Neural Stem Cells with It’s Pharmacology

Abstract

Abstract: Neural stem cells (NSCs) are highly capable of self-renewal, they are the precursor cells for differentiation into neurons and gliocyte. Researches on the mechanisms of NSCs proliferation and differentiation are of great significant for the treatment of degenerative diseases of the nervous system and functional restoration. Research has shown that NSCs have therapeutic effects that include stem cell homing, planting and activation of endogenous NSCs, more importantly, neural stem cells also have the pharmacological effect with neurocyte growth regulatory factors (NGRFs) secretion. In-depth study of these NGRFs will not only has great importance for the nerve cells’ regeneration and functional reconstruction, but also provides guiding significance for the pharmacological mechanism of macromolecular in new drug development.

Key words: neural stem cells (NSCs), neurocyte growth regulatory factors (NGRFs), traditional chinese medicine, clinical application

CLC Number:

R964

LI Xin, HUO Yu-shu. Neural Stem Cells with It’s Pharmacology[J]. Acta Neuropharmacologica, 2012, 2(2): 48-57.

References

[1] 苏肖英, 汪海涛, 孟茜, 等. 不同生长因子对神经干细胞定向分化的影响[J].广东医学, 2011, 32(9):1089-1091.

[2] 孟红旗, 全亚萍. 神经干细胞在神经系统疾病中的应用[J].中国组织工程研究与临床, 2010, 14(1):175-178.

[3] Brent A Reynolds, Samuel Weiss. Generation of neurons and astrocytes from isolated cells of the adultnammalian centralnervous system [J]. Science, 1992, 255(5052): 1707-1710.

[4] Gage H F. Mammalian neural stem cells [J]. Science, 2000, 287(5457): 1433-1438.

[5] Syed Ameer Basha Paspala, Awari Bhaskara Balaji, Parveen Nyamath, et al. Neural stem cells & supporting cells- the new therapeutic tools for the treatment of spinal cord injury[J]. Indian J Med Res, 2009, 130(4): 379-391.

[6] Philip H Schwartz, Peter J Bryant, Tannin J Fuja, et al. Isolation and characterization of neural progenitor cells from post-mortemhumancortex [J].Neurosci Res, 2003, 74(6): 838-851.

[7] David M Panchision, Chen Hui-Ling, Francesca Pistollato, et al. Optimized flowcytometric analysis of central nervous system tissue reveals novel functional relationships among cells expressing CD133, CD15, and CD24[J]. Stem Cells, 2007, 25(6): 1560-1570.

[8] 谢姜. 人脐带间充质干细胞诱导转化成神经干细胞及其移植治疗脑出血的研究[D]. 北京. 中国医学科学院, 2010.

[9] Dale Woodbury, Emily J Schwarz, Darwin J Prockop. Adult rat and human bone marrow stromal cells differentiate into neurons [J].J Neurosci, 2000, 61(4): 364-367.

[10] S Ausim Azizi, David Stokes, Brian J Augelli. Engraftment and migration of human bone marrow stromal cells implantedin the brains of albino rats-similarities to astrocyte grafts [J].Proc Natl Acad Sci USA, 1998, 95(7):3908-3913.

[11] Sanchez-Ramos J, Song S, Cardozo-Pelaez F. Adult bone marrow stromal cells differentiate in to neural cells in vitro [J]. Exp Neurol, 2000, 164(2): 247-256.

[12] Gene C Kopen, Darwin J Prockop, Donald G Phinney. Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains [J]. Proc Natl Acad Sci USA, 1999, 96(19): 107.

[13] Nathan J Zvaifler, Lilla Marinova-Mutafchieva, Gill Adams, et al. Adams G Mesenchymal precursor cells in the blood of normal individuals [J].Arthritis Res, 2000, 2(6):477-488.

[14] 屈红林, 彭瑞. 神经干细胞研究现状及在运动医学领域中的应用[J]. 中国组织工程研究与临床修复, 2008, 12(25): 4941-4944.

[15] 胡继良, 姜晓丹, 邹雨汐, 等. 成年小鼠脑室下区神经干细胞培养与鉴定体系的建立[J]. 南方医科大学学报, 2008, 28(11): 1942-1946.

[16] 褚尤彪, 罗卓荆, 曹延林, 等. 脊髓神经干细胞培养及体外诱导分化实验研究[J]. 中华神经外科疾病研究杂志, 2006, 5(1): 19-22.

[17] 彭绍华, 戴冀斌, 田毅浩. 小鼠胚胎大脑皮质与中脑神经干细胞培养与分化比较的研究[J]. 解剖学报, 2005, 36(6): 660-664.

[18] 闫长祥, 安沂华, 历俊华, 等. 大鼠脊髓源性神经干细胞的培养分化及其特异性研究[J]. 中华神经外科杂志, 2003, 19(2): 135-137.

