The Correlation of General Anesthetic and Memory

Abstract

Abstract: General anesthetics are a class of drugs that have the ability to induce loss of consciousness and feeling, muscle relaxation and memory blockade, by reversibly inhibiting the central nervous system. Anesthetics target different receptors and brain regions to modify the various forms of memory. There are some patients with amnesia or even postoperative cognitive dysfunction. The effects of general anesthesia on memory seem to be related to the types of memory, age of the experimental subjects, the species and doses of the drug, and the types of the surgery. The underlying cellular substrates include γ-aminobutyric acid subtype A receptor, excitatory amino acid and synaptic plasticity.

Key words: general anesthetic, memory, ostoperative cognitive dysfunction, synaptic plasticity, &, gamma, -aminobutyric acid subtype A receptor, excitatory amino acid

CLC Number:

R964

WU Miao-miao, LI Wei, DONG Xiao-hua, ZHANG Dan-shen. The Correlation of General Anesthetic and Memory[J]. Acta Neuropharmacologica, 2013, 3(6): 48-56.

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