Research Progress of Curcumin in the Treatment of Nervous System Diseases

doi:10.3969/j.issn.2095-1396.2017.05.008

Abstract

Abstract:

Curcumin is a natural yellow small-molecular plant acid polyphenol extracted from the roots of the genus curcuma turmeric，curcuma，and turmeric. It is the main active ingredient of traditional chinese medicine turmeric. Curcumin has anti-oxidant，antiinflammatory， neuroprotective effects and pharmacological effects such as regulation of neurotransmitters and intracellular signaling pathways. It also enhances neuroplasticity and increases nerve regeneration. These pharmacological effects make curcumin play an important role in neurodegenerative diseases and emotions. It may be used as a drug for the control and treatment of central nervous system diseases such as Alzheimer’s disease，Parkinson’s disease，depression，cerebral ischemia-reperfusion injury in future； curcumin also inhibits tumor cells. Proliferation and clinical use can also be used for the treatment and prevention of glioma. Curcumin has high efficacy and safety，and has little side effects. However，curcumin is difficult to dissolve in water，and low bioavailability limits the development prospect of curcumin in clinical use. It can be compensated by changing the administration mode and dosage form of curcumin. Currently，curcumin can prepare lipids. Dosages such as body，nanoparticle，microspheres，micelles，and microemulsions are administered in different ways to improve their hydrophilicity and improve bioavailability.

Key words: curcumin, nerve center, Alzheimer’s disease, nano-dosage

CLC Number:

R964

Cite this article

REN Jing，ZHANG Dan-shen. Research Progress of Curcumin in the Treatment of Nervous System Diseases[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2017.05.008.

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