Methods and Evaluation of Animal Models of Induced Silicosis

doi:10.3969/j.issn.2095-1396.2019.06.005

Abstract

Abstract:

Silicosis is an occupational disease mainly caused by pulmonary fibrosis caused by long-term inhalation of high concentrations of dust during the production process. It is the most common occupational disease. The pathogenesis of silicosis has been studied at home and abroad for a long time. It is essential to explore the pathogenesis of silicosis，study treatment methods，and establish animal models. This article provides a more comprehensive selection of clinical research applications for silicosis through a relatively comprehensive introduction to silicosis animal models.

Key words: silicosis, animal model, silica, evaluation

CLC Number:

R967

ZHANG Dan-shen，JIN Shan. Methods and Evaluation of Animal Models of Induced Silicosis[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.06.005.

References

1 魏伟, 吴希美, 李元建. 药理实验方法学. [M]. 北京：第4版. 人民卫生出版社, 2010.
2 邢玲香. 新发尘肺病例发病特点分析[J].世界最新医学信息文摘, 2016, 16(A3): 61-62.
3 许东, 吴逸明, 王鹏, 等. 朱燃.兔尘肺模型制备与肺灌洗方法的研究[J].中华劳动卫生职业病杂志, 2002, 20(2): 54-56.
4 王莹, 邓国祥. 实验动物矽肺不同时段CT与病理学表现对比[J]. 山西医科大学学报, 2008, 39(9): 787-790.
5 向军俭, 孙佳寅, 邓宁, 等. 小鼠矽肺模型的建立及bFGF参与矽肺形成的研究[J]. 中国病理生理杂志, 2004, 20(4):647-650.
6 郑振辉, 周淑佩, 彭双清. 实用医学实验动物学[M]. 北京：北京大学医学出版社, 2008.
7 李永强, 粟永萍, 李蓉, 等. 建立矽肺犬动物模型的实验研究[J].第三军医大学学报, 2012, 34(12): 1189-1191.
8 乔俊华. 大鼠煤工尘肺动物模型的研究[D]. 长春:吉林大学, 2009.
9 邹昌淇, 杜庆成, 周培宏. 联合用药治疗大鼠早期矽肺的疗效观察[J].中华劳动卫生职业病杂志, 2001, 19(1): 12-14.
10 Guo Jing-wen, Yang Zhi-feng, Jia Qiang, et al. Pirfenidone inhibits epithelial-mesenchymal transition and pulmonary fibrosis in the rat silicosis model[J]. Toxicology Letters, 2019, 300: 59-66.
11 Kosuke Kato, Marina A Zemskova, Alec D Hanss, et al. Muc1 deficiency exacerbates pulmonary fibrosis in a mouse model of silicosis[J]. Biochemical and Biophysical Research Communications, 2017: 493(3): 1230-1235.
12 Chen Ying, Chen Jie, Dong Jing, et al. Antifibrotic effect of interferon gamma in silicosis model of rat[J]. Toxicology Letters, 2005, 155(3):353-360.
13 Robert M Lassance, Luiz Felipe M Prota, Tatiana Maron-Gutierrez, et al. Intratracheal instillation of bone marrow-derived cell in an experimental model of silicosis[J]. Respir Physiol Neurobiol, 2009, 169(3):227-233.
14 Wang Yan, Yang Geng-xia, Zhu Zhong-hui, et al. Effect of bone morphogenic protein-7 on the expression of epithelial–mesenchymal transition markers in silicosis model[J]. Experimental and Molecular Pathology, 2015, 98(3):393-402.
15 顾志娟, 张永林. 兔煤工尘肺模型HRCT表现与病理学对照研究[J]. 中国现代医生, 2012, 50(12):91-93.
16 吴逸明,许东,徐玉宝,等.无损伤性兔矽肺模型制备[J].中国职业医学, 2002, 29(4): 52-53.
17 蒲新明, 温浩, 刘新军, 等. 小型猪矽肺模型制备与肺灌洗方法研究[J]. 中国职业医学, 2013, 40(1):47-49.
18 Elyse Bissonnette, Marek Rola-Pleszczynski. Pulmonary inflammation and fibrosis in a murine model of asbestosis and silicosis. Possible role of tumor necrosis factor[J]. Inflammation, 1989, 13(3):329-339.
19 尹汝泉, 邹昌淇, 胡天锡. 汉防已甲素对猴实验性矽肺的疗效和毒性观察[J].卫生研究, 1982(4): 55-65.
20 王明臣, 胡婵丽, 董子明, 等. 煤工尘肺患者血清CuZn-SOD和铜蓝蛋白活性研究[J]. 环境与职业医学, 2005, 22(4):357-358.
21 王莹, 邓国祥.实验动物矽肺影像研究[J].山西医科大学学报, 2008, 39(8): 714-716.
22 李秋营, 张慧峰. 穿刺式气管内注入染尘的方法[J]. 山西医科大学学报, 1995, 26(1):73-74.
23 谷仿丽, 陈乃富, 鲁山, 等. 矽肺大鼠模型的动态研究[J]. 海峡药学, 2009, 21(7):65-67.
24 周效宝, 张玮, 王瑞, 等. 染矽尘大鼠早期肺组织病理变化观察[J]. 工业卫生与职业病, 2012, 38(1):4-8.
25 谢英, 李智民, 沙焱. 尘肺病动物模型建立的研究进展[J]. 职业卫生与应急救援, 2018, 36(05):28-30, 74.
26 王晔, 杨茜, 程薇波, 等. 用HOPE-MED8050动式染尘控制系统建立大鼠矽肺模型[J]. 环境与职业医学, 2013, 30(7): 551-554.
27 高学敏,耿玉聪,李世峰,等.动式染尘构建矽肺大鼠模型及ACE2-Ang(1-7)-Mas轴动态变化规律[J].医学研究生学报, 2016, 29(12): 1276-1280.
28 张琪凤, 钱蕙兰. 几种染尘方法的比较第一报肺脏中粉尘均匀性的比较[J]. 浙医学报, 1965(2):5-8.
29 Eman Said, Manar Helal. Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling[J]. International Immunopharmacology, 2019, 70: 47–55.
30 姜岩, 张娟, 贾强, 等. 气管插管法建立矽肺大鼠模型方法的改进[J].现代预防医学, 2017, 44(22): 4160-4164, 4167.

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