ATP 敏感钾通道在神经退行性疾病中的研究进展

doi:10.3969/j.issn.2095-1396.2017.05.009

摘要/Abstract

摘要：

ATP 敏感钾通道（ATP-sensitive potassium channel，KATP），因其通道活性受ATP/ADP 的影响而得名。KATP 是一种耦联细胞电活动和细胞代谢的特殊通道，通道功能在正常状态下，对于维持神经细胞线粒体膜电位、抑制细胞凋亡有重要作用。KATP 广泛存在于胰岛细胞、心肌、骨骼肌、血管平滑肌和神经细胞等组织中。近几年的研究发现KATP 参与了多种疾病的发病过程，该文对ATP 敏感钾通道在神经退行性疾病中的研究进展作了综述。

关键词: ATP 敏感钾通道, 神经退行性疾病, 研究进展

Abstract:

The ATP-sensitive potassium channel （KATP） is named because its channel activity is affected by ATP/ADP. KATP is a special channel that couples cell electrical activity and cell metabolism. Under normal conditions，channel function plays an important role in maintaining mitochondrial membrane potential and inhibiting cell apoptosis. KATP is widely found in islets，myocardium，skeletal muscle，vascular smooth muscle，and nerve cells. In recent years，studies have found that KATP is involved in the pathogenesis of a variety of diseases. This article reviews the research progress of ATP-sensitive potassium channels in neurodegenerative diseases.

Key words: ATP-sensitive potassium channels, neurodegenerative diseases, research progress

中图分类号:

R329.25

引用本文

边芳，侯艳宁. ATP 敏感钾通道在神经退行性疾病中的研究进展[J]. 神经药理学报, DOI: 10.3969/j.issn.2095-1396.2017.05.009.

BIAN Fang1，HOU Yan-ning2. Research Progress of the ATP Sensitive Potassium Channels in Neurodegenerative Diseases[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2017.05.009.

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参考文献

1 Noma A. ATP-regulated K⁺ channels in cardiac muscle[J]. Nature, 1983, 305(5930):147-148.

2 Stephan D, Winkler M, Kühner P, et al. Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP) channels[J]. Diabetologia, 2006, 49(9):2039.

3 Li Ning-ning, Wu Jing-xiang, Ding Dian, et al. Structure of a pancreatic ATP-sensitive potassium channel[J]. Cell, 2017, 168(1-2):101.

4 Sofija Jovanovic, Thomas Ballantyne, Du Qing-you, et al. Phenylephrine preconditioning in embryonic heart H9c2 cells is mediated by up-regulation of SUR2B/Kir6.2: A first evidence for functional role of SUR2B in sarcolemmal KATP channels and cardioprotection[J]. Int J Biochem Cell Biol, 2016, 70:23-28.

5 Thomas M Bodenstine, Kedar S Vaidya, Aimen Ismail, et al. Subsets of ATP‐sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression[J]. Febs Letters, 2012, 586(1):27-31.

6 郭建, 陆晓晔, 杨倩, 等. ATP敏感的钾通道相关研究进展[J]. 临床急诊杂志, 2018, (1).

7 Timothy M Olson, Andre Terzic. Human K(ATP) channelopathies: diseases of metabolic homeostasis[J]. Pflügers Archiv: European J Physiology, 2010, 460(2):295-306.

8 Cole W C, Mcpherson C D, Sontag D. ATP-regulated K⁺ channels protect the myocardium against ischemia/reperfusion damage[J]. Circulation Research, 1991, 69(3):571-81.

9 Juliana N Carreiro, Marciane Magnani, Phillip Jobling, et al. Resveratrol restores uterine contractions during hypoxia by blockade of ATP-sensitive potassium channels[J]. J Functional Foods, 2017, 33:307-313.

10 张登文, 张传汉, 王学仁. 心血管系统ATP敏感性钾离子通道的结构和功能[J]. 华中科技大学学报: 医学版, 2014(4):482-485.

11 杨宝峰. 离子通道药理学[M]. 人民卫生出版社, 2005.

12 杜希恂, 秦康, 焦倩,等. ATP敏感性钾通道与帕金森病关系的研究进展[C]// 庆祝中国生理学会成立90周年专辑. 2016.

13 Francesco Occhiuto, Giuseppe Zangla, Stefania Samperi, et al. The phytoestrogenic isoflavones from Trifolium pratense L. (Red clover) protects human cortical neurons from glutamatetoxicity [J]. Phytomedicine, 2008,15(9): 676-682.

14 Roos J Jutten, John Harrison, Frank Jan de Jong, et al. A composite measure of cognitive and functional progression in Alzheimer's disease: Design of the Capturing Changes in Cognition study[J]. Alzheimers & Dementia Translational Research & Clinical Interventions, 2017, 3(1):130-138.

