P- 糖蛋白在神经元中的表达及氧化应激对P- 糖蛋白的影响

doi:10.3969/j.issn.2095-1396.2018.03.002

摘要/Abstract

摘要：

P- 糖蛋白（P-glycoprotein，P-gp）由多药耐药（ multidrug resistance，MDR）基因编码，是三磷酸腺苷（adenosine triphosphate，ATP）结合盒转运蛋白家族的成员之一。作为血脑屏障（blood brain barrier，BBB）的重要组成部分，P-gp 是一种能量依赖性转运蛋白，可以阻止外源性物质进入细胞，还可以将体内有害的毒性物质排出，是机体的保护屏障。神经元是构成神经系统结构和功能的基本单位，癫痫、脑缺血及神经退行性疾病等许多神经系统疾病最明显的病理变化就是神经元细胞的损伤与凋亡。许多研究和报道显示，在一些脑部病理状态下，P-gp 在内皮细胞上的表达会有所改变，但是在神经元细胞上P-gp 的变化研究较少。由于氧化应激是许多疾病发生和发展的关键因素之一，该文主要对病理状态下神经元细胞上P-gp 的表达的及氧化应激对P-gp 的影响做一综述。

关键词: P- 糖蛋白, 神经元, 氧化应激, 癫痫, 脑缺血, 神经退行性疾病

Abstract:

P-glycoprotein （P-gp），which is encoded by a multidrug resistance （MDR）gene，is a member of the ATP-binding cassette transporter family. As an important part of the blood-brain barrier （BBB），P-gp is an energy-dependent transporter that blocks the entry of exogenous substances into the cell，and it can also excrete harmful toxic substances in the body. It is a protective barrier of the body. Neurons are the basic units that make up the structure and function of the nervous system. The most obvious pathological changes in many neurological diseases like epilepsy，cerebral ischemia，and neurodegenerative diseases，etc. are the neuronal cells’ injury and apoptosis. Many studies have shown that in some disease states，the expression of P-gp will change，but most of the studies are focused on endothelial cells，and the study of changes in P-gp on neurons is much less. Since oxidative stress is one of the key factors in the occurrence and development of many neurological diseases. This review focuses on the expression of P-gp on neurons and the effect of oxidative stress on P-gp in pathological states.

Key words: P-glycoprotein, neurons, oxidative stress, epilepsy, cerebral ischemia, neurodegenerative disease

中图分类号:

R971

白如冰，张忠泉，岑娟. P- 糖蛋白在神经元中的表达及氧化应激对P- 糖蛋白的影响[J]. 神经药理学报, DOI: 10.3969/j.issn.2095-1396.2018.03.002.

BAI Ru-bing，ZHANG Zhong-quan，CEN Juan. The Expression of P-Glycoprotein in Neurons and the Effect of Oxidative Stress on P-Glycoprotein[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2018.03.002.

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