Progress in the Relationship of Apolipoprotein E4 on Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2016.06. 003

Abstract

Abstract: Alzheimer’s disease（AD） is a progressive neurodegenerative disorder， but the pathogenesis of AD is still complicated and indeterminate. In recent decades， evidence indicates that apolipoprotein E4（ApoE4） is a multifunctional protein with central roles in lipid metabolism which also plays an important role in AD. Here we review recent progress on the relationship between ApoE4 and AD.

Key words: apolipoprotein E4, Alzheimer&, rsquo, s disease, &, beta, -amyloid protein, treatment target

GAO Jin-chao, ZHAO Wen-juan, YIN Ming. Progress in the Relationship of Apolipoprotein E4 on Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(6): 31-39.

References

[1] Prince Martin, Adelina Comas-Herrera, Martin Knapp, et al. World Alzheimer report 2016: improving healthcare for people living with dementia: coverage, quality and costs now and in the future [R]. London: Alzheimer’s Disease International (ADI), 2016: 84-104.

[2] De Strooper Bart, Eric Karran. The cellular phase of Alzheimer’s disease [J]. Cell, 2016, 164(4): 603-615.

[3]Jeffrey Cummings, Paul S Aisen, Bruno DuBois, et al. Drug development in Alzheimer’s disease: the path to 2025 [J]. Alzheimer's Research & Therapy, 2016, 8(1): 39.

[4] Shubham Misra, Bikash Medhi. Drug development status for Alzheimer’s disease: present scenario [J]. Neurol Sci, 2013, 34(6): 831–839.

[5] Kevin M Felsenstein, Kate M Candelario, Dennis A Steindler, et al. Regenerative medicine in Alzheimer’s disease [J]. Translational Research, 2014, 163(4): 432-438

[6] John Hardy, Dennis J Selkoe. The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics [J]. Science, 2002， 297(5580):353-356.

[7] Maria Laura Giuffrida, Filippo Caraci, Bruno Pignataro, et al. Beta-amyloid monomers are neuroprotective [J]. J Neurosci, 2009, 29(34):10582-10587

[8] Olaf Bergmann, Jonas Frisén. Why adults need new brain cell [J]. Science, 2013, 340(6133): 695-670.

[9] Fiona Doetsch. A niche for adult neural stem cells [J]. Curr Opin Genet Dev, 2003, 13(5): 543-550.

[10] Roland Coras, Florian Siebzehnrubl, Elisabeth Pauli, et al. Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans [J]. Brain, 2010, 133(11):3359-3372.

[11] Claudia Lieberwirth, Pan Yong-liang, Liu Yan, et al. Hippocampal adult neurogenesis: Its regulation and potential role in spatial learning and memory [J]. Brain Research, 2016 1644: 127-140.

[12] Tincer Gizem, Violeta Mashkaryan, Prabesh Bhattarai, et al. Focus: The Aging Brain: Neural stem/progenitor cells in Alzheimer’s disease[J]. J Yale of Biology and Medicine, 2016, 89(1): 23.

[13] Abdel-Salam OME. Stem cell therapy for Alzheimer’s disease [J]. CNS & Neurological Disorders-Drug Targets, 2011, 10(4):459-485.

[14] Chen Qian, Akira Nakajima, Se Hoon Choi, et al. Adult neurogenesis is functionally associated with AD-like neurodegeneration [J]. Neurobiol Dis, 2008, 29(2):316-326.

[15] He N, Jin Wei-lin, Lok Keng Hoe, et al. Amyloid-b1–42 oligomer accelerates senescence in adult hippocampal neural stem/progenitor cells via formylpeptide receptor 2 [J]. Cell Death and Disease, 2013, 4(11):e924.

[16] Jin Kun-lin, Alyson L Peel, Xiao ou Mao, et al. Increased hippocampal neurogenesis in Alzheimer’s disease [J]. PNAS 2004, 101(1):343-347.

[17] Iryna Ziabreva, Elaine Perry, Robert Perry, et al. Altered neurogenesis in Alzheimer’s disease [J]. J Psychosom Res, 2006, 61(3):311-316.

[18] Li Bin, Hidenaga Yamamori, Yoshitaka Tatebayashi, et al. Failure of neuronal maturation in Alzheimer disease dentate gyrus [J]. J Neuropathol Exp Neurol, 2008, 67(1):78-84.

[19] Wesley W Chen, Mathew Blurton-Jones. Concise review: can stem cells be used to tread or model Alzheimer’s disease? [J] Stem Cells, 2012, 30(12):2612-2618.

[20] Lee Ji Han, Il-Hoan Oh, Hyun Kook Lim. Stem Cell Therapy: A Prospective Treatment for Alzheimer's Disease [J]. Psychiatry Investigation, 2016, 13(6): 583-589.

[21] Dennis Steindler, Tareck Kadrie, Helen Fillmore, et al. The subepenedymal zone: “brain marrow” [J]. Prog Brain Res, 1996, 108: 349-363.

[22] Reynolds B A, Weiss S. Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system [J]. Science, 1992, 255(5052):1707-1710.

[23] Dana Alliance Steindler, Pincus DW. Stem cells and neurogenesis in the adult human brain [J]. Lancet, 2002, 359(9311):1047-1054.

