ACTA NEUROPHARMACOLOGICA ›› 2020, Vol. 10 ›› Issue (4): 51-57.DOI: 10.3969/j.issn.2095-1396.2020.04.009

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Exosomes Derived from Retinal Pigment Epithelial Cells and Age-Related Macular Degeneration

ZHANG Si-qi,ZHANG Yuan-yuan   

  1. Hebei North University,Zhangjiakou,075000,China
  • Online:2020-08-26 Published:2020-08-26
  • About author:张元元,讲师,博士;研究方向:眼科疾病及抗肿瘤药物筛选;E-mail:yuanyuanzhangyyz@163.com
  • Supported by:
    河北北方学院博士启动基金( No.BSJJ201905),河北北方学院大学生创新创业训练计划项目(No.1007)

Abstract:

Age-related macular degeneration (AMD) is also known as age-related macular degeneration and age-related macular degeneration.Multiple eyes are onset. When the disease occurs,the eyes generally occur one after another or at the same time. There are visual impairments such as central dark spots and visual distortion. Most of them occur in middle-aged and elderly people over 50 years old. An important cause of blindness in middle-aged and elderly people today.In the field of ophthalmology,it is generally believed that exosomes secreted by retinal pigment epithelium( RPE) cells are likely to participate in the occurrence and development of AMD. RPE cells secrete exosomes that carry their contents,transfer them to nearby or distant cells,complete the exchange of information between cells,and cause a certain degree of influence on the cells. Inflammation and other pathophysiological processes play an important role.While conducting in-depth research on RPE cell exosomes,it also discovered the new potential of exosomes for early diagnosis and treatment of AMD,bringing new directions for AMD research.

Key words: retinal degenerative diseases, age-related macular degeneration, retinal pigment epithelial cells, exosomes

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