Research Progress of Basal Forebrain Cholinergic Dysfunction in Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2017.04.008

Abstract

Abstract: Excellular senile plaques deposits and intracelllar neurofibrillary tangles are the typical neuropathologies of Alzheimer’s disease （AD）. AD is also characterized by cholinergic hypofunction in hippocampus caused by basal forebrain cholinergic neurons（ BFCNs） dysfunction. This review focues on ACh neurotransmission，BFCNs projective system，the regulatory roles of BFCNs in cognition and the progression of BFCNs dysfunction in AD.

Key words: Alzheimer&, rsquo, s disease, basal forebrain, cholinergic neurons, acetylcholine

CLC Number:

R338，R741.02

TIAN You，WANG Xue，AI Jing. Research Progress of Basal Forebrain Cholinergic Dysfunction in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2017, 7(4): 53-64.

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