Long Noncoding RNAs：Research Strategies and Progresses in Neurodegenerative Diseases

Abstract

Abstract: Long noncoding RNAs (lncRNAs) are transcribed RNA molecules greater than 200 nucleotides in length. Nowadays, lncRNAs are found to have lots of functions including regulating transcription, post-transcriptional RNA processing, translation, nuclear factor transport, gene rearrangement and chromatin modification. Abnormal expressions of lncRNAs always come along with the pathogenesis of many diseases, such as cancer, neurodegenerative disorders, and cardiovascular disease. Thus a systematic and comprehensive profiling of lncRNA will help us to have a deeper understanding of the pathogenesis of the diseases. This article will focus on the research strategies of lncRNA and the latest progress in neurodegenerative diseases, which will contribute to the establishment of the regulation network of nervous system, and provide new ideas for the prevention of neurodegenerative diseases.

Key words: long noncoding RNAs, research strategy, neurodegenerative diseases, Alzheimer&, rsquo, s disease, Parkinson&, rsquo, s disease, Huntington&, rsquo, s disease, amyotrophic lateral sclerosis

CLC Number:

R964

Zhang Zhao, Chu Shi-feng, Huang Hui-yong, Chen Nai-hong. Long Noncoding RNAs：Research Strategies and Progresses in Neurodegenerative Diseases[J]. Acta Neuropharmacologica, 2014, 4(4): 42-49.

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