蛇床子素对脑缺血损伤的保护作用机制研究进展

神经药理学报 ›› 2012, Vol. 2 ›› Issue (2): 42-47.

蛇床子素对脑缺血损伤的保护作用机制研究进展

张玮^1,2 ，韩宁¹ ，胡金凤¹ ，陈乃宏¹

1天然药物活性物质与功能国家重点实验室，新药作用机制研究与药效评价北京市重点实验室,中国医学科学院药物研究所，北京，100050，中国 2. 天津中医药大学，天津，300193，中国

出版日期:2012-04-26 发布日期:2013-11-01
通讯作者: 陈乃宏，男，博士，研究员；研究方向：神经药理；Tel：+86-010-63165177, E-mail： chennh@imm.ac.cn
作者简介:张玮，女，硕士研究生；研究方向：脑血管药理；E-mail： luxixi1987@126.com
基金资助:
国家国际科技合作项目（No.2010DFB32900），国家自然科学基金(No.81173578、No.81274122)，国家“重大新药创制”科技重大专项（No.2012ZX09103101-006、No.2012ZX09301002-004），教育部创新团队（No.IRT1007），北京市自然基金（No.7131013）

Reseach Progress in the Mechanism of Osthole in Protecting Brain Ischemia

ZHANG Wei^1,2, HAN Ning¹, HU Jinfeng¹, CHEN Nai-hong¹

1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China 2. Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China

Online:2012-04-26 Published:2013-11-01
Contact: 陈乃宏，男，博士，研究员；研究方向：神经药理；Tel：+86-010-63165177, E-mail： chennh@imm.ac.cn
About author:张玮，女，硕士研究生；研究方向：脑血管药理；E-mail： luxixi1987@126.com
Supported by:
国家国际科技合作项目（No.2010DFB32900），国家自然科学基金(No.81173578、No.81274122)，国家“重大新药创制”科技重大专项（No.2012ZX09103101-006、No.2012ZX09301002-004），教育部创新团队（No.IRT1007），北京市自然基金（No.7131013）

摘要/Abstract

摘要： 对近年来有关蛇床子素脑缺血保护作用研究的文章进行总结，我们发现其不仅能抑制脑缺血再灌过程中的炎性反应、减轻脑水肿而保护受损脑组织，还能增加缺血脑组织中抗氧化酶的活性，清除氧自由基而减少再灌过程中自由基带来的损伤。此外蛇床子素还展现了良好的抗凝抗血栓作用，因此我们从抗炎、抗氧化、抗凝、抗凋亡等几个方面分析蛇床子素发挥保护作用的可能作用机制,以期为进一步研究蛇床子素防治脑缺血的药理作用提供参考。

关键词: 蛇床子素, 脑缺血, 炎症, 抗氧化, 抗凝

Abstract: In this paper, the publications of osthole in protecting brain ischemia were retrieved and summarized. Our analysis found that osthole not only can decrease the cerebral ischemia reperfusion injury by inhibiting the inflammation reaction and lowering cerebral edema, but also can increase the activity of antioxidant enzymes in the ischemic tissue of the brain, scavenge oxygen free radicals and reduce ischemia reperfusion injury caused by free radicals. Furthermore, osthole also exhibited a good anticoagulant effect. So the possible mechanisms of the protective role of osthole were reviewed from anti-inflammatory, anti-oxidation, anti- coagulantion, anti-apoptosis and other aspects, in order to provide support for the further pharmacological studies of osthole in brain cerebral ischemia.

Key words: osthole, cerebral ischemia, inflammation, anti-oxidation, anti-coagulantion

中图分类号:

R743

张玮，韩宁，胡金凤，陈乃宏. 蛇床子素对脑缺血损伤的保护作用机制研究进展[J]. 神经药理学报, 2012, 2(2): 42-47.

ZHANG Wei, HAN Ning, HU Jinfeng, CHEN Nai-hong. Reseach Progress in the Mechanism of Osthole in Protecting Brain Ischemia[J]. Acta Neuropharmacologica, 2012, 2(2): 42-47.

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