乔松素临床应用和作用机制的研究进展

doi:10.3969/j.issn.2095-1396.2016.05.007

摘要/Abstract

摘要： 乔松素是一种天然的黄酮类化合物，在蜂胶、姜科植物、牛至属植物等植物中有较高的含量。在临床前期研究中，乔松素表现出良好的抗炎、抗肿瘤、抗氧化、降低血脂和神经保护作用等。近年来国内外对乔松素神经保护方面的研究发现，其可以通过减少活性氧产生、保护血脑屏障完整性、调节线粒体功能和调控细胞凋亡等发挥作用。该文对乔松素的药物代谢动力学和潜在的治疗应用及其作用机制等方面进行综述，为乔松素的后续研究提供参考。

关键词: 乔松素, 药物代谢动力学, 治疗应用, 作用机制, 研究进展

Abstract: Pinocembrin is a natural flavonoid compound extracted from propolis，ginger plants，wild marjoram，and other plants which have a higher content. In the preclinical studies，it has shown anti-inflammatory，anti-tumor，antioxidant，decrease blood lipids，neuroprotective effects and other pharmacological effects. In recent domestic and foreign studies focused on pinocembrin neuroprotective effects as well as the ability to attenuate reactive oxygen species，protect the blood-brain barrier，modulate mitochondrial function，and regulate apoptosis. Pinocembrin is a potential drug to treat ischemic stroke and other clinical conditions. In this review，we summarize its pharmacokinetics，mechanisms of action and potential therapeutic applications，in order to provide a reference for pinocembrin mechanisms research and therapeutic applications.

Key words: pinocembrin, pharmacokinetics, therapeutic applications, mechanisms of action, research progress

张海威，张力. 乔松素临床应用和作用机制的研究进展[J]. 神经药理学报, 2016, 6(5): 45-52.

Zhang Hai-wei，Zhang Li. Research Progress on Pinocembrin：Potential Therapeutic Applications and Action Mechanisms[J]. Acta Neuropharmacologica, 2016, 6(5): 45-52.

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