神经药理学报 ›› 2023, Vol. 13 ›› Issue (6): 50-.DOI: 10.3969/j.issn.2095-1396.2023.06.010

• 综述 • 上一篇    下一篇

普罗布考在保护神经系统中的研究现状

朱静怡,樊建春,禹爱梅   

  1. 1. 河北北方学院研究生学院,张家口,075000,中国 

    2. 河北北方学院附属第一医院神经内科,张家口,07500,中国

  • 出版日期:2023-12-26 发布日期:2024-05-08
  • 通讯作者: 禹爱梅,主任医师,硕士生导师;研究方向:脑血管病与认知障碍相关研究
  • 作者简介:朱静怡,河北北方学院2021级研究生;研究方向:脑血管病与认知障碍相关研究;E-mail:zhujingyi997@163.com

Research Status on the Neuroprotective Effect of Probucol

ZHU Jing-yi ,FAN Jian-chun,YU Ai-mei   

  1. 1. Hebei North University, Zhangjiakou, 075000, China 

    2 Department of Neurology, the First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China

  • Online:2023-12-26 Published:2024-05-08
  • Contact: 禹爱梅,主任医师,硕士生导师;研究方向:脑血管病与认知障碍相关研究
  • About author:朱静怡,河北北方学院2021级研究生;研究方向:脑血管病与认知障碍相关研究;E-mail:zhujingyi997@163.com

摘要:

普罗布考(probucol, Prob)存在两个易被氧化的酚羟基,能够与氧自由基结合形成稳定的酚氧集团,具 有强大的降脂、抗炎和抗氧化等多种功能,在心脑血管疾病的预防和治疗中起关键作用。该文根据近年来国内外 研究报道,综述普罗布考在中枢神经系统和周围神经系统中的保护作用及其详细保护机制。

关键词: 普罗布考, 神经保护作用, 缺血性脑卒中, 阿尔茨海默病, 帕金森病

Abstract:

Probucol has two easily oxidized phenolic hydroxyl groups, which can combine with oxygen free radicals to form a stable phenolic oxygen group. It has powerful lipid-lowering, anti-inflammatory and antioxidant functions and plays an important role in the treatment process. This article reviews the protective effects and detailed protective mechanisms of probucol in the central nervous system and peripheral nervous system based on domestic and foreign literature in recent years.

Key words: probucol, neuroprotection, ischemic stroke, Alzheimer's disease, Parkinson's disease