Translesion DNA Synthesis and Its Potential Role in Cancer Therapy

Abstract

Abstract: Translesion DNA synthesis (TLS) is an evolutionarily conserved mechanism of DNA damage tolerance in response to DNA damage, which utilizes specialized DNA polymerases to replicate damaged DNA templates. As TLS can tolerate DNA damages, decrease the sensitivity of cancer cells to chemotherapy drugs or ionizing radiation, it is a potential mechanism for cancers to develop drug resistance or radiation resistance. Therefore, it is plausible to target TLS pathway to enhance the therapeutic effect on patients with different tumors, including glioblastoma.

Key words: Translesion DNA synthesis, TLS polymerases, Drug resistance, Synthetic lethality, Glioblastoma

CLC Number:

R964

Huang Min, Tang Tie-shan, Guo Cai-xia. Translesion DNA Synthesis and Its Potential Role in Cancer Therapy[J]. Acta Neuropharmacologica, 2014, 4(5): 36-43.

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