15 Linda Helmfors, Andrea Boman, Livia Civitelli, et al. Protective properties of lysozyme onβ-amyloid pathology: implications for Alzheimer disease[J]. Neurobiology of Disease, 2015, 83:122-133.

16 Ricardo B Maccioni, Juan P Muñoz, Luis Barbeito. The molecular bases of Alzheimer's disease and other neurodegenerative disorders[J]. Archives of Medical Research, 1900, 32(5):367-381.

17 Inelia Morales, Gonzalo Farías, Ricardo Maccioni. Neuroimmunomodulation in the pathogenesis of Alzheimer's disease[J]. Neuroimmunomodulation, 2010, 17(3):202-204.

18 Reisa A Sperling, Paul S Aisen, Laurel A Beckett, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guide lines for Alzheimer's disease[J]. Alzheimers Dement, 2011, 7(3): 280-292.

19 Marilyn S Albert, Steven T DeKosky, Dennis Dickson, et al. The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers Dement, 2011, 7(3): 270-279.

20 Guy M McKhann, David S Knopman, Howard Chertkow, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association work groups on diagnostic guidelines for Alzheimer's disease[J]. Alzheimers Dement, 2011, 7(3) 263-269.

21 Grutzendler J, Morris J C. Cholinesterase inhibitors or Alzheimer's disease[J]. Drugs, 2002, 360(9342):1332-1333.

22 Mohammad Hossein Esmaeili, Behnam Bahari, Ali-Akbar Salari. ATP-sensitive potassium-channel inhibitor glibenclamide attenuates HPA axis hyperactivity, depression-and anxiety-related symptoms in a rat model of Alzheimer's disease[J].Brain Research Bulletin, 2018,137(3): 265-276.

23 李艳菊, 谭淑慧, 夏春凤,等. NF-κB对Aβ1-42诱导神经元K_ATP亚基Kir6.2/SUR1表达的影响[J]. 山东大学学报:医学版, 2013, 51(10):5-9.

24 Chelsea Griffith, Xie Mi-xin, Qiu Wen-ying, et al. Aberrant expression of the pore-forming KATP channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer's disease[J]. Neuroscience, 2016, 336:81-101.

25 Moriguchi S, Ishizuka T, Yasushi Yabuki, et al. Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer's disease therapy[J]. Molecular Psychiatry, 2016, 23(2):187..

26 Chen Hong-zhi, He Jian-cheng, Teng Long, et al.Traditional Chinese Medicine symptom pattern analysis for Parkinson’s disease[J]. 中医杂志:英文版, 2017, 37(5): 688-694

27 Karin Wirdefeldt, Hans-Olov Adami, Philip Cole, et al. Epidemiology and etiology of Parkinson’s disease: a review of the evidence[J]. European J Epidemiology, 2011, 26(1):1.

28 Fabio Henrique de Amorim Aroxa, Ihana Thais Guerra de Oliveira Gondim, Elba Lucia Wanderley Santos, et al. Acupuncture as adjuvant therapy for sleep disorders in parkinson's disease[J]. J Acupuncture & Meridian Studies, 2017, 10(1):33.

29 Taylor K S, Cook J A, Counsell C E. Heterogeneity in male to female risk for Parkinson's disease[J]. J Neurology Neurosurgery & Psychiatry, 2007, 78(8):905-906.

30 刘疏影, 陈彪. 帕金森病流行现状[J]. 中国现代神经疾病杂志, 2016, 16(2):98-101.

31 Lee J Martin. Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis[J]. J Neuropathology & Experimental Neurology, 2006, 65(12):1103-10.

32 C Savio Chan, Jaime N Guzman, Ema Ilijic, et al. 'Rejuvenation' protects neurons in mouse models of Parkinson's disease[J]. Nature, 2007, 447(7148):1081-1086.

33 Julia Schiemann, Falk Schlaudraff, Verena Klose, et al. K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration[J]. Nature Neuroscience, 2012, 15(9):1272-1280.

34 Evangelia Emmanouilidou, Georgia Minakaki, Maria V Keramioti, et al. GABA transmission via ATP-dependent K⁺ channels regulates α-synuclein secretion in mouse striatum[J]. Brain A J Neurology, 2016, 139(Pt 3):871.

35 Francisco J Ortega, Jukka Jolkkonen, Nicole Mahy, et al. Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia[J]. J Cerebral Blood Flow & Metabolism Official J Int Society of Cerebral Blood Flow & Metabolism, 2013, 33(3):356-64.

36 Masaki Nakano, Hiromi Imamura, Norio Sasaoka, et al. ATP maintenance via two types of ATP regulators mitigates pathological phenotypes in mouse models of Parkinson's disease[J]. Ebiomedicine, 2017, 22(C):225-241.

