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26 June 2021, Volume 11 Issue 3 Previous Issue    Next Issue

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Effect of Unilateral Basal Ganglia Hemorrhage on Neurological Function in Neonatal Rats ZHOU Shao-xiong, HU Jin-ping 2021, 11 (3):  1-4.  DOI: 10.3969/j.issn.2095-1396.2021.03.001 Abstract ( 85 )   PDF (1055KB) ( 47 )   Objective：To explore the effect of unilateral basal ganglia hemorrhage on neural function in neonatal rats. Methods：Fifty four neonatal rats were randomly divided into normal control group （NC，n = 18），sham operation group （SH，n = 18） and intracerebral hemorrhage group （CH，n = 18）. 25 μL autologous blood was injected into the left caudate nucleus to establish the model of basal ganglia hemorrhage. NC group was given normal feeding without any intervention. In SH group，microinjection pump needle was inserted into the left caudate nucleus without blood injection. Other treatments were the same as those in CH group. The neurological function score at different time points，the results of daytime opening experiment and evening opening experiment were compared among the three groups. Results：After modeling，the neurological function of rats showed different degrees of damage. SH group rats had relatively mild neurological damage symptoms，which could recover in a short time，and all recovered 72 hours after operation. The changes of muscle tension and hemiplegia occurred in CH group. Compared with SH group and NC group，the neurological function score of CH group was significantly higher on the 1st and 3rd day （P<0.05）. There was no significant difference in neurological function scores between SH group and NC group on the 1st，3rd，7th and 14th day （P>0.05）.Compared with SH group and NC group，CH group had more grooming times，upright times and crossing grid times （P<0.05）. Compared with SH group and NC group，CH group had more upright times and crossing grid number （P<0.05）. Conclusion：The development of rats will appear unilateral basal ganglia focal hemorrhage injury symptoms，with compensatory，repairable and other basic characteristics，and most of them will not appear serious neuromotor dysfunction left behind，but will cause non selective attention level decreased，autonomic activity increased and other symptoms. Related Articles | Metrics

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Study on Nerve Function Injury Induced by Dazolam and Its Mechanism YANG Rong, SUN Zhen-qin, XIE Wen-juan, NIE Bin, SUN Fu-bang 2021, 11 (3):  5-9.  DOI: 10.3969/j.issn.2095-1396.2021.03.002 Abstract ( 173 )   PDF (5646KB) ( 52 )   Objective：To investigate the neurologic impairment induced by sedative midazolam and its mechanism. Methods：72 rats were divided into normal saline control group，midazolam group，dexmedetomidine group，each group contained 24 rats. Neuron specificity enolization enzyme（NSE），central nervous specificity protein （S100β），cell death receptor level of Fas，escape latency，swimming speed，through the original number were compaied in three groups. The pathological sections of NSE，S100β and Fas were analyzed. Results：In midazolam group，the levels of NSE，S100β and Fas were higher，the escape latency was longer，and the number of passing through the original platform was less（P<0.05）. Conclusion：Midazolam has a significant effect on neurological impairment and learning and memory functions. Related Articles | Metrics

