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26 October 2020, Volume 10 Issue 5 Previous Issue    Next Issue

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Application of Astragalus Injection in Intestinal Ischemia-Reperfusion Injury in Rats HAO Zhan-wei, WU Xing-xing 2020, 10 (5):  1-4.  DOI: 10.3969/j.issn.2095-1396.2020.05.001 Abstract ( 63 )   PDF (1111KB) ( 9 )   Objective：To investigate the application of Astragalus injection in intestinal ischemia-reperfusion liver injury in rats and its influence on the expression levels of Bax and Bcl-2. Methods：9 healthy adult male Wistar rats were randomly divided into 3 groups：Sham group，model group （IIR group） and Astragalus injection group （Astragalus group），with 3 rats in each group. The 3 groups were divided into 3 different phases（each time phase was 1 rats） according to the time of reperfusion（ 1，3，6 h）. After the end of the experiment，the expression levels of Bax and Bcl-2 in the left lobe of rat liver were taken as the experimental standard，and the expression levels of Bax and Bcl-2 in all specimens were detected by MIAS-2000 medical image analysis and immunohistochemical method，and the apoptosis index（AI） of liver tissues was detected by the TUNEL technique. Results：Compared with Sham group，the expression levels of Bax and Bcl-2 in three different phases of IIR group and Huangqi group were significantly increased （P<0.05），while those of Bcl-2/Bax and Bcl-2/Bax in three different phases of IIR group and Astragalus group were decreased （P<0.05）. Compared with the IIR group，the reperfusion of bcl-2/Bax and Bcl-2 in the astragalus group at 1，3 and 6 h was significantly increased，while the level of Bax was decreased （P<0.05）. There was no significant difference between different phases in the same group （P>0.05）. Compared with Sham group，AI of IIR group and Huangqi group were significantly improved at different phases of reperfusion at 1，3 and 6 h （P<0.05）. Compared with IIR group，AI of astragalus group in three different phases was significantly reduced （P<0.05）. There were significant differences between IIR group and Astragalus group in different phases （P<0.05），and reperfusion was the highest for 6 h. Conclusion：IIR can lead to liver injury in rats，and the expression levels of Bcl-2 and Bax are increased. The mechanism of action of Astragalus injection may be to regulate the two expressions，alleviate the apoptosis of liver cells，and have a protective effect on the liver. Related Articles | Metrics

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Effect of Acupuncture Combined with Medicine on Depressive Symptoms of Alzheimer’s Disease XIE bin, HUANG Zhi-yuan, LIN Duo-duo, YANG Fu-long, XIE Yi-bin 2020, 10 (5):  5-8.  DOI: 10.3969/j.issn.2095-1396.2020.05.002 Abstract ( 73 )   PDF (1126KB) ( 11 )   Objective：To explore the effect of acupuncture combined with medicine on Alzheimer’s disease patients with depressive symptoms. Methods：60 patients with Alzheimer’s disease complicated with depressive symptoms in our hospital from December 2017 to December 2019 were randomly divided into control group （conventional western medicine treatment） and observation group （acupuncture combined with Kongsheng Zhenzhong Dan modified treatment），and the self rating Depression Scale （SDS），Hamilton Depression Scale （HAMD） and simple mental state assessment MMSE and the total effective rate were compared between the two groups before and after treatment. Results：Compared with the control group，the SDS score and HAMD score of the observation group were significantly lower （P<0.05）；the MMSE score of the observation group was significantly higher than that of the control group （P<0.05）；the total effective rate of the observation group was significantly higher than that of the control group （P<0.05）. Conclusion：Acupuncture combined with kongshengzhenzhongdan can achieve ideal effect in the treatment of Alzheimer’s disease patients，which can promote the obvious improvement of depression symptoms of patients，so as to improve their mental state，improve the treatment effect，and have a positive effect on improving the prognosis of patients. Related Articles | Metrics

