Progress on the Relationship between Pathogenic Microorganisms and Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2020.04.010

Abstract

Abstract:

Alzheimer’s disease（ AD），a cerebral disease，accounts for the majority of senile dementia that affects the health of the old. Although many theories on AD pathogenesis have been proposed，so far，there are no effective treatments to restrict its development. Recently “infection hypothesis” of AD have shown that a variety of pathogenic microorganism can directly penetrate

the blood-brain barrier （BBB），reach the brain，cause inflammatory reactions，and damage neurons. The most common pathogens through BBB are herpes simplex virus，Cytomegalovirus，Chlamydia pneumoniae，Spirochetes，Helicobacter pylori，Porphyromonas gingivalis，Fungus. In this article，we mainly discussed the potential role of pathogenic microorganisms in the etiologyand progression of AD，expounded the relationship between pathogens and AD，which would provide theoretical basis for the pathogenesis，prevention and treatment of AD.

Key words: Alzheimer’s disease, bacteria, virus, fungi, inflammation, infection

CLC Number:

R965

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HAI Ji-tao, LUO Huan-min. Progress on the Relationship between Pathogenic Microorganisms and Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2020, 10(4): 58-64.

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URL: http://actanp.hebeinu.edu.cn/EN/10.3969/j.issn.2095-1396.2020.04.010

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References

[1] Alzheimer's Association. 2015 Alzheimer's disease facts and figures[R]. Alzhmer's & Dementia, 2015, 11(3): 332-384.

[2] Rebecca Nisbet, Juan Carlos Polanco, Lars Matthias Ittner, et al. Tau aggregation and its interplay with amyloid-β[J]. Acta Neuropathol, 2015, 129(2): 207-220.

[3] Terry R D, Masliah E, Salmon D P, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment[J]. Annals of Neurology, 1991, 30(4): 572-580.

[4] Li Chuan-yu, Zhao Rui, Gao Kai, et al. Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease[J]. Current Alzheimer Research, 2011, 8(1): 67-80.

[5] Zsuzsanna Nagy. The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease[J]. J Cellular and Molecular Medicine, 2005, 9(3): 531-541.

[6] Kenneth Beagley, Wilhelmina M Huston, Philip Hansbro, et al. Chlamydial infection of immune cells: altered function and implications for disease[J]. Critical Reviews in Immunology, 2009, 29(4): 275-305.

[7] Charles W Stratton, Subramaniam Sriram. Association of Chlamydia pneumoniae with central nervous system disease[J]. Microbes and Infection, 2003, 5(13): 1249-1253.

[8] Katerina Wolf, Elizabeth Fischer, Ted Hackstadt. Ultrastructural analysis of developmental events in Chlamydia pneumoniae-infected cells[J]. Infection and Immunity, 2000, 68(4): 2379-2385.

[9] Brian J Balin, Herve C Gérard, E James Arking, et al. Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain[J]. Medical Microbiology and Immunology, 1998, 187(1): 23-42.

[10] Herve C Gérard, Ute Dreses-Werringloer, Kristin S Wildt, et al. Chlamydophila (Chlamydia) pneumoniae in the Alzheimer's brain[J]. FEMS immunology and medical microbiology, 2006, 48(3): 355-366.

[11] Christine J Hammond, Loretta R Hallock, Raymond J Howanski, et al. Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain[J]. BMC Neuroscience, 2010, 11(1): 121.

[12] Itzhaki R F, Wozniak M A, Appelt D M, et al. Infiltration of the brain by pathogens causes Alzheimer's disease[J]. Neurobiology of Aging, 2004, 25(5): 619-627.

[13] Judith Miklossy. Historic evidence to support a causal relationship between spirochetal infections and Alzheimer's disease[J]. Frontiers in Aging Neuroscience, 2015, 7: 46.

[14] Garth Nicolson. Chronic bacterial and viral infections in neurodegenerative and neurobehavioral diseases[J]. Laboratory Medicine, 2008, 39(5): 291-299.

