ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (1): 40-46.DOI: 10.3969/j.issn.2095-1396.2020.01.009

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Study Progress on Phytoestrogen-Mediated Mitochondrial Pathway’s Neuroprotective Effects in Alzheimer’s Disease

ZHEN Yan-jie,GUO Tong-lin,ZHAO Yu-wei,SHEN Li-xia   

  1. Department of Pharmacy,Hebei North University,Zhangjiakou,075000,China
  • Online:2020-02-26 Published:2020-02-26
  • Contact: 沈丽霞,女,博士,教授,硕士生导师;研究方向:神经药理学;Tel:+86-0313-4029305,E-mail:shenlixiacn@163.com
  • About author:甄艳杰,女,硕士研究生;研究方向:神经药理学;E-mail:Zhenyj@163.com
  • Supported by:
    河北省自然科学基金资助项目(No.H2019405057),河北省高等学校科学技术研究项目(No.ZD2020136)

Abstract:

Alzheimer’s disease (AD) is a neurodegenerative disease that is more common in the elderly,mainly manifesting as memory loss,cognitive dysfunction,and behavioral abnormalities. Studies have found that estrogen (ER) replacement therapy can delay the progression of AD,but its application can cause various side effects,so finding new treatments has become an inevitable trend. Studies have shown phytoestrogen (PE),which has a similar structure to 17β-estradiol,has a good effects on AD and has fewer side effects,and can replace estrogen to play a neuroprotective role in treating AD. It is well known that mitochondria are an important factor for cell survival in all cell morphologies. The normal functioning of neurons depends to a large extent on the health of mitochondria. This text will review the related content of the phytoestrogens-mediated mitochondrial protective effect on neurons.

Key words: Alzheimer’s disease, phytoestrogens, mitochondria, neuroprotective effects