min, XUE Qian, ZHANG Lei, JIANG Song 2025, 15 (2):  61.  DOI: 10.3969/j.issn.2095-1396.2025.02.011 Abstract ( 41 )   PDF (1009KB) ( 26 )   Cerebral small vessel disease (CSVD) is one of the main causes of Vascular cognitive impairment (VCI). In recent years, a large number of studies have shown that oxidative stress plays an important role in the pathogenesis of CSVD. Among them, 8-hydroxydeoxyguanosine (8-OHdG), as a marker of oxidative DNA damage, and Glutathione peroxidase (GSH-PX), as an important antioxidant enzyme in the body, the changes in their levels are closely related to cerebrovascular pathology and cognitive function decline. This article systematically reviews the research progress at home and abroad on 8-OHdG and GSH-PX in CSVD and VCI, summarizes the potential application values of the two in the early diagnosis, disease assessment, and intervention of the diseases, and at the same time discusses the existing deficiencies and future research directions. Related Articles | Metrics