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Clinical Observation of Butorphanol Combined Dexmedetomidine with in Vertebroplasty under Local Anesthesia in Elderly Patients LIU Hao, LING Jian-zhong, ZHANG Xiao-qin, CAI Hong-hong, XU Bo 2020, 10 (5):  9-13.  DOI: 10.3969/j.issn.2095-1396.2020.05.003 Abstract ( 94 )   PDF (1142KB) ( 9 )   Objective：To investigate the safety and efficacy of butorphanol combined with dexmedetomidine in vertebroplasty under local anesthesia in elderly patients. Methods：Sixty patients scheduled to undergo elective percutaneous vertebroplasty （PVP） were enrolled and randomly assigned into two groups，dexmedetomidine + butorphanol group（ DB group，n=30）and dexmedetomidine + normal saline group （DS group，n=30）. All patients received intravenous infusion of dexmedetomidine before operation （loading dose：0.5 μg·kg-1，maintenance dose：0.5 μg·kg-1·h-1）. Simultaneously，patients in DB group were given intravenous injection of butorphanol 15 μg·kg-1，while patients in DS group were given intravenous injection of the same volume of normal saline. The mean arterial pressure （MAP），heart rate （HR），VAS and Ramsay scores were recorded 5 min after entering the operation room （T0），at the time of changing of positon （T1），trocar insertion （T2），cement injection （T3） and the end of operation （T4）. The intraoperative adverse events were also recorded，such as respiratory depression and bradycardia. Results：Compared with DS group，the MAPs were lower at T1~T4 and HRs were lower at T1~T3（P<0.05）；the Ramsay score between DS group and DB group at T0~T4 were similar （P>0.05）； however，the VAS scores in DB group were lower at T1~T2 than that in DS group （P<0.05）. There was no statistical difference existed when comparing the adverse events，such as respiratory depression and bradycardia，among two groups （P>0.05）. Conclusion：Dexmedetomidine combined with butorphanol could be safely used in vertebroplasty under local anesthesia. It could help to maintain the hemodynamic stability，reduce pain intensity and did not increase the incidence of adverse events during surgery. Related Articles | Metrics

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Determination of Atractone in Tangpingjian by Gas Chromatography TIAN Jia-ming, YU Xiao-hong, WANG Yin-yue, WANG Xu, WANG Zhi-bao, WANG Jin, LU Jin-ming 2020, 10 (5):  14-17.  DOI: 10.3969/j.issn.2095-1396.2020.05.004 Abstract ( 90 )   PDF (1171KB) ( 10 )   Objective：To establish a gas chromatography method for the determination of atractylone in TangpingJian. Method：PEG-20M capillary column （30 m×0.25 mm×0.25 μm） was used as the chromatographic column. The temperature was programmed with the inlet temperature of 290 ℃ and detector temperature of 300 ℃，and the detector was hydrogen flame ionization detector （FID）. The carrier gas was nitrogen with the flow rate of 1 mL·min-1， and naphthalene was used as the internal standard substance. Results：The separation of the atractylone and the internal standard substance was good，and the average recovery rate and RSD was 100.1% and 2.64%，respectively. The atractylone content in the Tangpingjian was 1.13 mg·g-1. Conclusion：The established gas chromatographic method is simple，highly sensitive and accurate. It can be used for the detection of atractylone content in TangpingJian. Related Articles | Metrics

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Research Progress on Extraction Technology, Structure Analysis and Quality Control of Salvia Miltiorrhiza Polysaccharide WANG Fei-fan, MA Yun-feng, JING Yong-shuai 2020, 10 (5):  18-23.  DOI: 10.3969/j.issn.2095-1396.2020.05.005 Abstract ( 145 )   PDF (1199KB) ( 23 )   Salvia miltiorrhiza Bunge is a commonly used traditional Chinese medicine in clinic. It contains many chemical components. Polysaccharide is one of its main chemical components. It has the functions of protecting heart muscle，protecting liver，antitumor，antioxidation，antiinflammation，etc. It has been widely concerned by domestic and foreign Scholars. The extraction，structure analysis，pharmacological action and quality control methods of Salvia miltiorrhiza polysaccharide were reviewed in this paper. The purpose is to provide reference for further research and development of Salvia miltiorrhiza polysaccharide. Related Articles | Metrics

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Research Progress on Clinical Application of Obucaine LI Jia-ying, ZHANG Dan-shen 2020, 10 (5):  24-27.  DOI: 10.3969/j.issn.2095-1396.2020.05.006 Abstract ( 241 )   PDF (1091KB) ( 49 )   Obucaine is a commonly used topical anesthetic，which has the advantages of quick anesthetic effect and strong analgesic effect，so it is a commonly used topical anesthetic in ophthalmic surgery. This paper summarizes the examples of clinical application of obucaine in recent years，in order to provide reference value for clinical research. Related Articles | Metrics

