神经药理学报

神经药理学报 ›› 2022, Vol. 12 ›› Issue (3): 11-.DOI: 10.3969/j.issn.2095-1396.2022.03.003

• 专题论著 • 上一篇    下一篇

炎症相关衍生指标与急性心肌梗死研究进展

王家琦，吴路路，张飞飞，高曼，党懿，齐晓勇   

  1. 1 河北北方学院研究生院，张家口，075000，中国  2 河北省人民医院心血管内科，石家庄，050051，中国
  • 出版日期:2022-06-26 发布日期:2022-06-26
  • 通讯作者: 齐晓勇，E-mail：hbghxiaoyong_q@126.com
  • 作者简介:王家琦，E-mail：1186788423@qq.com
  • 基金资助:
    河北省自然科学基金项目（No.H2020307017），河北省2019 年度医学科学研究课题项目（No.20190237）

Research Progress of Inflammatory Related Derivative Indices and Acute Myocardial Infarction

WANG Jia-qi，WU Lu-lu，ZHANG Fei-fei，GAO Man，DANG Yi，QI Xiao-yong   

  1. 1 Graduate School of Hebei North University，Zhangjiakou，075000，China  2 Department of Cardiology，Hebei General Hospital，Shijiazhuang，050051，China
  • Online:2022-06-26 Published:2022-06-26

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摘要：

急性心肌梗死（acute myocardial infarction，AMI）是心血管疾病中最严重类型，可导致心律失常、心力衰竭甚至猝死，近年来研究表明炎症反应与AMI 的发生、发展及心肌梗死后的损伤修复密切相关。各种炎症细胞作为人体免疫系统的重要部分，参与了AMI 的发生及发展。中性粒细胞/ 淋巴细胞比值（neutrophil to lymphocyte ratio，NLR）、淋巴细胞/ 单核细胞比值（lymphocyte/monocyte ratio，LMR）及全身免疫炎症指数 （systemic immune inflammation index，SII）等炎症相关衍生指标可反映机体炎症状态，已被大量研究发现其在 AMI 诊断、治疗、预后及并发症方面存在一定预测价值。该文主要对炎症相关衍生指标在与AMI 中的作用进行综述，以期为AMI 发病机制及治疗提供新的依据。

关键词: 中性粒细胞, 急性心肌梗死, 动脉粥样硬化, 炎症

Abstract:

Acute myocardial infarction （AMI） is the most serious type of cardiovascular disease，which can lead to arrhythmia，heart failure and even sudden death. Recent studies have shown that inflammatory response is closely related to the occurrence and development of AMI and the damage repair after myocardial infarction. As an important part of human immune system，various inflammatory cells are involved in the occurrence and development of AMI. Inflammation-related derived indicators such as NLR，LMR and SII can reflect the inflammatory state of the body，and a large number of studies have found that they have certain predictive value in the diagnosis，treatment，prognosis and complications of AMI. This article mainly reviews the role of inflammation-related derived indicators in AMI，in order to provide a new basis for the pathogenesis and treatment of AMI.

Key words: neutrophil, acute myocardial infarction, atherosclerosis, inflammation

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