Research Progress of the Role and Underlying Mechanism of Dynorphin/κ Opioid Receptor in the Development of Depression

doi:10.3969/j.issn.2095-1396.2018.01.007

Abstract

Abstract: Depression is a serious mental disorder charactered by high prevalence，major depression always result in great harm to society. At present，the most popular antidepressants including monoamine reuptake inhibitors have some deficits including slower effect，side-effect. At the same time，some patients do not response adequately to the antidepressant medication. The development of drugs targeting opioid receptor has shown promising prospect，clinical studies have demonstrated that κ opioid receptor antagonist Buprenorphine could possibly cure depressive symptoms in patients with classical antidepressants treatment-resistant depression. In present review，we discuss the recent progress of the role of κ opioid receptor in different brain regions during the development of depression，and introduce the association between dynorphin/κ opioid receptor and CRF as well as monoamine system. Furthermore，we briefly introduce the upstream and downstream molecules of κ opioid receptor that contribute to the development of depression.

Key words: &, kappa, opioid receptor, depression, monoamine, corticotrophin releasing factor（CRF）, p38

CLC Number:

R964

ZAN Gui-ying，SUN Xiang，LI Qing-lin，LIU Jing-gen. Research Progress of the Role and Underlying Mechanism of Dynorphin/κ Opioid Receptor in the Development of Depression[J]. Acta Neuropharmacologica, 2018, 8(1): 54-64.

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