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26 December 2016, Volume 6 Issue 6 Previous Issue    Next Issue

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The Action and Molecular Mechanisms of MicroRNA-195 on Cognitive Decline Induced by Chronic Brain Hypoperfusion ZHANG Shuai，SUN Li-hua，AI Jing 2016, 6 (6):  1-22.  DOI: 10.3969/j.issn.2095-1396.2017.06. 001 Abstract ( 931 )   PDF (43368KB) ( 444 )   Chronic brain hypoperfusion （CBH） is a common clinical manifestation of vascular dementia （VD）. Clarifying the effects of CBH on cognitive function would help to improve our understanding the pathophysiological mechanism of VD and provide the possible therapeutic strategy for VD. In recent years， our group focused on to investigate the action and molecular mechanisms of CBH on learning and memory ability of rats using a CBH model by bilateral common carotid artery occlusion （or called two-vessel occlusion，2VO）. We found that miR-195 could regulate cognitive ability of CBH rats through targeting on varies genes simultaneously that associated with all three pathological processes including amyloid β peptide （Aβ） deposition， tau hyperphosphorylation， dendritic degeneration and neuronal loss. Importantly，miR-195 could not only prevent the initial amyloidogenic cascade response via downregulating amyloid precursor protein （APP） and β-site APP cleaving enzyme 1 （BACE1）， but also provide sufficient requisite substrates during the amyloidogenic cascade response process. In addition，our series studies also provide evidence that miRNAs could participate in the onset and the development processes of diseases by regulating multi-targets within one functional module. References | Related Articles | Metrics

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Research Progress on Encapsulation Efficiency of Liposomes ZHAO Kai-yan， ZHANG Dan-shen 2016, 6 (6):  23-30.  DOI: 10.3969/j.issn.2095-1396.2016.06. 002 Abstract ( 1288 )   PDF (8795KB) ( 462 )   Liposomes are vesicles composed of phospholipid bilayers surrounding an aqueous compartment. It is possible to encapsulate not only hydrophilic drugs in the inner aqueous compartment， but also lipophilic compounds in the lipidic double layer. Lipidic double layer is ideal for drug delivery to the human body， due to the similarity with natural cells. Its application is important to the diagnosis and treatment of nervous system diseases，malignant tumors， hereditary diseases and so on. When designing and developing a liposome formulation， it is important to control the encapsulation efficiency. High drug encapsulation is a very important characteristic. Furthermore， evaluation of EE is a regulatory requirement. Herein， our aim is to review the relevant papers in the literature on method for determination of entrapment efficiency and discuss the effect of the lipid membrane composition， phospholipid chain length， charge， and different liposome preparation methods on the encapsulation efficiency. References | Related Articles | Metrics

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Progress in the Relationship of Apolipoprotein E4 on Alzheimer’s Disease GAO Jin-chao, ZHAO Wen-juan, YIN Ming 2016, 6 (6):  31-39.  DOI: 10.3969/j.issn.2095-1396.2016.06. 003 Abstract ( 800 )   PDF (8076KB) ( 368 )   Alzheimer’s disease（AD） is a progressive neurodegenerative disorder， but the pathogenesis of AD is still complicated and indeterminate. In recent decades， evidence indicates that apolipoprotein E4（ApoE4） is a multifunctional protein with central roles in lipid metabolism which also plays an important role in AD. Here we review recent progress on the relationship between ApoE4 and AD. References | Related Articles | Metrics

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Research Progress on the Correlation Between Alzheimer’s Disease and Depression DU Guan-tao， LIN Jing-ran,LIU Guang-jun， HONG Hao 2016, 6 (6):  40-44.  DOI: 10.3969/j.issn.2095-1396.2016.06. 004 Abstract ( 814 )   PDF (5014KB) ( 508 )   Increasing evidence shows that Alzheimer’s disease （AD） is closely associated with depression. Depression is an important risk factor of AD and depressive symptoms often occur among patients with AD. This review focused on the relationship of these two diseases and summarized the underlying pathological mechanisms， including vascular factor， β-amyloid protein， glucocorticoid steroids and hippocampal atrophy， nerve growth factors and excitatory amino acid， which may provide a new insight into developing novel treatment strategies for AD and depression. Related Articles | Metrics

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An Overview of the Transporters for the Neurodrugs Based on the Blood-Brain Barrier XU Wei-zhe，LI Xiao-rong，XIONG Jie，XU Ping-xiang，XUE Ming 2016, 6 (6):  45-54.  DOI: 10.3969/j.issn.2095-1396.2016.06. 005 Abstract ( 702 )   PDF (10585KB) ( 384 )   The drug transporters are membrane transport proteins that are present in all organisms. These transporter proteins control the influx and efflux of endogenous and exogenous components including drugs， resulting in the critical roles in cellular substance homeostasis. The blood-brain barrier （BBB） from the systemic circulation represents a barrier to affect the uptake and output of both endogenous compounds and xenobiotics into or out of brain. Members of the solute carrier and ATP-binding case families are present on these barriers. Differences exist in the localization and expression of these transport proteins on the BBB， resulting in functional differences in the properties of the transport and plasma drug concentrations， effects and toxicities for the neuropsycho-drugs. This review focuses on the research overview of drug transporters based on the BBB with the neuropsycho-diseases. References | Related Articles | Metrics

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Mechanisms of Autism Spectrum Disorder and Pharmacological Approach LONG Sen，CHEN Jia-ye，HAN Feng 2016, 6 (6):  55-64.  DOI: 10.3969/j.issn.2095-1396.2016.06. 006 Abstract ( 814 )   PDF (10482KB) ( 367 )   Autism spectrum disorder （ASD） is a heterogeneous group of bio-neurological developmental disorders that displays common behavioral symptoms， including pervasive impairments in social interactions， accompanied by communication challenges and repetitive behaviors. Present review highlighted the advances on molecular mechanisms of autism， also summary the present pharmacological interventions for abnormal symptoms during ASD clinical therapy. References | Related Articles | Metrics