[15] Ingar Olsen, Sim Singhrao. Can oral infection be a risk factor for Alzheimer's disease?[J]. J Oral Microbiology, 2015, 7(1): 29143.

[16] Judith Miklossy, Sandor Kasas, Robert C Janzer, et al. Further ultrastructural evidence that spirochaetes may play a role in the aetiology of Alzheimer's disease[J]. Neuroreport, 1994, 5(10): 1201-1204.

[17] Judith Miklossy. Bacterial amyloid and DNA are important constituents of senile plaques: further evidence of the spirochetal and biofilm nature of senile plaques[J]. J Alzheimer's Disease: JAD, 2016, 53(4): 1459-1473.

[18] Judith Miklossy, Kamel Khalili, Lise Gern, et al. Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease[J]. Journal of Alzheimer's disease: JAD, 2004, 6(6): 639-649.

[19] Miklossy J, Kis A, Radenovic A, et al. Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes[J]. Neurobiology of Aging, 2006, 27(2): 228-236.

[20] Riviere G R, Riviere K H, Smith K S. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease[J]. Oral Microbiology and Immunology, 2002, 17(2): 113-118.

[21] Judith Miklossy. Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria[J]. Journal of Neuroinflammation, 2011, 8(1): 90.

[22] BarryJ Marshall, J Robin Warren. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration[J]. Lancet (London, England), 1984, 1(8390): 1311-1315.

[23] Dulciene M M Queiroz, Andreia M C Rocha, Jean E Crabtree. Unintended consequences of Helicobacter pylori infection in children in developing countries: iron deficiency, diarrhea, and growth retardation[J]. Gut Microbes, 2013, 4(6): 494-504.

[24] Claire Roubaud Baudron, Christine Varon, Francis Mégraud, et al. Alzheimer's disease and Helicobacter pylori infection:a possible link?][J]. Geriatrie et Psychologie Neuropsychiatrie du Vieillissement, 2016, 14(1): 86-94.

[25] May A Beydoun, Hind A Beydoun, Martine Elbejjani, et al. Helicobacter pylori seropositivity and its association with incident all-cause and Alzheimer's disease dementia in large national surveys[J]. Alzheimer's & Dementia : J Alzheimer's Association, 2018, 14(9): 1148-1158.

[26] Jannis Kountouras, Marina Boziki, Emmanuel Gavalas E, et al. Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer's disease[J]. J Neurology, 2009, 256(5): 758-767.

[27] Chang Yang-pei, Chiu Guei-Fen, Kuo Fu-Chen, et al. Eradication of helicobacter pylori is associated with the progression of dementia: A population-based study[J]. Gastroenterology Research and Practice, 2013, (16): 175729.

[28] Seiji Shiota, Kazunari Murakami, Aoi Yoshiiwa, et al. The relationship between Helicobacter pylori infection and Alzheimer's disease in Japan[J]. J Neurology, 2011, 258(8): 1460-1463.

[29] Guo Yong-hua, Ky-Anh Nguyen, Jan Potempa. Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins[J]. Periodontology, 2000, 2010, 54(1): 15-44.

[30] Sim Singhrao, Alice Harding, Sophie Poole, et al. Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer's disease[J]. Mediators of Inflammation, 2015, (4): 137357.

[31] Stephen S Dominy, Casey Lynch, Florian Ermini, et al. Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors[J]. Science Advances, 2019, 5(1): eaau3333.

[32] Vladimir Ilievski, Paulina K Zuchowska, Stefan J Green, et al. Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice[J]. PloS One, 2018, 13(10): e0204941.

[33] Ding Ye, Ren Jing-yi, Yu Hong-qiang, et al. Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice[J]. Immunity & Ageing : I & A, 2018, 15(1): 6.

