Research Progress on the Role of Hydrogen Sulfide in the Central Nervous System

Abstract

Abstract: Hydrogen sulfide (H2S) is the third gas signal molecule followed by nitric oxide (NO) and carbon monoxide (CO), which is produced by special enzyme catalysis in the body and has specific metabolic process. It plays an important role in the central nervous system. It participates in many nervous functions such as long-term potentiation of hippocampus and the role of the glial cell activity. It impacts the hypothalamus - pituitary - adrenal axis, participates in the regulation of neuronal oxidative stress reaction and cerebrovascular function in the physiologicalstate. It is also involved in a variety of central nervous system diseases such as Alzheimer's disease, head-induced seizure, Down syndrome, and the pathophysiological processes of cerebral ischemia and cerebral ischemia reperfusion. In this paper, we reviewed the research progress of H2S in the central nervous system.

Key words: Hydrogen sulfide, Central nervous system, cerebral ischemia, mechanisms

CLC Number:

R964

LI Guo-feng, LUO Hai-kun, ZHANG Jian-xin. Research Progress on the Role of Hydrogen Sulfide in the Central Nervous System[J]. Acta Neuropharmacologica, 2014, 4(3): 49-56.

References

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[1] 蒋元强，姜永根，孙中兴. 一起硫化氢中毒死亡事故调查[J]. 职业卫生与应急救援，2013，31(6): 306-307.

[2] 王建菊，方绍峰，周世义，等. 某化纤厂三起急性硫化氢中毒事故调查分析[J].职业卫生与应急救援，2014，31(2): 109-110.

[3] Goodwin L R, Francom D, Dieken F P, et al. Determination of sulfide in brain tissue by gas dialysis/ion chromatography: postmortem studies and two casereports[J]. J Anal Toxicol, 1989, 13(2): 105-109.

[4] Kazuho Abe, Hideo Kimura. The possible role of hydrogen sulfide as an endogenous neuromodulator[J]. Neurosci, 1996, 16(3): 1066-1071.

[5] Zhang Xing-zhou, Jin-song S Bian. Hydrogen sulfide: a neuromodulator and neuroprotectant in the central nervous system [J]. ACS Chem Neurosci, 2014, 5(10): 876-883.

[6] Kamoun P. Endogenous production of hydrogen sulfide in mammals[J]. Amino Aeiels, 2004, 26(3): 243-254.

[7] 刘芳，刘广杰，张建新，等. 外源性硫化氢对大鼠急性心肌缺血损伤时炎性反应的影响[J]. 中华麻醉学杂志, 2014, 34(2): 227-229.

[8] Hideo Kimura. Hydrogen sulfide: from brain to gut[J]. Antioxid Redox Signal, 2010, 12(9): 1111-1123.

[9] Norihiro Shibuya, Makiko Tanaka, Mikiharu Yoshida, et al. 3-Mercaptopyruvate sulfur Transferase produces hydrogen sulfide and bound sulfane sulfur in the brain[J]. Antioxid Redox Signal, 2009, 11(4): 703-714.

[10] Ko Eto, Hideo Kimura. The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain [J]. J Neurochem, 2002, 83 (1): 80-86.

[11] Bao Li-ming, Cestmi Vleek, Vaclav Paces, et al. Idetification and tissue distribution of human cystathionine beta-synthase mRNA isoforms[J]. Arch Biochem Biophys, 1998, 350 (1): 95-103.

[12] Caroline J Richardson, Elizabeth A M Magee, John H Cwmmings. A new method for the determination of sulphide in gastrointestinal contents and whole blood by microdistillation and ion chromatography[J]. Clin Chim Acta, 2000, 293 (1-2): 115-125.

[13] Bang Rui. The gasotransmitter role of hydrogen sulfide[J]. Antioxid Redox Sianal, 2003, 5(4): 493-501.

[14] Julie Furne, Aalia Saeed, Michael D Levitt. Whole tissue hydrogen sulfide concentr-ations are orders ofmagnitude lower than presently accepted values[J]. Am J Physiol Regul Integr Comp Physiol, 2008, 295(5): 1479-1485.

[15] Ogasawara Y, Ishii K, Togawa T, et al. Determination of bound sulfur in serum by gas dialysis/high-performance liquid chromatography[J]. Anal Biochem, 1993, 215(1): 73-81.

[16] Toohey J I. Sulphane sulphur in biological systems: A possible regulatory role[J]. Biochem J, 1989, 264(3): 625-632.

[17] Wang Rui. Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter? [J]. FASEB, 2002, 16(13): 1792- 1798.

[18] Martha H Stipanuk. Sulfuramino acid metabolism pathways for production and removal of homocysteine and cysteine[J]. Annu Rev Nutr, 2004, 24:539-577.

[19] Ko Eto, Miki Ogasawara, Ken Umemura, et al. Hydrogen sulfide is produced in response to neuronal excitation[J]. J Neurosci, 2002, 22(9): 3386-3391.

[20] Moonhee Lee, Claudia Schwab, Yu Sheng, et al. Astrocytes produce the anti-inflammatary and neuroprotective agent hydrogen sulfide[J]. Neurobiol Aging, 2009, 30 (10): 1523-1534.

[21] Yasushi Enokido, Eri Suzuki, Kazu Iwasawa, et al. Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse[J]. FASEB J, 2009, 19 (13): 1854-1856.