37 Damien Toulorge, Serge Guerreiro, Etienne C Hirsch, et al. KATP channel blockade protects midbrain dopamine neurons by repressing a glia-to-neuron signaling cascade that ultimately disrupts mitochondrial calcium homeostasis[J]. J Neurochemistry, 2010, 114(2):553-564.

38 Peng Kai-ge, Hu Jun, Xiao Jing-song, et al. Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson's disease[J]. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018, 1864(4 Pt A):1086-1103.

39 Polin Haghverdizadeh, Monir Sadat Haerian, Pantea Haghverdizadeh, et al. ABCC8 genetic variants and risk of diabetes mellitus[J]. Gene, 2014, 545(2):198-204.

40 Wu Han, Yang Sheng-qi, Huang Zhang-qin, et al.Type 2 diabetes mellitus prediction model based on data mining[J]. J Informatics in medicine, 10(2018) 100-107.

41 Abdulellah Alotaibi, Lin Perry, Leila Gholizadeh, et al. Incidence and prevalence rates of diabetes mellitus in Saudi Arabia: An overview[J]. J Epidemiology & Global Health, 2017, 7(4):211-218.

42 Quan Yi, Andrew Barszczyk, Feng Zhong-ping, et al. Current understanding of KATP channels in neonatal diseases: focus on insulin secretion disorders[J]. 中国药理学报, 2011, 32(6):765-780.

43 Koster J C, Marshall B A, Ensor N, et al. Targeted overactivity of β cell KATP channels induces profound neonatal diabetes[J]. Cell, 2000, 100(6):645-654.

44 Seino S, Iwanaga T, Nagashima K, et al. Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice[J]. Diabetes, 2000, 49(3):311-318.

45 Victor Seghers, Mitsuhiro Nakazaki, Franco DeMayo, et al. Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion[J]. J Biological Chemistry, 2000, 275(13):9270.

46 Chen Hao, Zhang Ruo-qing, Wei Xiao-gang, et al. Mechanism of TLR-4/NF-κB pathway in myocardial ischemia reperfusion injury of mouse[J]. Asian Pacific J Tropical Medicine, 2016, 9(5):503.

47 Yang Yong, Jia Hong-mei, Yu Meng, et al. Chinese patent medicine Xin-Ke-Shu inhibits Ca²⁺ overload and dysfunction of fatty acid β-oxidation in rats with myocardial infarction induced by LAD ligation[J]. J Chromatography B, 2018, 1079:85-94.

48 Shay P McGuinness, Rachael L Parke, Kate Drummond, et al. A multicenter, randomized, controlled phase IIb trial of avoidance of hyperoxemia during cardiopulmonary bypass[J]. Anesthesiology, 2016, 61(2):27.

49 Hai Xia Zhang, Jonathan R Silva, Lin Yu-Wen, et al. Heterogeneity and function of K(ATP) channels in canine hearts[J]. Heart Rhythm the Official J Heart Rhythm Society, 2013, 10(10):1576-1583.

50 Amir Toib, Zhang Hai-xia, Thomas J Broekelmann, et al. Cardiac specific ATP-sensitive K⁺ channel (KATP) overexpression results in embryonic lethality[J]. J Molecular & Cellular Cardiology, 2012, 53(3):437-445.

51 Andrew Tinker, Qadeer Aziz, Alison Thomas. The role of ATP-seensitive potassium channels in cellular function and protaction in the cardivascular system[J]. Br J Pharmacol, 2014, 171(1):12-23.

52 马晓丽, 冷玉芳, 杨珮宁,等. ATP敏感性钾通道在羟考酮后处理减轻大鼠心肌缺血再灌注损伤中的作用[J]. 中华麻醉学杂志, 2016, 36(8):955-957.

53 Cristian Romeo Revnic, Carmen Ginghina, Adriana Sarah Nica, et al. Studies of ischemic preconditioning mechanisms in langendorff rat heart model the impact of phosphocreatin kinase and ATP sensitive potasium channels pharmachological openers and blockers on cardioprotection[J]. Agriculture & Agricultural Science Procedia, 2016, 10:299-310.

54 Feng Ying, Liu Jian-fang, Wang Meng-long, et al. The E23K variant of the Kir6.2 subunit of the ATP-sensitive potassium channel increases susceptibility to ventricular arrhythmia in response to ischemia in rats[J]. Int J Cardiology, 2017, 232:192-198.

55 Özden Vezir, Ülku Çömeleko?lu, Nehir Sucu, et al. N-Acetylcysteine-induced vasodilatation is modulated by KATP channels, Na(+)/K(+)-ATPase activity and intracellular calcium concentration: An in vitro study[J]. Pharmacological Reports, 2017, 69(4):738-745.

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