基底前脑胆碱能神经元功能异常在阿尔茨海默病中的作用相关研究进展

doi:10.3969/j.issn.2095-1396.2017.04.008

摘要/Abstract

摘要： 细胞外老年斑的沉积和细胞内神经纤维缠结被认为是阿尔茨海默病（Alzheimer’s disease，AD）典型的病理改变。基底前脑胆碱能神经元（basal forebrain cholinergic neurons，BFCNs）功能异常导致的海马乙酰胆碱（acetylcholine，ACh）功能下降也被认为是AD 发生的主要特征。该文介绍了ACh 突触传递过程、BFCNs 投射系统、BFCNs 在调节认知功能中的作用以及BFCNs 功能异常在AD 中的作用和近期的研究进展。

关键词: 阿尔茨海默病, 基底前脑, 胆碱能神经元, 乙酰胆碱

Abstract: Excellular senile plaques deposits and intracelllar neurofibrillary tangles are the typical neuropathologies of Alzheimer’s disease （AD）. AD is also characterized by cholinergic hypofunction in hippocampus caused by basal forebrain cholinergic neurons（ BFCNs） dysfunction. This review focues on ACh neurotransmission，BFCNs projective system，the regulatory roles of BFCNs in cognition and the progression of BFCNs dysfunction in AD.

Key words: Alzheimer&, rsquo, s disease, basal forebrain, cholinergic neurons, acetylcholine

中图分类号:

R338，R741.02

田由，王雪，艾静. 基底前脑胆碱能神经元功能异常在阿尔茨海默病中的作用相关研究进展[J]. 神经药理学报, 2017, 7(4): 53-64.

TIAN You，WANG Xue，AI Jing. Research Progress of Basal Forebrain Cholinergic Dysfunction in Alzheimer’s Disease[J]. Acta Neuropharmacologica, 2017, 7(4): 53-64.

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