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26 October 2016, Volume 6 Issue 5 Previous Issue    Next Issue

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Effects of Loganin on MPTP-Induced Autophagy in PC12 Cells WANG Lin-fang，HUANG Shu-bing，XU Yi-da，CUI Chun，SHEN Yan-qin 2016, 6 (5):  14-21.  DOI: 10.3969/j.issn.2095-1396.2016.05.002 Abstract ( 733 )   PDF (9106KB) ( 318 )   Objective：To investigate the effects of loganin on MPTP-induced autophagy in PC12 cells. Methods：The autophagy model was established on PC12 cells by neurotoxin 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine（ MPTP）. The expression of autophagy-related factor microtubuleassociated protein1light chain 3-β（ LC3B） in PC12 cells was investigated at different concentrations and different time after MPTP administration. Then，the effects of loganin on the autophagy related signaling pathway induced by MPTP administration in PC12 cells were detected. Results：LC3B was significantly up-regulated at 12 h after MPTP treatment and the concentration of MPTP at 100 μg·mL-1 showed the strongest action on LC3B expression. Compared to MPTP treated group，the expression of LC3B was significantly down-regulated by loganin at dose of 200 μg·mL-1 combined with MPTP treatment. Furthermore，expression of lysosome associated membrane protein 2 （LAMP-2） was significantly downregulated by loganin at dose of 400 μg·mL-1 combined with MPTP treatment. Conclusions：MPTP at dose of 100 μg·mL-1 could induce the high expression of autophagy protein at 12 h after treatment. Loganin reduced expression of autophagosomes induced by MPTP in PC12 cells，and the inhibitory mechanism may be related to its enhancing digestion of lysosomes to autophagosomes. References | Related Articles | Metrics

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Advances of Targeted Drug Delivery Based on PEG-PCL SU Xiao-mei，ZHANG Dan-shen 2016, 6 (5):  22-28.  DOI: 10.3969/j.issn.2095-1396.2016.05.003 Abstract ( 731 )   PDF (7252KB) ( 330 )   In recent years，biodegradable materials have been widely used in pharmaceutical field because of the excellent biodegradability，biocompatibility and mechanical property. Among them，poly（ethylene glycol）-poly（ε-caprolactone） copolymers （PEG-PCL） has been widely used in drug delivery system. The drug delivery system based on PEG-PCL can be modified with various ligands，such as peptides，antibodies，carbohydrates，aptamers and small molecules for enhancing the bioavailability and therapeutic effect，achieving targeted drug delivery. In this paper，the research progress of targeted drug delivery based on PEG-PCL is reviewed，in order to provide ideas and methods for the applications of PEG-PCL in targeted drug delivery system. References | Related Articles | Metrics

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Study on the Therapeutic Effect of Traditional Chinese Medicine Compound on Alzheimer’s Disease DONG Yun-fang，WANG Peng-wen 2016, 6 (5):  29-33.  DOI: 10.3969/j.issn.2095-1396.2016.05.004 Abstract ( 684 )   PDF (4585KB) ( 420 )   Alzheimer's disease （AD） is the most common type of dementia. The incidence of AD increases year by year with the increase in the elderly population，and its mortality，morbidity and high cost of treatment are not only for patients themselves but also for their families members，caregivers and society to bring a heavy financial burden and care burden.But its pathological mechanism is complex，and the lack of effective treatment，and traditional Chinese medicine on the disease has a unique therapeutic advantage. This paper summarizes the related symptoms of AD the intervention and therapeutic effect of traditional chinese medicine compound preparation on various pathogenesis of AD in recent years. The results show that traditional chinese medicine compound preparation is an effective means to treat AD. References | Related Articles | Metrics

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Study on Chemical Constituents and Mechanism of Alkaloids in Treating Insomnia ZHANG Chun-hua, ZHAO Jing-min 2016, 6 (5):  34-38.  DOI: 10.3969/j.issn.2095-1396.2016.05.005 Abstract ( 851 )   PDF (972KB) ( 340 )   Objective：To review the advances in the treatment of insomnia with alkaloids，in order to accelerate the development of new anti-insomnia drugs. Methods：To review the research literatures in recent years，to sort out the research results of alkaloid components in the treatment of insomnia，and to illustrate the role of alkaloid components in the treatment of insomnia. Results：The alkaloids extracted from natural drugs effected the treatment of insomnia significantly. Conclusion：Alkaloid have made remarkable achievements in the treatment of insomnia，anti-insomnia effect of natural drugs containing alkaloids needs further research and development. References | Related Articles | Metrics

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Progress on Research of 5-Lipoxygenase in Alzheimer’s Disease DU Guan-tao，ZHANG Chun-teng，HONG Hao 2016, 6 (5):  39-44.  DOI: 10.3969/j.issn.2095-1396.2016.05.006 Abstract ( 828 )   PDF (6094KB) ( 337 )   5-lipoxygenase plays a key role in catalyzing the conversion of arachidonic acid （AA） to 5-hydroperoxy-6，8，11，14-eicosatetraenoic acid （5-HPETE），which can then be metabolized into different leukotrienes （LTs）. The recently studies have shown that 5-lipoxygenase is involved in the pathophysiology of Alzheimer’s disease. Inhibition of 5-lipoxygenase decreases amyloid β peptide （Aβ） and tau hyperphosphorylation，mitigates neuroinflammation，regulates synaptic function and ameliorates cognitive disorders in Alzheimer’s disease. In this review，we will summarize studies of 5-lipoxygenase in Alzheimer’s disease pathogenesis. References | Related Articles | Metrics

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Research Progress on Pinocembrin：Potential Therapeutic Applications and Action Mechanisms Zhang Hai-wei，Zhang Li 2016, 6 (5):  45-52.  DOI: 10.3969/j.issn.2095-1396.2016.05.007 Abstract ( 695 )   PDF (8854KB) ( 288 )   Pinocembrin is a natural flavonoid compound extracted from propolis，ginger plants，wild marjoram，and other plants which have a higher content. In the preclinical studies，it has shown anti-inflammatory，anti-tumor，antioxidant，decrease blood lipids，neuroprotective effects and other pharmacological effects. In recent domestic and foreign studies focused on pinocembrin neuroprotective effects as well as the ability to attenuate reactive oxygen species，protect the blood-brain barrier，modulate mitochondrial function，and regulate apoptosis. Pinocembrin is a potential drug to treat ischemic stroke and other clinical conditions. In this review，we summarize its pharmacokinetics，mechanisms of action and potential therapeutic applications，in order to provide a reference for pinocembrin mechanisms research and therapeutic applications. References | Related Articles | Metrics

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Progress in Genetic Factors for Male Infertility CHEN Wen-yang, SHEN Li-xia, ZHANG Gui-rong 2016, 6 (5):  53-64.  DOI: 10.3969/j.issn.2095-1396.2016.05.008 Abstract ( 601 )   PDF (1070KB) ( 261 )   Male infertility was caused by mutiple factors，including both genetic and environmental factors. Nearly 50% of clinic male infertility disorders were from genetic defects，which had shown mainly four different variation hierarchies，aneuploid chromosome variation，structural chromosome variation，gene copy number variation and single gene mutation. In recent years the increasingly deep recognition of genetic male infertility has been witnessed. This review summarizes the research progress of the genetic factors for male infertility on the aspects of epidemiology，mechanisms and pathological changes，from aforesaid four different variations. References | Related Articles | Metrics