[24] Ivy S Samuels, J Colleen Karlo, Alicia N Faruzzi, et al. Deletion of ERK2 motogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function [J]. J Neurosci, 2008, 28(27):6983-6995.

[25] Zhang Chun-li, Zou Yu-hua, He Wei-min, et al. A role for adult TXL-positive neural stem cells in learning and behavior [J]. Nature, 2008, 451(7181):1004-1007.

[26] Malcolm Maden. Retinoic acid in the development, regeneration and maintenance of the nervous system [J].Nat Rev Neurosci, 2007, 8(10):755–765.

[27] Phedias Diamandis, Jan Wildenhain, Ian D Clarke, et al. Chemical genetics reveals a complex functional ground state of neural stem cells [J].Nat Chem Biol, 2007, 3(5):268–273

[28] Maria Frank-Kamenetsky, Zhang Xiao-yan, Steve Bottega, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists [J]. J Biol, 2002, 1(2):10.

[29] Heiko Wurdak, Zhu Shou-tian, Kyung Hoon Min, et al. A small molecule accelerates neuronal differentiation in the adult rat [J]. Proc Natl Acad Sci, 2010, 107(38):16542–16547.

[30] Jonathan P Saxe, Wu Hao, Theresa K Kelly, et al. A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation [J].Chem Biol, 2007, 14(9):1019–1030.

[31] Canudas A M, Di Giorgi-Gerevini V, Iacovelli L, et al. PHCCC, a specific enhancer of type 4 metabotropic glutamate receptors, reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors [J]. J Neurosci, 2004, 24(46):10343–10352.

[32] Cheng Lin, Gao Long-fei, Guan Wu-qiang, et al. Direct conversion of astrocytes into neuronal cells by drug cocktail [J]. Cell Research, 2015, 25(11): 1269

[33] Zhang Lei, Yin Jiu-chao, Hana Yeh, et al. Small molecules efficiently reprogram human astroglial cells into functional neurons [J].Cell Stem Cell, 2015, 17(6): 735-747.

[34] Gao Long-fei, Guan Wu-qiang, Wang Min, et al. Direct generation of human neuronal cells from adult astrocytes by small molecules [J]. Stem Cell Reports, 2017, 8(3): 538-547

[35] Carlos P Fitzsimons, Emma van Bodegraven, Marijn Schouten, et al. Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease [J]. Molecular Neurodegeneration, 2014, 9(1): 25

[36] Shen Si-ming, Li Jia-dong, Patrizia Casaccia-Bonnefil. Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain [J]. J Cell Biol, 2005, 169(4):577–589

[37] Zhang Ling, Li Peng, Tiffany Hsu, et al. Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression [J]. Differentiation, 2011, 81(4): 233-242

[38] Philippe Taupin. Neurogenic drugs and compounds [J]. Recent Pat CNS Drug Discov, 2010, 5(3):253-257.

[39] Ma Jing, Gao Yuan, Jiang Lin, et al. Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice[J]. Oncotarget, 2017, 8(17): 27676.

[40] Mowla A, Mosavinasab M, Pani A. Does fluxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial [J]. J Clin Psychopharmacol, 2007, 27(1):67-70.

[41] Juan Sanchez-Ramos, Cynthia R Cimino, Ross Avila, et al. Pilot study of granulocyte-colony stimulating factor for treatment of Alzheimer’s disease [J]. J Alzheimers Dis, 2012, 31(4):843-855.

[42] Keith Wollen. Alzheimer’s disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners [J]. Altern Med Rev, 2010, 15(3):223-244.

[43] Robert J Williams, Jeremy PE Spencer. Flavonoids, cognition, and dementia: actions, mechanisms and potential therapeutics utility for Alzheimer’s disease [J]. Free Radic Biol, 2012, 52(1):35-45.

[44] Ren Zhi-li, Zuo Ping-ping. Neural regeneration: role of traditional Chinese medicine in neurological diseases treatment [J]. J Pharmacol Sci, 2012, 120(3):139-145.

[45] Florian T Merkle, Zaman Mirzadeh, Arturo Alvarez-Buylla. Mosaic organization of neural stem cells in the adult brain [J]. Science, 2007, 317(5836): 381–384.

[46] Alvarez-Buylla A, Daniel A Lim. For the long run: maintaining germinal niches in the adult brain [J]. Neuron, 2004, 41(5):683–686.

[47] Zhao Chun-mei, Deng Wei, Fred H Gage. Mechanisms and functional implications of adult neurogenesis [J]. Cell, 2008, 132(4): 645–660.

[48] Juan I Castrillo, Stephen G Oliver. Alzheimer’s as a systems-level disease involving the interplay of multiple cellular networks [J]. Systems Biology of Alzheimer's Disease, 2016: 3-48.

[49] Lyssiotis C A, Lairson L L, Boitano A E, et al. Chemical control of stem cell fate and developmental potential [J]. Angew Chem Int Ed Engl, 2011, 50(1):200–242.

[50] Andras J Bauer, Brent Stockwell. Neurobiological applications of small molecule screening [J]. Chem. Rev, 2008, 108(5):1774–1786.