蛋白质组学在帕金森病研究中的应用研究进展

神经药理学报 ›› 2015, Vol. 5 ›› Issue (3): 28-35.

蛋白质组学在帕金森病研究中的应用研究进展

郝军荣，沈丽霞

河北北方学院药学系，张家口，075000，中国

出版日期:2015-06-26 发布日期:2015-07-06
通讯作者: 沈丽霞，女，教授；研究方向：神经药理学；Tel：+86-0313-4029423，E-mail：shenlixiacn@163.com
作者简介:郝军荣，女，讲师；研究方向：神经药理学及相关药物；Tel：+86-0313-4029305，E-mail：haojunrong3@163.com
基金资助:
河北北方学院自然科学青年基金项目（No.Q2014030）、河北省自然科学基金项目（No.H2012405016）、河北北方学院创新人才培育基金项目（No.CXRC1325），2013年度河北北方学院校级重大项目（No.ZD201310）

The Research Progress of Proteomics Used in Parkinson’s Disease

HAO Jun-rong，SHEN Li-xia

Department of Pharmacy，Hebei North University，Zhangjiakou，075000，China

Online:2015-06-26 Published:2015-07-06
Contact: 沈丽霞，女，教授；研究方向：神经药理学；Tel：+86-0313-4029423，E-mail：shenlixiacn@163.com
About author:郝军荣，女，讲师；研究方向：神经药理学及相关药物；Tel：+86-0313-4029305，E-mail：haojunrong3@163.com
Supported by:
河北北方学院自然科学青年基金项目（No.Q2014030）、河北省自然科学基金项目（No.H2012405016）、河北北方学院创新人才培育基金项目（No.CXRC1325），2013年度河北北方学院校级重大项目（No.ZD201310）

摘要/Abstract

摘要： 帕金森病（Parkinson’s disease，PD）是与年龄相关的神经系统慢性退行性疾病，主要病理特征为黑质多巴胺能神经元持续变性，其病因和发病机理尚不清楚。蛋白质组学是从整体水平研究蛋白质在不同疾病状态或外界因素作用下的差异表达情况，已成为探索疾病发病机制、疾病诊断和药物治疗最有效的方法，并为PD发病机制的研究、发现PD的诊断标记物和寻找药物治疗新靶点及研制可靠药物提供有力的依据。本文就蛋白质组学在PD研究中对PD细胞和动物模型、发病机制和PD的诊断以及药物治疗研究中的应用进展做一综述。

关键词: 蛋白质组学, 帕金森病, 神经退行性疾病

Abstract: Parkinson’s disease （PD） is an age-related，neurodegenerative disease characterized by progressive degeneration of dopaminergic neurons in the substantia nigra. The etiology and pathogenesis are still unknown. Proteomics is used to study the expressions of the proteins in the overall level in different states of disease or under the external factor. It offers the powerful basis for the pathogenesis of PD，discovering the markers for diagnosis of PD searching
new spot and reliable drugs. In this paper，we review the progress in application of proteomics in PD animal and cell models，pathogenesis，diagnosis and drug treatment of PD.

Key words: proteomics, Parkinson&, rsquo, s disease, neurodegenerative disease

中图分类号:

R742.5

郝军荣，沈丽霞. 蛋白质组学在帕金森病研究中的应用研究进展[J]. 神经药理学报, 2015, 5(3): 28-35.

HAO Jun-rong，SHEN Li-xia. The Research Progress of Proteomics Used in Parkinson’s Disease[J]. Acta Neuropharmacologica, 2015, 5(3): 28-35.

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