Acta Neuropharmacologica ›› 2018, Vol. 8 ›› Issue (1): 1-8.DOI: 10.3969/j.issn.2095-1396.2018.01.001

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New Strategies for the Drug Development of Anti-cerebral Ischemia
—Advances in the Etiology and Drug Development of Acute Cerebral Ischemia

DU Guan-hua,ZHANG Wen,DU Li-da,MA Yin-zhong,LI Li,WANG Yue-hua   

  1. 1.  Beijing Key Laboratory of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100050,China
    2.  School of Biomedical Science,The Chinese University of Hong Kong,Hong Kong,China
  • Online:2018-02-26 Published:2018-06-04
  • Contact: 杜冠华,男,博士生导师;研究方向:神经药理与新药发现;Tel:+86-010-63165184,E-mail:dugh@imm.ac.cn
  • Supported by:

    中国医学科学院协同创新工程(No.2017-I2M-1-010),国家自然科学基金项目(No.81603100)

Abstract: Acute cerebral ischemia (stroke) is a major disease which threat to people’s health because of its high incidence,high mortality and high morbidity. Of particular concern is that the clinical application of a serious lack of prevention and treatment of drugs,and a large number of research and development of drugs has not been successful. This paper analyzes the current status of prevention and treatment of acute cerebral ischemia drugs and the reasons for its lack of success. It is proposed that a new strategy is necessary for new drug development and research. Based on the recognization of the analysis of the disease pathology and drug research,we suggested the disease pathogenesis and features based strategy and pathological process based drug development strategies.

Key words: acute cerebral ischemia, prevention and treatment of drugs for stroke, drugresearch and development strategy

CLC Number: