脑源雌激素在阿尔茨海默病中的作用研究进展

doi:10.3969/j.issn.2095-1396.2019.05.010

摘要/Abstract

摘要： 流行病学研究表明，绝经后女性阿尔茨海默病（Alzheimer’s disease，AD）的患病风险远高于男性。大量临床实验研究表明，女性绝经后脑源雌激素水平的下降与阿尔茨海默病的患病风险有关。该文介绍了近年来关于体内雌激素（尤其脑源雌激素）合成及代谢过程和作用机制、脑雌激素受体（estrogen receptors，ERs）、脑源雌激素在调节认知功能中的作用以及脑源雌激素功能异常在 AD 中的作用的研究进展。

关键词: 阿尔茨海默病, 脑源雌激素, 雌激素受体

Abstract:

Epidemiological studies have shown that the risk of Alzheimer’s disease （AD）in postmenopausal women is much higher than that in men. Numerous clinical trials have indicated that decreased level of brain-derived estrogen in women is related to the risk of AD. This review focuses on the synthesis，metabolism and action mechanisms of estrogen（especially brain-derived estrogen），the role of brain estrogen receptors（ERs），brain-derived estrogen in the regulation of cognitive function and brain-derived estrogen dysfunction in the progression of AD.

Key words: Alzheimer’s disease, brain-derived estrogen, estrogen receptors

中图分类号:

R964

杨琳，艾静. 脑源雌激素在阿尔茨海默病中的作用研究进展[J]. 神经药理学报, DOI: 10.3969/j.issn.2095-1396.2019.05.010.

YANG-Lin，AI-Jing. Research Progress of Brain-Derived Estrogen in Alzheimer’s Disease[J]. Acta Neuropharmacologica, DOI: 10.3969/j.issn.2095-1396.2019.05.010.

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