中枢肾素-血管紧张素系统与阿尔茨海默病

摘要/Abstract

摘要： 阿尔茨海默病（Alzheimer's disease，AD）是全球共同关注的重大公共卫生课题和日益严重的社会问题，发掘防治AD的新靶标和新药物是当今医药领域亟待破解的难题。越来越多的研究显示，中枢肾素-血管紧张素系统（central rennin-angiotensin system，CRAS）与AD密切相关。本文根据相关文献报道，综述CRAS中血管紧张素II（angiotensin II，Ang II）及其受体（angiotensin II type 1 receptor，AT₁R；angiotensin II type 2 receptor，AT₂R），血管紧张素IV（angiotensin IV，Ang IV）及其受体（angiotensin II type 4 receptor，AT₄R）以及血管紧张素转化酶（angiotensin converting enzyme，ACE）在AD发生发展中的作用，揭示可能成为防治AD的新靶标，提出开发新型抗AD药物的新思路。

关键词: 阿尔茨海默病, 血管紧张素1型受体, 血管紧张素2型受体, 血管紧张素4型受体, 血管紧张素转化酶

Abstract: Alzheimer's disease (AD) is not only a global major public health issue of common concern, but also an increasingly serious social problem. Developing novel prevention or treatment targets and drugs of AD is an arduous task that remains to be overcome. More and more studies show that central rennin-angiotensin system (CRAS) is closely associated with AD. Based on related literatures, we reviewed the roles of Ang II and its receptors (AT₁R and AT₂R), Ang Ⅳ and its receptor (AT₄R) as well as ACE in AD, and revealed potential targets, and indicated new directions to developing drugs for AD.

Key words: Alzheimer's disease (AD), angiotensin II type 1 receptor (AT₁R), angiotensin II type 2 receptor (AT₂R), angiotensin II type 4 receptor (AT₄R), angiotensin converting enzyme (ACE)

中图分类号:

R964

王超，项国卿，洪浩. 中枢肾素-血管紧张素系统与阿尔茨海默病[J]. 神经药理学报, 2012, 2(2): 37-41.

WANG Chao，XIANG Guo-qing，HONG Hao. Central Rennin-angiotensin System and Alzheimer's Disease[J]. Acta Neuropharmacologica, 2012, 2(2): 37-41.

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