Mitochondria and Neurodegenerative Diseases

Abstract

Abstract: The neurodegenerative diseases are usually caused by the loss of the neurons and/or their myelin sheath, but the pathogenesis of these diseases are still indeterminate. Studies so far has proved that mitochondrial dysfunction and energy metabolism disorders are early pathological phenomena. This review concentrates on two of the most prevalent neurodegenerative diseases: Alzheimer’s disease (AD) and Parkinson’s disease (PD) and would be aimed to discuss the role of mitochondrial in pathogenesis of neurodegenerative diseases, providing new direction for further research.

Key words: mitochondrion, Alzheimer&, rsquo, s disease, Parkinson&, rsquo, s disease

CLC Number:

R741

Zhou Xiao-wen, Su Chao-fen, Luo Huan-min. Mitochondria and Neurodegenerative Diseases[J]. ACTA NEUROPHARMACOLOGICA, 2011, 1(3): 41-46.

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