[19] Deng Xing-Li, Liu Ruen, Feng Zhong-Tang, et al. In vitro culture and differentiation of rat embryonic midbrain-derived neural stem cells[J]. Neural Regen Res, 2008, 3(11): 1241-1244.

[20] 陈梅玲, 沈岳飞, 刘开祥, 等. 大鼠神经干细胞体外培养的研究[J].广东医学, 2011, 32(1): 34-37.

[21] Milosevic J, Storch A, Schwarz J. Spontaneous apoptosis in murine free-floating neurospheres[J]. Exp Cell Res, 2004, 294(1): 9-17.

[22] 王飞, 黄强, 李世亭, 等．全反式维甲酸诱导神经干细胞分化实验研究[J]．中华神经外科疾病研究杂志, 2005, 4(2):145-148.

[23] 赵峰, 马晶, 余鸿. 影响神经干细胞增殖、分化的外部因素[J].四川解剖学杂志, 2008, 16(4): 36-38.

[24] 杨娟, 陈付学, 梁光义. 刺梨多糖对神经干细胞谷氨酸损伤的保护作用[J]. 营养学报, 2005, 27(4): 339-341.

[25] 高唱, 王景周. 左归丸对体外培养新生大鼠海马神经干细胞增殖分化的影响[J].中国医药学报, 2004, 19(11):691-693.

[26] 乌优图, 王运杰. 神经生长因子对神经干细胞分化及神经元轴突形成的影响[J].中国组织工程研究与临床康复, 2008, 12(29):5631-5635.

[27] 黎海燕, 罗杰峰, 沈岳飞. 控制和影响神经干细胞增殖分化为神经元细胞的途径及因素[J].中国组织工程研究与临床康复, 2007, 11(3):559-562.

[28] 姜振. 神经营养因子与神经干细胞的增殖与分化:基于汤森路透Web of Science 数据库文献检索[J].中国组织工程研究, 2012, 16(14):2597-2606.

[29] Hong J Lee, In J Lim, Seung W Park et al. Human neural stem cells genetically modified to express human nerve growth factor(NGF) gene restore cognition in mouse with ibotenic acid-induced cognitive dysfunction[J].Cell Transplant, 2012, 20(6): 2487-2496.

[30] Sonia Martinez-herrero, Ignacio M.Larrayoz, Laura Ochoa-Callejero, et al. Adrenomedullinas a growth and cell fate regulatory factor for adult neural stem cells[J]. Stem Cells, 2012, 08(1):1-18.

[31] Nga Nguyen, Sang Bae Lee, Yung Song Lee. et al. Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathwa[J]. Neurochemical Research, 2009, 34(5):942-951.

[32] Subbiah Pugazhenthi, Sreekala Nair, Kalpana Velmurugan, et al. Varicella-zoster virus infection of differentiated human neural stem cells[J]. J Virology, 2011, 85(13): 6678-6686.

[33] H S Dua, A Joseph, V A Shanmuganathan. Stem cell diferentiation and the efects of deficiency[J].Eye(Lond), 2003, 17(8): 877-885.

[34] Lachapelle Fibroblast, Avellana-Adalid Virginia, Nait-Oumesmar Brahim, et al. Fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor AB(PDGFAB) promote adult SVZ-derived oligodendrogens is in vivo[J]. Mol Cell Neurosci, 2002, 20(3): 390-403.

[35] Agnes Lukaszewicz, Pierre Savatier, Veronique Cortay, et al. Contras ting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cell[J].J Neurosci, 2002, 22(15): 6610-6622.

[36] Peter Moosmann, Oleg Georgiev, Hans-Jurgen Thiesen, et al. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor[J]. Biol Chem, 1997, 378(7): 669–677.

[37] Chen Xiao-Dong, Robert L-Jika. Maintenance and propagation of mesenchymal stem cells[P]. US Serial No. 11/625,763.

[38] Chen Xiao-Dong. Extracellular matrix provides optimal niche for maitenance and propagation of mesenchymal stem cells[J]. Birth Defects Res C Embryo Today, 2010, 90(1): 45-54.

[39] Kyung-Chul Choi, Do-Sung Yoo, Kyung-Sock Cho, et al. Effect of single growth factor and growth factor combinations on differentiation of neural stem cells[J].Korean Neurosurg Soc, 2008, 44(6):375-381.

[40] Yevgeniya I Tarasenko, Yu Yong-jia, Paivi M Jordan, et al. Effect of growth factors on proliferation and phenotypic differentiation of human fetal neuraI stem cells[J]. Neurosc Res, 2004, 78(5):625-636.

[41] Curt R Freed, Paul E Greene, Robert E Breeze, et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease [J]. N Engl J Med, 2001, 344(10): 710-719.

