New Ideas of Astragalus Combined with Bone Marrow Mesenchymal Stem Cells in the Treatment of Alzheimer’s Disease

doi:10.3969/j.issn.2095-1396.2016.02.006

Abstract

Abstract: Alzheimer’s disease （AD） is a primary central nervous system degenerative disease characterized by progressive cognitive impairment and memory impairment. With the aging of the population deepening，serious affection on the quality of life of the elderly AD has been social concern. The current treatment is mainly for drug，but it is only limited to control symptoms and delay the disease. The successful application of cell replacement therapy in clinical makes the research of cell transplantation become a hot spot. Bone marrow mesenchymal stem cells （BMSCs） have the potential of multi-directional differentiation and can be induced to differentiate into neurons in vitro. The use of BMSCs for the treatment of AD has provided new ideas and methods for the treatment of neurodegenerative diseases. Astragalus is one of the traditional Chinese medicine，which commonly used in clinical practice，recent research shows that astragalus is effective for the treatment of AD，and Astragalus can induce BMSCs to differentiate into neurons in vitro，and the treatment of AD by BMSCs induced by Astragalus in vivo has not been reported at home and abroad. In this paper，a systematic review of the research status on the treatment of AD by Astragalus combined with BMSCs，BMSCs treatment of AD and Astragalus treatment of AD will be presented.

Key words: Alzheimer&, rsquo, s disease, bone marrow mesenchymal stem cells, cell transplantation, astragalus, induced differentiation

CLC Number:

R964

LI Peng-tao, YANG Xiao-nan, HUO Yan-li, ZHANG Hui. New Ideas of Astragalus Combined with Bone Marrow Mesenchymal Stem Cells in the Treatment of Alzheimer’s Disease[J]. ACTA NEUROPHARMACOLOGICA, 2016, 6(2): 31-36.

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