ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (6): 48-53.DOI: 10.3969/j.issn.2095-1396.2020.06.009

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Relationship between Adult Hippocampus Neurogenesis and Alzheimer’s Disease

DING Sheng-kai,LIU Qing-qing,LIU Xin-yang,SHANG Ya-zhen   

  1. Institute of Traditional Chinese Medicine,Chengde Medical University;Key Research Laboratory of Antidementia of Traditional Chinese Medicine,Hebei Province;Key Laboratory of Traditional Chinese Medicine Research and Development of Hebei Province,Chengde,067000,China
  • Online:2020-12-26 Published:2020-12-26
  • Contact: 商亚珍,女,博士,博士生导师,教授;研究方向:中药抗痴呆;Tel:+86-0313-2290616,E-mail:973358769@qq.com
  • Supported by:

    河北省自然基金资助项目(No. C2009001007H2014406048H2019406063);河北省中医药管理局资助项目(No. 050272014062); 河北省教育厅重点项目(ZD20131022ZD2019057);首届河北省百名优秀创新人才支持计划项目;河北省中药学重点学科建 设项目;承德医学院中药药理学重点发展学科资助项目;承德医学院科技创新团队项目

Abstract:

Alzheimer’s disease(AD)is a common neurodegenerative disease in old age and has been published by world health organization(WHO)as one of the largest global public health issues facing mankind. The main clinical symptom is the progressive decline of learning and memory ability. The neuropathological changes of AD include senile plaque(SP)formed by β-amyloid protein(Aβ)of accumulated outside of neuonneurofibrillary tangle(NFT) formed by hyperphosphorylated Tau protein of inside the neuronneuron loss and degenerationsynapse decrease and so on. Especiallythe abnormal neurogenesis is also involved in the neuropathological process of AD. There are many studies have showed that neurogenesis is a process of neural stem cells in hippocampal dentate gyrus of adult mammals to produce new neuron. The increased adult neurogenesis can compensate the injured neurons and save the learning and memory impairment. Thenthe promotion of adult hippocampal neurogenesis may  be beneficial to treatment of AD. The present paper summarizes the relationship between the adult hippocampal neurogenesis and Alzheimer’s disease.

Key words: neurogenesis, Alzheimer’s disease, review

CLC Number: