Acta Neuropharmacologica

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Role of N-Methyl-D-Aspartate Receptor in Memory Network

ZHANG Dan-shen,SU Xiao-mei   

  1. 1. College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang,050000,China
    2. Department of Pharmacology,Hebei Medical University,Shijiazhuang,050000,China
  • Online:2019-02-26 Published:2020-01-09
  • About author:张丹参,女,博士生导师;研究方向:神经药理学;Tel: +86-0311-81668016,E-mail: zhangds2011@126.com
  • Supported by:
    河北省自然科学基金项目(No.H2016208058),河北省高等学校科学技术研究项目(No.ZD2016009)

Abstract: N-methyl-D-aspartate (NMDA) receptors belong to glutamate ionic receptor, which are implicated in synaptic plasticity,specifically in learning and memory process. NMDA receptors are involved in learning and memory in the central nervous system,such as receptors and transmitters represented by choline receptors,adenosine A1 receptors and so on;amino acid neural pathways represented by glutamate;intracerebral neuroelectric activity represented by long-term potentiation;changes of genetic proteins represented by brain-derived neurotrophic factor;even the neurotoxicity of glutamate in neurodegenerative diseases and so on. The function of learning and memory is regulated by the changes of NMDA receptors,and then affect the whole central nervous system. In other words,if we consider the information transmission system of learning and memory as a huge information network,the NMDA receptors will be the key point of the network. Therefore, the evaluation of the role of NMDA receptors in learning and memory network should start from the association of NMDA receptors and network,based on micro-research and guided by macro-analysis, to lead to further research of brain function and related disease systems.

Key words: N-methyl-D-aspartate, receptor, memory

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