[22] Shiau Wei Lee, Yvonne Cheng, Philip K Moore, et al. Hydrogen sulphide regulates intra- cellular pH in vascular smooth muscle cells[J]. Biochem Biophys Res Commun, 2007, 358(4): 1142-1147.

[23] Lu Ming, Chooi Hoong Choo, Hu Li-fang, et al. Hydrogen sulfide regulates intracellular pH in ratprimary cultured glia cells[J]. Neurosci Res, 2010, 66(1): 92-98.

[24] 代政伟, 晏勇, 张华, 等. 硫化氢与神经胶质细胞功能的研究进展[J]. 中国老年学杂志, 2011, 31(3): 1072-1074.

[25] Yasuo Nagai, Mamiko Tsugane, Jun-Ichiro Oka, et al. Hydrogen sulfide induces calcium waves in astrocytes[J]. FASEB J, 2004, 18(3): 557-559.

[26] Shiau Wei Lee, Ye-Shi Hu, Hu Li-fang, et al. Hydrogen sulphide regulates calcium homeostasis inmicroglial cells[J]. Glia, 2009, 54(2): 116-124.

[27] Oh Gi-su, Pae Hyun-Ock, Lee Bok-Soo, et al. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via hemeoxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide[J]. Free Radic BiolMed, 2006, 41(1): 106-119.

[28] Ki Kyung Jung, Hae Sung Lee, Jae Youl Cho, et al. Inhibitory effect of curcumin on nitricoxide production from lipopolysaccharide-activated primary microglia[J]. Life Sci, 2006, 79(21): 2022-2031.

[29] Laura Rinaldi, Giuliana Gobbi, Maurizia Pambianco, et al. Hydrogen sulphide prevents apoptosis of human PMN via inhibition of p38 and caspase 3[J]. Lab Invest, 2006, 86(4): 391-397.

[30] Dello Russo C, Tringali G, Ragazzoni E, et al. Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function: in vitro and in vivo studies in the rat[J]. J Neuroendocrinol, 2000, 12(3): 225-233.

[31] 刘登群, 胡志安. 中枢神经系统H2S的作用及机制研究进展[J]. 生理科学进展, 2004, 35(2): 170-173.

[32] Navarra P, C Dello Russo, Mancuso C, et al. Gaseous neuromodulat ors in the control of neuroen docrine stress axis [J]. Ann N Y Acad Sci, 2000, 917(1): 638- 646.

[33] Yuka Kimura, Hideo Kimura. Hydrogen sulfide protects neurons from oxidative stress[J]. FASEB J, 2004, 18(10): 1165-1167.

[34] Kimura Y, Goto Y I, Kimura H. Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria[J]. Antioxid Redox Signal, 2010, 12(1): 1-13.

[35] Matthew Whiteman, Jeffrey S Armstrong, Siew Hwa Chu, et al. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'? [J] J Neurochem, 2004, 90(3): 765-768.

[36] 杨丝丝, 姜志胜, 唐小卿. 硫化氢对H2O2损伤PC12细胞的保护作用[J]. 南华大学学报: 医学版, 2007, 35(4): 491-494.

[37] 廖新学, 唐小卿, 郭瑞鲜, 等. ATP敏感钾通道在硫化氢钠对抗β-淀粉样肽诱导细胞损伤中的作用[J]. 中山大学学报: 医学科学版, 2008, 29(3): 258-263.

[38] Cheng You-qin, Joseph Fomusi Ndisang, Tang Guang-hua, et al. Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats[J]. Am J Physiol Heart Circ Physiol, 2004, 287(5): H2316-2323.

[39] 张建华, 陈志武.大鼠脑基底动脉舒张作用的EDHF机制及杜鹃花总黄酮的作用[D]. 中国博士学位论文数据库, 2009: 1-8.

[40] 周方杰, 陈志武. 硫化氢介导的大鼠大脑中动脉的内皮源性超极化因子反应[J]. 安徽医科大学学报, 2011, 46(8): 768-771.

[41] Wen Xiang-ru, Qi Da-shi, Sun Ying, et al. H2S attenuates connitive deficits through Akt1/jnk3 signaling pathway in ischemic stroke[J]. Behav Brain, 2014, 269(1): 6-14.

[42] Qu Kun, Christopher Chen, Barry Halliwell, et al. Hydrogen sulfide is a mediator of cerebral ischemic damage[J]. Stroke, 2006, 37(3): 889-893.

[43] 李国风, 张建新, 骆海坤, 等. 氨基氧乙酸对大鼠局灶性脑缺血损伤的影响[J]. 中华麻醉学杂志, 2011, 31(8): 984-986.

[44] Guo-Feng Li, Hai-Kun Luo, Lan-Fang Li, et al. Dual effects of hydrogen sulphide on focal cerebral ischaemic injury via modulation of oxidative stress-induced apoptosis[J]. Clin Exp Pharmacol Physiol, 2012, 39(9)：765-771.

[45] 张萌，李国风，骆海坤，等.外源性硫化氢对大鼠局灶性脑缺血时线粒体功能的影响[J]. 中华麻醉学杂志，2014，10: 1259-1262.

[46] 任彩丽, 李东亮, 赵红岗，等. 全脑缺血-再灌注大鼠脑组织内源性硫化氢的动态变化[J]. 中国脑血管病杂志, 2008, 4(5): 177-181.

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