Reseach Progress in the Mechanism of Osthole in Protecting Brain Ischemia

Abstract

Abstract: In this paper, the publications of osthole in protecting brain ischemia were retrieved and summarized. Our analysis found that osthole not only can decrease the cerebral ischemia reperfusion injury by inhibiting the inflammation reaction and lowering cerebral edema, but also can increase the activity of antioxidant enzymes in the ischemic tissue of the brain, scavenge oxygen free radicals and reduce ischemia reperfusion injury caused by free radicals. Furthermore, osthole also exhibited a good anticoagulant effect. So the possible mechanisms of the protective role of osthole were reviewed from anti-inflammatory, anti-oxidation, anti- coagulantion, anti-apoptosis and other aspects, in order to provide support for the further pharmacological studies of osthole in brain cerebral ischemia.

Key words: osthole, cerebral ischemia, inflammation, anti-oxidation, anti-coagulantion

CLC Number:

R743

ZHANG Wei, HAN Ning, HU Jinfeng, CHEN Nai-hong. Reseach Progress in the Mechanism of Osthole in Protecting Brain Ischemia[J]. Acta Neuropharmacologica, 2012, 2(2): 42-47.

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