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Clinical Efficacy of Butylphthalide Combined with Sertraline in the Treatment of Post-stroke Depression and Its Effect on Inflammatory Factors DONG Chuan-zhan, WANG Li-chun 2021, 11 (3):  10-14.  DOI: 10.3969/j.issn.2095-1396.2021.03.003 Abstract ( 105 )   PDF (1069KB) ( 12 )   Objective：To analyze the changes of emotion，cognitive function and inflammatory state in patients with post-ischemic stroke depression （PISD） after treatment with butylphthalide and sertraline. Methods：126 PISD patients who met the screening criteria were randomly divided into control group and experimental group. Sertraline and butylphenylpeptide combined with sertraline were used to treat PISD patients，and the inflammation status and inflammation status of the two groups were compared and analyzed. Results：Before treatment，there was no significant difference in neurological function，depressive state，cognitive function and HPA axis function between the two groups in PISD patients.After treatment，the neurological function，depressive state，cognitive status and HPA axis function of the two groups were improved. Compared with the control group，the NIHSS and Hamilton Depression Scale（HAMD） scores of the experimental group were lower，while the MMSE scores were significantly higher. The HAMD score was low while the Mental Status Assessment Scale （MMSE） score was significantly high. The levels of serum corticotropin releasing hormone （CRH），corticotropin（ACTH） and cortisol （Cor） in the experimental group were significantly lower than those in the control group. Compared with the control group，hs-CRP，TNF-alpha，IL-8 in the experimental group were significantly lower （P<0.05）. Compared with the control group，the total number of patients cured in the experimental group was 60 （95.2%），which was significantly higher than that in the control group，and the difference between the two groups was significant （P<0.05）. Compared with the control group，the experimental group had significantly higher scores in four aspects of physical health，mental health，social function and material life. Conclusion： Butylphthalide combined with sertraline can effectively improve the level of inflammatory factors in PISD patients，improve HPA axis function，improve cognitive function，and reduce the severity of mental injury and depression. Related Articles | Metrics

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Study on the Mechanism of Single Chinese Medicine Extract in the Prevention and Treatment of Rheumatoid Arthritis XU Fei, LI Xue-Jun 2021, 11 (3):  15-19.  DOI: 10.3969/j.issn.2095-1396.2021.03.004 Abstract ( 107 )   PDF (1046KB) ( 42 )   Rheumatoid arthritis（RA） is a common autoimmunedisease in rheumatology department with unknown etiology.Currently，non steroidal anti-inflammatory drugs，hormones and immunosuppressants are the main treatment options in clinic.Although the symptoms improve rapidly，there are many side effects（such as gastrointestinal reactions，liver and kidney function damage，etc.），and it is easy to relapse，which limits the follow-up treatment of patients.Therefore，it is urgent to find safe and effective drugs.In recent years，a large number of studies have shown that single Chinese medicine extract has obvious advantages in the prevention and treatment of rheumatoid arthritis.This paper reviews the mechanism of single Chinese medicine extract in the treatment of rheumatoidarthritis，in order to provide reference for the experimental research and clinical application of rheumatoid arthritis. Related Articles | Metrics

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Research Progress on the Protective Effect of Astrocytes in Cerebral Ischemia-Reperfusion Injury GENG Yu-han, ZHANG Dan-shen 2021, 11 (3):  20-24.  DOI: 10.3969/j.issn.2095-1396.2021.03.005 Abstract ( 103 )   PDF (2146KB) ( 42 )   Ischemic cerebrovascular disease （ICVD） is a common disease in clinical diseases，accounting for more than 70% of cerebrovascular diseases. The number of glial cells in the nervous system is the largest，far more than neurons. The mitochondrial function of astrocytes is impaired，resulting in problems in the survival and normal physiological function of neurons. Connexin is the key protein to perform this function. Connexin constitutes the gap junction channel and plays an important role in the pathological process.This article reviews the progress of the protective effect of gap junction protein 43 of astrocyte on cerebral ischemia. Related Articles | Metrics

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Research Progress on Drugs for Prevention and Treatment of Acute Radiation Syndrome WANG Jia, YOU Si-han, GUO Chun-yan 2021, 11 (3):  25-32.  DOI: 10.3969/j.issn.2095-1396.2021.03.006 Abstract ( 123 )   PDF (1091KB) ( 62 )   Acute radiation syndrome （ARS） is a systemic disease caused by exposure to large doses of ionizing radiation in a short period of time. It can be divided into bone marrow type （1~10 Gy），intestinal type （10~50 Gy） and brain type （>50 Gy）. ARS is mainly manifested as hematopoietic system inhibition and immune function impairment. This article introduces the research progress of drugs for the prevention and treatment of acute radiation syndrome with the main functions of restoring the hematopoietic system，enhancing immune function and improving complications. Related Articles | Metrics

