Methods and Evaluation of Animal Models of Cerebral Ischemia and Cerebral Ischemia Reperfusion Injury

Abstract

Abstract: Cerebrovascular disease is a clinically common disease and frequently-occurring disease. The selection and application of reliable animal models are particularly important in studies for the prevention and treatment of cerebrovascular disease. The types, operation procedures of models, and characteristics of the global cerebral and focal cerebral ischemia and cerebral ischemia reperfusion injury in different animal models were discussed in detail in this paper. The improved Himori method (the model of cerebral ischemia reperfusion was produced in mice by temporarily obstructing bilateral common carotid arteries) and some key steps were especially presented in detail. The evaluation of the application characteristics of existing animal models will help to select the appropriate models of cerebral ischemia and cerebral ischemia reperfusion for studying cerebrovascular disease.

Key words: cerebral ischemia, cerebral ischemia reperfusion, animal models, improved Himori method, preparation methods, evaluation

CLC Number:

R743.3

Wang Shu, Zhang Li. Methods and Evaluation of Animal Models of Cerebral Ischemia and Cerebral Ischemia Reperfusion Injury[J]. Acta Neuropharmacologica, 2011, 1(3): 31-40.

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