ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (6): 54-59.DOI: 10.3969/j.issn.2095-1396.2020.06.010

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Research Progress of High-Fat Diet and Alzheimer’s Disease

HUANG Ying,HUO Yan-li,MING Yue,HAO Jun-rong   

  1. 1 Department of Pharmacy, Hebei North University, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China  2 Basic Medical College, Hebei North University, Zhangjiakou, 075000, China
  • Online:2020-12-26 Published:2020-12-26
  • Contact: 郝军荣,女,讲师;研究方向:神经药理学及相关药物;Tel:+86-0313-4029306,E-mail:haojunrong3@163.com
  • About author:黄颖,女,河北北方学院 16 级本科生;研究方向:神经药理学;E-mail:554048967@qq.com
  • Supported by:

    河北省自然科学基金项目(No.H2019405057);河北省高等学校科学技术研究项目(No.ZD2020136)

Abstract:

High-fat diet plays an important role in the pathogenesis of AD. This paper reviews the possible pathogenesis of Alzheimer’s disease in recent yearsand further expounds the possible mechanism of high fat diet causing Alzheimer’s disease:High fat diet increases the content of saturated free fatty acids in plasma and speeds up the pathological process of AD; High fat diet promotes the occurrence of AD by influencing blood lipid levels;A high-fat diet will lead to the production of large amounts of fat and cause chronic inflammationthe inflammatory factors produced cross the blood-brain barrier and stimulate neuroinflammatory cells;High-fat food will affect the gut bacteriawhich in turn affect the microbiota - brain - gut axisthen lead to the AD. Based on the above mechanismswe can treat or prevent AD by reducing free saturated fatty acidsregulating lipid metabolism disordersimproving inflammationand regulating intestinal flora.

Key words: high-fat diet, Alzheimer’s disease, free saturated fatty acids, blood lipid, inflammatory factors, intestinal flora

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