Effects of Osthole on Neuronal Apoptosis and Cell Cycle in AD Rats

Abstract

Abstract: Objective: To observe the influence of osthole on neuronal apoptosis and cell cycle in Alzheimer's disease (AD) rats and to study the neuroprotective effects and its mechanism. Methods: An intracerebroventricular (i.c.v.) injection of β-amyloid peptide (Aβ_25-35) was administrated to establish AD rat model. Osthole(12.5，25.0 mg·kg^-1) was injected intraperitoneally to rats and cognitive functions, neuronal apoptosis and cell cycle of AD rats were observed. Results: Osthole could improve spatial learning and memory abilities of AD rats, reduce neuronal apoptosis, increase the percentage of S phase cells, promote the G₂/M phase cells to divide further, strengthen the cell proliferation activity, regulate cell cycle and benefit to the maintenance of normal physiological function of neurons. Conclusion: Osthole hasneuronal protection through reducing neuronal apoptosis and regulating cell cycle, which may be one of mechanism of improving learning and memory disorder in AD rats.

Key words: osthole, Alzheimer&, rsquo, s disease, learning and memory, neuronal apoptosis, cell cycle

CLC Number:

R965

DONG Xiao-hua, MENG Xian-yong, ZHANG Li, YANG Jian-ming. Effects of Osthole on Neuronal Apoptosis and Cell Cycle in AD Rats[J]. Acta Neuropharmacologica, 2012, 2(3): 7-14.

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