神经药理学报

神经药理学报 ›› 2022, Vol. 12 ›› Issue (1): 41-47.DOI: 10.3969/j.issn.2095-1396.2022.01.007

• 综述 • 上一篇    下一篇

缺血性脑损伤中的线粒体质量控制

张巧巧，范荣珍，景永帅，张丹参   

  1. 河北科技大学化学与制药工程学院，石家庄，050018，中国
  • 出版日期:2022-02-26 发布日期:2023-08-30
  • 通讯作者: 张丹参，博士生导师；研究方向：神经药理学；Tel：+86 - 0311 - 81668016，E - mail：zhangds2011@126.com
  • 作者简介:张巧巧，硕士研究生；研究方向：药理学；E - mail：1582040330@qq.com
  • 基金资助:
    河北省重点研发计划项目生物医药专项项目（No.20372509D）；河北省自然科学基金项目（No.H2020208032）

The Role of Mitochondrial Quality Control in Ischemic Brain Injury

ZHANG Qiao - qiao，FAN Rong - zhen，JING Yong - shuai，ZHANG Dan - shen   

  1. College of Chemical and Pharmaceutical Engineering，Hebei University of Science and Technology，Shijiazhuang， 050018，China
  • Online:2022-02-26 Published:2023-08-30

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摘要：

缺血性脑损伤是世界范围内引起高致死率、致残率的一种疾病。脑缺血/ 再灌注（ischemia/reperfusion， I/R）损伤是由于缺血缺氧区域的血流再灌注引起一系列级联反应。线粒体功能障碍一直被认为是缺血再灌注诱 导的神经元死亡的标志之一。脑缺血后线粒体从星形胶质细胞向受损伤的神经元转移会启动内源性神经保护机 制，从而为神经元提供能量的支持。本文分析讨论了线粒体在缺血性脑损伤的病理状态下的研究进展，缺血性脑 损伤对线粒体自噬和线粒体动力学的影响，介绍了线粒体免疫调节的情况，强调了线粒体转移对缺血性脑损伤 的作用以及线粒体在细胞间转移途径和机制，突出了线粒体作为治疗缺血性脑损伤的前景。

关键词: 缺血性脑损伤, 线粒体功能障碍, 线粒体自噬, 线粒体转移, 免疫调节

Abstract:

Ischemic brain injury is a disease that causes a high rate of mortality and disability worldwide. Cerebral ischemia - reperfusion （ischemia/reperfusion，I/R） injury is a cascade of reactions caused by bloodstream reperfusion in the ischemic and hypoxic area. Mitochondrial dysfunction has long been considered one of the hallmarks of ischemia - reperfusion - induced neuronal death. Mitochondrial metastasis from astrocytes to damaged neurons after cerebral ischemia initiates endogenous neuroprotective mechanisms that provide energy support to neurons. This article analyzes and discusses the research progress of mitochondria in the pathological state of ischemic brain injury，the effect of ischemic brain injury on mitochondrial autophagy and mitochondrial dynamics，introduces mitochondrial immunoregulation and mitochondria - related calcium ion homeostasis，emphasizes the role of mitochondrial metastasis on ischemic brain injury and the pathway and mechanism of mitochondrial metastasis between cells，and highlights the prospect of mitochondria as a treatment for ischemic brain injury.

Key words: ischemic brain injury, mitochondrial dysfunction, mitophagy, mitochondrial transfer, immunomodulation