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Neuroprotective Effect of Estrogen-Mediated Mitochondrial Pathway DAI Yue-ying, ZHAO Yu-wei, YAO Si-fan, SHEN Li-xia 2021, 11 (3):  33-42.  DOI: 10.3969/j.issn.2095-1396.2021.03.007 Abstract ( 112 )   PDF (1164KB) ( 19 )   Alzheimer’s disease（AD） is a multifactorial disease with cognitive and executive dysfunction as the main clinical manifestations. The pathogenesis of AD is Aβ cascade and abnormal tau protein，etc.. Epidemiological investigation showed that the incidence of AD in postmenopausal women was 1.5~3.0 times higher than that in men of the same age，estrogen either directly or indirectly affects mitochondria. In addition，because mitochondria are regarded as the energy body of cells and the key regulator of neuronal viability during excitotoxicity，the mitochondrial mechanism of AD has also become the research area of AD pathogenesis. Aβ can bind directly to the mitochondrial membrane，thus changing the dynamics and function of mitochondria，leading to abnormal energy metabolism，resulting in a series of chain reactions such as apoptosis. Studies have shown that mitochondrial dysfunction exacerbates Aβ deposition and tau abnormal phosphorylation，which in turn promotes mitochondrial injury and induces apoptosis through a mitochondrial dependent apoptotic pathway. This article reviews the neuroprotective effect of estrogen through mediating mitochondrial pathway in the case of AD，in order to provide some basic theoretical thinking for the prevention and treatment of AD. Related Articles | Metrics

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Regulation of Mitochondrial Autophagy and Its Role in Cerebral Ischemia-Reperfusion Injury XIE Jia-jia, SUN Ting, ZHANG Dan-shen 2021, 11 (3):  43-49.  DOI: 10.3969/j.issn.2095-1396.2021.03.008 Abstract ( 235 )   PDF (1118KB) ( 118 )   As a regulatory mechanism involved in cell metabolism and organelle renewal，autophagy plays an important role in the physiological and pathological processes of the body. Mitophagy，as a type of cell target-specific autophagy，can identify and remove functionally impaired mitochondria and achieve mitochondrial quality control. Mitochondria mainly regulate autophagy through Parkin-dependent and non-Parkin-dependent pathways，thereby affecting the body’s function. Studies have shown that mitochondrial autophagy is closely related to the process of cerebral ischemia-reperfusion injury，but its role in cerebral ischemia-reperfusion injury has been controversial. This article mainly summarizes the mechanism of mitochondrial autophagy and the way in which mitochondrial autophagy participates in cerebral ischemia-reperfusion injury. Related Articles | Metrics

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Studies on the Role of Focal Adhesion Kinase in Diseases HE Jin-zhao, YANG Bao-xue 2021, 11 (3):  50-64.  DOI: 10.3969/j.issn.2095-1396.2021.03.009 Abstract ( 222 )   PDF (1251KB) ( 96 )   Focal adhesion kinase （FAK） as a crucial component of focal adhesions （FAs） plays an important role in intracellular and extracellular signal transduction. FAK is a non-receptor tyrosine kinase and mainly regulated by integrins，growth factors and G-protein-coupled receptors，which mediates various bioactivities，such as cell migration，invasion，proliferation，differentiation and angiogenesis. A wide array of studies have demonstrated that abnormal expression and activation of FAK were critically involved in the pathogenesis of cardiovascular diseases，hepatic and renal injuries，lipometabolism，immunoregulation and cancer，in which were closely related to poor prognosis. In recent years，with the development of FAK animal models and inhibitors，targeting FAK has been recognized as new treatment for diseases. Most FAK inhibitors show promising preclinical effect without significant adverse effect and several are undergoing clinical trials. This review summarizes the studies on the role of FAK in diseases and related animal models and inhibitors to clarify the underlying mechanism and therapeutic prospect. Related Articles | Metrics