[34] Nie Ran, Wu Zhou, Ni Jun-jun, et al. Porphyromonas gingivalis infection induces amyloid-β accumulation in monocytes/macrophages[J]. J Alzheimer's Disease: JAD, 2019, 72(2): 479-494.

[35] Diana Pisa, Ruth Alonso, Alberto Rábano, et al. Different brain regions are infected with fungi in Alzheimer's disease[J]. Scientific Reports, 2015, 5: 15015.

[36] Ruth Alonso, Diana Pisa, Alberto Rábano, et al. Alzheimer's disease and disseminated mycoses[J]. European J Clinical Microbiology & Infectious Diseases: Official Publication of the European Society of Clinical Microbiology, 2014, 33(7): 1125-1132.

[37] Ruth Alonso, Diana Pisa, Anabel Marina, et al. Fungal infection in patients with Alzheimer's disease[J]. J Alzheimer's Disease: JAD, 2014, 41(1): 301-311.

[38] Ruth Alonso, Diana Pisa, Ana M Fernández-Fernández, et al. Infection of fungi and bacteria in brain tissue from elderly persons and patients with Alzheimer's disease[J]. Frontiers in Aging Neuroscience, 2018, 10: 159.

[39] Diana Pisa, Ruth Alonso, Alberto Rábano A, et al. Fungal Enolase, β-Tubulin, and chitin are detected in brain tissue from Alzheimer's disease patients[J]. Frontiers in Microbiology, 2016, 7(179): 1772.

[40] Ann-Marie Lobo, Alex Agelidis, Deepak Shukla. Pathogenesis of herpes simplex keratitis: The host cell response and ocular surface sequelae to infection and inflammation[J]. The Ocular Surface, 2019, 17(1): 40-49.

[41] Steven A Harris, Elizabeth Harris. Herpes simplex virus type 1 and other pathogens are key causative factors in sporadic Alzheimer's disease[J]. J Alzheimer's Disease: JAD, 2015, 48(2): 319-353.

[42] Federico Licastro, IIaria Carbone, Elena Raschi, et al. The 21st century epidemic: infections as inductors of neuro-degeneration associated with Alzheimer's Disease[J]. Immunity & Ageing: I & A, 2014, 11(1): 22.

[43] 孙奕, 周辰, 潘晓东, 等. 1型单纯疱疹病毒抗体与阿尔茨海默病的关联研究[J]. 徐州医科大学学报, 2017, 37(6): 372-376.

[44] Ruth F Itzhaki, Richard Lathe, Brian J Balin, et al. Microbes and Alzheimer's disease[J]. J Alzheimer's Disease: JAD, 2016, 51(4): 979-984.

[45] Ruth F Itzhaki. Corroboration of a major role for herpes simplex virus type 1 in Alzheimer's disease[J]. Frontiers in Aging Neuroscience, 2018, 10: 324.

[46] Hugo Lovheim, Jonathan Gilthorpe, Rolf Adolfsson, et al. Reactivated herpes simplex infection increases the risk of Alzheimer's disease[J]. Alzheimer's & Dementia: J Alzheimer's Association, 2015, 11(6): 593-599.

[47] Nell S Lurain, Barbara Hanson, Jeffrey Martinson, et al. Virological and immunological characteristics of human cytomegalovirus infection associated with Alzheimer disease[J]. The J Infectious Diseases, 2013, 208(4): 564-572.

[48] Stefania Varani, Maria Paola Landini. Cytomegalovirus-induced immunopathology and its clinical consequences[J]. Herpesviridae, 2011, 2(1): 6.

[49] Ilaria Carbone, Tiziana Lazzarotto, Manuela Ianni, et al. Herpes virus in Alzheimer's disease: relation to progression of the disease[J]. Neurobiology of Aging, 2014, 35(1): 122-129.

[50] Lisa Barnes, Ana W Capuano, Alison E Aiello, et al. Cytomegalovirus infection and risk of Alzheimer disease in older black and white individuals[J]. The J Infectious Diseases, 2015, 211(2): 230-237.

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