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Research Progress of FOXK1 in Neoplastic Diseases GAO Yan-song, ZHANG Zhi-hua, XU Kai-lun 2020, 10 (5):  28-32.  DOI: 10.3969/j.issn.2095-1396.2020.05.007 Abstract ( 187 )   PDF (1167KB) ( 15 )   Forkhead box K1 （FOXK1） is a member of the Fox family，which is composed of more than 730 amino acids. It is characterized by a relatively conservative “forkhead” DNA domain，which can regulate various cellular processes. It is highly expressed in most tumors and promotes tumor progression. Its main mechanism is to regulate cell cycle，promote cell proliferation，and induce EMT（ epithelial mesenchymal transition） in different ways. This article mainly discusses the expression and significance of foxk1 in most tumors. Related Articles | Metrics

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Research Progress on Potential Treatment of Alzheimer’s Disease with Alkaloids SUN Li-cong, ZHANG Dan-shen 2020, 10 (5):  33-37.  DOI: 10.3969/j.issn.2095-1396.2020.05.008 Abstract ( 111 )   PDF (1182KB) ( 32 )   In recent years，although the research of Alzheimer’s disease is getting deeper and deeper，its mechanism is not explicit and the clinical effect of synthetic drugs is not significant，so the development of effective components of natural drugs has become a hot spot. Alkaloids，a naturalmedicine component，exist widely in nature. Because of their easy access to materials and a plenty of biological activities，such as anti-aging，anti-tumor，nerve protection，etc.，more and more researches have been made on them. In this paper，the potential treatment of AD by alkaloids in natural plants is reviewed，which provides theoretical basis for the treatment and research of AD. Related Articles | Metrics

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Current Situation and Prospect of Alzeimer’s Disease Treatment WANG Si-yi, LI Xian-xiang, LIU Yi-zhou, DU Shuang, GE Chao, LIU Si-si 2020, 10 (5):  38-42.  DOI: 10.3969/j.issn.2095-1396.2020.05.009 Abstract ( 253 )   PDF (1167KB) ( 60 )   Alzheimer’s disease is a degenerative neurological disease that is difficult to detect at its onset and gradually develops over time. The disease has become the fourth killer after heart disease，tumor，and stroke. This disease affects many systems of the human body，and the pathogenesis is more complicated and related to many factors. The main manifestations of the patients are memory，learning dysfunction and decline in daily life ability. The current treatment drugs mainly focus on improving clinical symptoms，and there are no effective drugs that can reverse or prevent the progression of the disease. This article reviews the incidence，pathogenic factors and related hypotheses of Alzheimer’s disease，and summarizes the current clinical treatment drugs such as cholinesterase inhibitors and N-methyl-D-aspartate receptors （NMDA） antagonist，with a view to provide a reference basis for future scientific research. Related Articles | Metrics

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Advances in Research on Treatment of Ulcerative Colitis with Chinese and Western Medicine ZHANG Jian-mei, ZHANG Dan-shen 2020, 10 (5):  43-47.  DOI: 10.3969/j.issn.2095-1396.2020.05.010 Abstract ( 89 )   PDF (1170KB) ( 12 )   Ulcerative colitis （UC） is a chronic non-specific inflammatory disease. The pathogenesis is still unclear. In order to further understand the diagnosis and treatment of ulcerative colitis，this article has reviewed relevant literature for nearly ten years. The treatment of ulcerative colitis is reviewed and provides a reference for future clinical treatment. Related Articles | Metrics

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Research Progress on the Effect of Sleep Disturbance on Infertility LI Feng-rui , LI Wei 2020, 10 (5):  48-54.  DOI: 10.3969/j.issn.2095-1396.2020.05.011 Abstract ( 168 )   PDF (1160KB) ( 22 )   Related Articles | Metrics

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Study on the Neuroprotective Mechanism of Quercetin in Alzheimer’s Disease ZHAO Yu-wei, ZHEN Yan-jie, DAI Yue-ying, SHEN Li-xia 2020, 10 (5):  55-64.  DOI: 10.3969/j.issn.2095-1396.2020.05.012 Abstract ( 242 )   PDF (1251KB) ( 31 )   Alzheimer’s disease （AD） is characterized by progressive cognitive decline and memory loss，and its pathogenesis is complex. At present，no effective drugs and therapeutic approaches have been found clinically to fundamentally prevent and cure AD. Quercetin is a flavonoid phytoestrogen that simulates estrogen stimulation of estrogen receptors to produce weak estrogen activity and has a protective effect on the nervous system. Quercetin has high biological activity，wide source，no teratogenicity，no carcinogenesis，no lethal effect，so it has been widely concerned. In this review，the biological activity of quercetin，its neuroprotective effect on AD and its mechanism of action were reviewed，with a view to providing reference for the research of related drugs for AD. Related Articles | Metrics