血脑屏障体外模型的研究进展

doi:10.3969/j.issn.2095-1396.2016.01.004

神经药理学报 ›› 2016, Vol. 6 ›› Issue (1): 25-34.DOI: 10.3969/j.issn.2095-1396.2016.01.004

血脑屏障体外模型的研究进展

秦雪晴，杨志宏，孙晓波

1. 哈尔滨商业大学，哈尔滨，150076，中国
2. 中国医学科学院药用植物研究所，北京，100193，中国

出版日期:2016-02-26 发布日期:2016-05-10
通讯作者: 杨志宏，女，博士，副研究员，硕士生导师；研究方向：药物代谢动力学及中药复方配伍机制；Tel：+86-010-57833219，E-mail： zhyang@implad.ac.cn
作者简介:秦雪晴，女，硕士研究生；研究方向：药理学；E-mail：qxq920309@163.com
基金资助:
国家自然科学基金项目（No.81273654，No.81473579，No.81102879），国家重大新药创制项目（No.2013ZX09103002-022）

A Review of Studies on Blood Brain Barrier in vitro Model

QIN Xue-qing，YANG Zhi-hong，SUN Xiao-bo

1. Harbin University of Commerce，Harbin，150076，China
2. Institute of Medicinal Plant，Chinese Academy of Medical Sciences，Beijing，100193，China

Online:2016-02-26 Published:2016-05-10
Contact: 杨志宏，女，博士，副研究员，硕士生导师；研究方向：药物代谢动力学及中药复方配伍机制；Tel：+86-010-57833219，E-mail： zhyang@implad.ac.cn
About author:秦雪晴，女，硕士研究生；研究方向：药理学；E-mail：qxq920309@163.com
Supported by:
国家自然科学基金项目（No.81273654，No.81473579，No.81102879），国家重大新药创制项目（No.2013ZX09103002-022）

摘要/Abstract

摘要： 血脑屏障是由脑微血管内皮细胞、星形胶质细胞和周皮细胞等组成的动态生理结构，在维持中枢系统内环境稳态中发挥着重要作用。体外实验其高效、灵敏、快速、稳定等特点使其成为候选药物高通量筛选及生理病理机制研究的首选方案。该文主要对体外血脑屏障模型的种类、组成及应用进行评述，结合国内外文献报道，记述了经典模型的同时，详细描述了大量国内外的最新模型及先进技术，为中枢神经系统药物筛选及体外血脑屏障机制研究提供参考。

关键词: 血脑屏障, 体外模型, 研究进展

Abstract: Blood brain barrier（BBB） is a dynamic physiological structure，which is composed of brain microvascular endothelial cells，astrocytes and pericytes，playing an important role in maintaining homeostasis in the central nervous system. In vitro experiment is the preferred alternative to the study of early central nervous system drugs screening，pathological and physiological mechanism because of high-throughput，efficient，sensitive，rapid，and accurate characteristics. This paper focuses on the types，compositions and application of in vitro models of BBB，reviews the domestic and foreign literatures，describes the classical models and introduces the latest advanced technology，provides a reference for central nervous system drugs screening and in vitro BBB mechanism research.

Key words: blood brain barrier（ BBB）, in vitro model, research progress

中图分类号:

R965.1

秦雪晴，杨志宏，孙晓波. 血脑屏障体外模型的研究进展[J]. 神经药理学报, 2016, 6(1): 25-34.

QIN Xue-qing，YANG Zhi-hong，SUN Xiao-bo. A Review of Studies on Blood Brain Barrier in vitro Model[J]. Acta Neuropharmacologica, 2016, 6(1): 25-34.

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血脑屏障体外模型的研究进展

A Review of Studies on Blood Brain Barrier in vitro Model

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