Application of Aptamer Technology on the Biomedical Research

Abstract

Abstract: Aptamer, a specific oligonucleotide molecular obtained by systematic evolution of ligands by exponential enrichment (SELEX) , is a new class of molecular recognition element. It can specifically bind to target molecules. The affinity between target substance and matching aptamer is comparable with antigen-antibody binding. Multiple analysis and testing technologies based on the aptamer have been established, and widely applied in many fields including biochemical analysis, disease diagnosis, drug discovery and so on. Here, we will introduce the screening and characters of aptamer and the application in the area of biological molecular detection, disease biomarker. Finally, the application of aptamer on the research of nervous system diseases will be discussed.

Key words: aptamer, systematic evolution of ligands by exponential nrichment (SELEX), biochemical detection, disease diagnosis, nervous system disease

CLC Number:

R964

ZHAO Jie, ZHANG Qi, WANG Xu, HUA Qian, ZHANG Zi-jian. Application of Aptamer Technology on the Biomedical Research[J]. Acta Neuropharmacologica, 2014, 4(6): 44-54.

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