[42] P M Carvey, Z D Ling, C E Sortwell, et al. A clonal line of mesencephalic progenitor cells converted to dopamine neurons by hematopoietic cytokines: a source of cells for transplantation in Parkinson's disease[J]. ExpNeurol, 2001, 171(1):98-108.

[43] Maria H Nilsson, Albert Westergren, Carlsson Gunilla, et al. Uncovering indicators of the international classification of functioning, disability, and health from the 39-item Parkinson's disease questionnaire[J]. Parkinsons Dis, 2010, 2010:984673.

[44] 栾佐, 屈素清, 刘卫鹏, 等. 人神经干细胞移植治疗重度视觉障碍脑瘫患儿的临床观察[J].中国康复理论与实践, 2007, 13(12): 1103-1105．

[45] 郭国庆, 沈伟哉, 钟世镇. 丹参素和丹酚酸对胎鼠脑神经干细胞迁移的诱导[J].中国组织工程研究与临床康复, 2007, 11(7):1225-1228.

[46] 刘柏炎, 蔡光先. 补阳还五汤对低糖低氧损伤神经干细胞移行分化的影响[J].中国药物与临床, 2005, 5(3):171-173.

[47] 刘喆, 赖新生. 电针对局灶性脑缺血成年大鼠内源性神经干细胞增殖的影响[J].中国康复医学杂志, 2007, 22(1):218-221.

[48] Deng Xing-Li, Liu Ru-En, Feng Zhong-Tang, et al．Establishment of midbrain-derived neural stem cells modified by BDNF and EGFP gene[J]. Chin J Clin Neurosurg, 2008, 13(3): 161-167．

[49] Gao Jun-Ling, Donald S Prough, David J McAdoo, et al．Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury [J].Experimental Neurology, 206, 20l(2): 281-292.

[50] 王磊, 王连仲. 神经干细胞与脊髓损伤的治疗[J].中国组织工程研究与临床修复, 2008, 12(12): 2335-2338.

[51].于海波, 马晓明, 饶晓丹, 等. 艾灸任脉经穴对脑缺血再灌注大鼠组织超微结构及巢蛋白表达的影响[J].中华中医药学刊, 2010, 4(4):715-717.

[52] Asamoto S, Sugiyama H, Doii H, et al. Hyperbaric oxygen(HBO) therapy for acute traumatic cervical spinal cord injury[J].Spinal Cord, 2000, 38(9):538-540.

[53] Critante A F, Damasceno M L, Barros Filbo T E, et al. Evaluation of the effects of hyperbaric oxygen therapy for spinal cord lesion in correlation with the moment of intervention[J].Spinal Cord, 2012, 50(7):502-506.

[54] 刘海, 王忠诚, 安沂华, 等．高压氧对大鼠脊髓损伤后内源性神经干细胞的诱导作用[J]. 中国康复理论与实践, 2006, 15(5): 369-371.

[55] 崔荣太, 蒲传强, 刘洁晓. 人参皂苷Rg1对大鼠局灶性脑缺血脑组织神经干细胞增殖的影响[J].中华老年心脑血管并杂志, 2007, 9(10): 707-709.

[56] 张烽, 顾玉东, 徐建光, 等. 银杏叶提取物促进大鼠坐骨神经再生的实验研究[J]. 中华显微外科杂志, 2000, 23(4): 279-281．

[57] 林浩东, 王欢, 陈德松, 等．银杏酮酯对周围神经再生的影响[J]. 中华实验外科杂志, 2006, 23(7):879.

[58] Hsu Shan-Hui, Chang Chen-Jung, Tang Cheng-Ming, et al．In Vitro and in vivo effects of Ginkgo bilobaextract Egb 761 on seeded Schwann ceels within poly(DL-lactic acid-co-g1yco1ic acid) conduits for peripheral nerve regeneration[J]. Biomater Appl, 2004, 19:163-182．

[59] 缪兵, 高建新, 刘星霞, 等. 银杏内酯B 对神经细胞活性影响的实验研究[J]. 山东医药, 2004, 44(20):16-18.

[60] Li Hua, Deng Chang-Qing, Chen Bei-Yang, et al. Total saponins of panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia -reperfusion [J]. Ethnopharmacol, 2009, 121:412-418.

[61] 庄朋伟, 张艳军, 庞坦. 黄芩苷作用于脑微血管内皮细胞和星形胶质细胞对

神经干细胞分化的影响[J]. 中国组织工程研究与临床康复, 2009, 13(1):43-47

[62] 王文, 黄文婷, 艾厚喜, 等. 中药诱导脑成体神经干细胞的增殖分化[J].中国康复理论与实践, 2007, 13(1):26-28.

[63] 魏雁, 陈刚. 神经干细胞工程化的研究进展[J]. 中国组织工程研究与临床康复, 2009, 13(6):1159-1162.