神经药理学报

神经药理学报 ›› 2023, Vol. 13 ›› Issue (1): 49-.DOI: 10.3969/j.issn.2095-1396.2023.01.009

• 综述 • 上一篇    下一篇

中药治疗抑郁症的研究进展

牛聪，吴志刚   

  1. 河北北方学院药学系，张家口市中药防治神经退行性疾病重点实验室，河北省神经药理学重点实验室，张家口，075000，中国
  • 出版日期:2023-02-26 发布日期:2023-11-29
  • 通讯作者: 吴志刚，男，硕士生导师；研究方向：神经药理学；E-mail：wuzhigang1982@126.com
  • 作者简介:牛聪，男，硕士研究生；研究方向：神经药理学；E-mail：1944023227@qq.com
  • 基金资助:
    河北省省属高校基本科研业务费自然科学研究计划项目（No.JYT2021001），河北省卫生健康委医学科学研究课题计划项目（No. 20170863），河北北方学院博士科研启动基金项目资助

Research Progress of Traditional Chinese Medicine in the Treatment of Depression

NIU Cong, WU Zhi-gang   

  1. College of Pharmacy, Hebei North University, Zhangjiakou Key Laboratory of Traditional Chinese Medicine for the Prevention and Treatment of Neurodegenerative Diseases, Hebei Key Laboratory of Neuropharmacology, Zhangjiakou, 075000, China
  • Online:2023-02-26 Published:2023-11-29

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摘要：

抑郁症是一种常见的精神疾病，主要表现为持续的心情低落和情绪障碍，其发病机制与神经递质表达异常、炎性因子分泌、下丘脑-垂体-肾上腺轴紊乱、肠道菌群环境改变以及线粒体结构功能异常等诸多因素有关。目前临床上用来治疗抑郁症的药物面临着起效慢，治疗效果差，毒副作用明显等情况。近来中药抗抑郁作用被逐渐重视起来，研究发现许多中药个药、对药以及复方具有抗抑郁作用，本文通过对中药改善抑郁症研究文献的整理，以期为中药治疗抑郁症提供理论依据。

关键词: 中药, 抑郁症, 炎症, 脑肠轴, 线粒体

Abstract:

Depression is a common mental disease, mainly manifested in persistent depression and emotional disorders. Its pathogenesis is related to many factors, such as neurotransmitters, inflammatory factors, disorder of hypothalamic pituitary adrenal axis, environmental changes of intestinal flora, mitochondrial structure and function, and so on. At present, the drugs used to treat depression in clinic face the slow onset, poor treatment effect and obvious toxic and side effects. Recently, the antidepressant effect of traditional Chinese medicine has been gradually paid attention to. Research has found that many traditional Chinese medicine individual drugs, pairs of drugs and compounds have antidepressant effects. This paper collates the research literature on the improvement of depression by traditional Chinese medicine, in order to provide a theoretical basis for the treatment of depression by traditional Chinese medicine.

Key words: traditional Chinese medicine, depression, inflammation, brain-gut axis, mitochondrion