[1] Tu Wen-jun, Qiu Han-cheng, Liu Ya-kun, et al. Elevated levels of adiponectin associated with major adverse cardiovascular and cerebrovascular events and mortality risk in ischemic stroke[J]. Cardiovasc Diabetol, 2020, 19(1):125.

[2] 杜冠华, 张雯, 杜立达, 等.抗脑缺血药物研发现状分析与策略研究[J].神经药理学报, 2018, 8 (1) :1-8.

[3] Rajesh K Mistry, Alison C Brewer. Redox regulation of gasotransmission in the vascular system: A focus on angiogenesis [J]. Free Radic Biol Med, 2017, 108: 500–516.

[4] Cen Juan, Liu Lu, Li Ming-shan, et al. Alteration in P-glycoprotein at the blood-brain Barrier in the early period of MCAO in rats [J]. J Pharm Pharmacol, 2013, 65(5): 665-672.

[5] 岑娟，张峰，姬汴生. 缺血性中风抗氧化治疗的临床问题及研究进展[J]. 中国临床药理学与治疗学, 2013, 18(4): 448-454.

[6] Cen Juan, Zheng Bei-bei, Bai Ru-bing, et al. Triterpenoids from Aglaia abbreviata exert cytotoxicity and multidrug resistant reversal effect in MCF-7/ADM cells via reactive oxygen species induction and P-glycoprotein inhibition[J]. Oncotarget, 2017, 8(41): 69465-69476.

[7] Petr Ježek, Blanka Holendová, Keith D Garlid, et al. Mitochondrial uncoupling proteins: subtle regulators of cellular redox signaling[J]. Antioxid Redox Signal, 2018, 29(7): 667–714.

[8] 岑娟，刘芳芳，张峰. 通过调控反应氧族防治耐药肿瘤的研究进展[J].中国癌症防治杂志, 2017, 9（3）:229-232.

[9] Liu Lu，Huang Wei-wei，Wang Jian-hong，et al. Anthraquinone derivative exerted Hormetic effect on the apoptosis in oxygen-glucose deprivation induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway[J]. Chem-Biol Interact，2017，262：1-11.

[10] Masako Yasuda，Yumi Ohzeki，Shunichi Shimizu，et al. Stimulation of in vitro angiogenesis by hydrogen peroxide and the relation with ETS-1 in endothelial cells[J]. Life Sci, 1999, 64(4)：249–258.

[11] Shyamal C Bir，Shen Xng-gui，Terrance J Kavanagh，et al. Control of angiogenesis dictated by Picomolar superoxide levels[J]. Free Radical Biology and Medicine，2013，63:135-142.

[12] Rajendra S Apte, Daniel S Chen, Napoleone Ferrara. VEGF in signaling and disease: beyond discovery and development[J]. Cell, 2019, 176(6): 1248–1264.

[13] Samuel J Geiseler, Cecilie Morland. The janus face of VEGF in stroke [J]. Int J Mol Sci, 2018,19(5): 1362.

[14] Yang Xi，Zhu Hong-cheng，Ge Yang-yang，et al. Meittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α[J]. Tumor Biology，2014，35(10)：10443-10448.

[15] 夏念，徐丹，侯凯，等. Notch信号通路在脑缺血损伤中的作用机制研究进展[J].药学研究，2018，37(07)：404-407.

[16] Sonia Correia，Paula I Moreira . Hypoxia-inducible factor 1：A new hope to counteract neurodegeneration?[J]. J Neurochem, 2010，112(1):1–12.

[17] Sutton K M, Hayat S, Chau N M, et al. Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1[J]. Oncogene, 2007, 26(27):3920-3929.

[18]  Jin-Sook Kwon， Hosouk Joung， Yong Sook Kim， et al. Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells[J]. Atherosclerosis, 2012，225 (1) ：41-49.

[19] Susan F Fitzpatrick，Murtaza M Tambuwala，Ulrike Bruning，et al. An intact canonical NF-k B pathway is required for inflammatory gene expression in response to hypoxia [J]. J Immunol，2011，186(2)：1091~1096.

[20]  Jennifer L Wilkinson-Berka，Indrajeetsinh Rana，Roksana Armani, et al . Reactive oxygen species，Nox and angiotensin II in angiogenesis：implications for retinopathy [J]. Clin Sci (Lond) 2013 ; 124：597–615.

[21] Yang Ji-ping，Qi Jin-chong，Xiu Bao-xin，et al. Reactive oxygen species play a biphasic role in brain ischemia [J]. J Investigative Surgery，2018, 32(9): 1-6.

[22]  Sho-ichi Yamagishi，Shinjiro Amano，Yosuke Inagaki，et al. Pigment epithelium-derived factor inhibits leptin-induced angiogenesis by suppressing vascular endothelial growth factor gene expression through anti-oxidative properties [J]. Microvasc Res, 2003, 65(3): 186-190.

[23] Julie Nijmeh，Aigul Moldobaeva，Elizabeth M Wagner. Role of ROS in ischemia-induced lung angiogenesis [J]. Am J Physiol Lung Cell Mol Physiol, 2010, 299(4)：L535–L541.

[24] Cen Juan, Zhang Li, Liu Fang-fang, et al. Long-term alteration of reactive oxygen species led to multidrug resistance in MCF-7 cells [J]. Oxid Med Cell Longe, 2016, 2016(1)：7053451.

[25] James R Stone，Tucker Collins. The role of hydrogen peroxide in endothelial proliferative responses [J]. Endothelium, 2002, 9(4): 231–238.

[26] Liu Xiao-liang，Lu Jian，Xing Ji-hong. Stabilization of HIF-1α modulates VEGF and Caspase-3 in the hippocampus of rats following transient global ischemia induced by asphyxial cardiac arrest [J]. Life Sciences, 2016, 151: 243-249.

[27] Eduardo E Benarroch . Hypoxia-induced mediators and neurologic disease[J]. Neurology, 2009, 73(7): 560–565.

[28] Cen Juan, Zhao Na, Huang Wei-wei, et al. Polyamine analogue QMA attenuated ischemic injury in MCAO rats via ERK and Akt activated Nrf2/HO-1 signaling pathway[J]. European J Pharmacology，2019，844：165-174.

[29] Bai Qian，Yang Xian-hui，Lyu Zhi-pai，et al. Epigallocatechin-3-gallate promotes angiogenesis via up-regulation of Nfr2 signaling pathway in a mouse model of ischemic stroke[J]. Behavioural Brain Research，2017，321：79-86.

[30] 谢飞，何延政，刘勇. 活性氧簇对创口愈合过程中血管新生的影响[J]. 华西医学， 2014(10)：1979-1982.

[31] Rit Vatsyayan，Poorna Chandra Rao Lelsani，Pankaj Chaudhary，et al . The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4[J]. Biochem Biophys Res Com, 2012, 417: 346–351.

[32] 孙成成，刘剑刚，刘美霞，等. 慢性脑低灌注致血管性痴呆的病理机制和模型建立[J].神经药理学报，2019，9（1）：13-17.

[33] 白如冰，张忠泉，岑娟，P-糖蛋白在神经元中的表达及氧化应激对P-糖蛋白的影响[J].神经药理学报，2018, 8（3）：9-14.

[34] 任婧, 张丹参. 纳米给药系统脑靶向配体的研究进展[J].神经药理学报, 2017, 7 (4) :17-25.