ACTA NEUROPHARMACOLOGICA ›› 2011, Vol. 1 ›› Issue (6): 37-47.

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Progress in Understanding the Pathogenesis of Alzheimer’s Disease

XUE Xiao-yan1, GUO Xiao-hua2, LI-Min3, LUO Huan-min4   

  1. 1. Ganzhou People's Hospital, Ganzhou, 341000, China
    2. Gannan Medical University, Ganzhou, 341000, China
    3. Jiangxi Medical School, Nanchang, 330008, China
    4. Department of Pharmacology, School of Medicine, Jinan University, Guangzhou, 510632, China
  • Online:2011-12-26 Published:2013-04-25
  • Contact: 罗焕敏,男,教授;研究方向:神经药理学;Tel/Fax:+86-020-85220263,E-mail:tlhm@jnu.edu.cn
  • About author:薛小燕,女,硕士;研究方向:药学;E-mail:xuexiaoyan816@sina.com
  • Supported by:

    国家自然科学基金项目(No.30672450),广东省科技计划项目(No.2010B030700018)

Abstract: Although thepathogenesis of Alzheimer’s Disease (AD) is unclear, several hypotheses have been proposed, including the β-amyloid cascade theory, tau protein hypothesis, inflammation hypothesis and oxidative stress theory. This review summarized the widely-accepted new viewpoints on the pathogenesis of AD.

Key words: Alzheimer&, rsquo, S disease, pathogenesis, senile plaque, neurofibrillary tangle

CLC Number: