Research Progress of Brain-Derived Estrogen in Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2019.05.010

Abstract

Abstract:

Epidemiological studies have shown that the risk of Alzheimer’s disease （AD）in postmenopausal women is much higher than that in men. Numerous clinical trials have indicated that decreased level of brain-derived estrogen in women is related to the risk of AD. This review focuses on the synthesis，metabolism and action mechanisms of estrogen（especially brain-derived estrogen），the role of brain estrogen receptors（ERs），brain-derived estrogen in the regulation of cognitive function and brain-derived estrogen dysfunction in the progression of AD.

Key words: Alzheimer’s disease, brain-derived estrogen, estrogen receptors

CLC Number:

R964

YANG-Lin，AI-Jing. Research Progress of Brain-Derived Estrogen in Alzheimer’s Disease[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.05.010.

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