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    26 December 2017, Volume 7 Issue 6 Previous Issue    Next Issue

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    Value of Neuroimaging in Vascular Cognitive Impairment
    BAI Yan-chang,JIA Yan-li,WANG Jian-hua
    2017, 7 (6):  1-6.  DOI: 10.3969/j.issn.2095-1396.2017.06.001
    Abstract ( 102 )   PDF (1000KB) ( 131 )  

    Vascular cognitive impairment (VCI) is a cognitive spectrum disease,caused by risk factors of cerebrovascular diseases (hypertension,diabetes,hyperlipidemia),and obvious cerebrovascular diseases (such as cerebral infarction,cerebral hemorrhage) or less obvious cerebrovascular diseases (such as loose white matter,chronic cerebral ischemia). It encompasses the full range of cognitive defcits from mild cognitive impairment to dementia. Since clinical signs and symptoms are often neither sufficient to allow for a final diagnosis,nor differentiate among the various etiologies,however neuroimaging can display the visualization of ischemic and hemorrhagic injury of gray and white matter,which not only plays an important role in the diagnosis of patients with impaired cognition,but also explore the pathophysiology of VCI. This review summarizes the application of neuroimaging methods in VCI diagnosis nowdays,including computed tomography (CT),high resolution magnetic resonance imaging(HRMRI),diffusion tensor imaging (DTI),magnetic resonance imaging spectroscopy (MRS),and dynamic contrastenhanced MRI (DCEMRI) and blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI).

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    Methods and Evaluation of Animal Models of Induced Acute Respiratory Distress Syndrome
    ZHANG Dan-shen,ZHANG Rui-juan
    2017, 7 (6):  7-14.  DOI: 10.3969/j.issn.2095-1396.2017.06.002
    Abstract ( 187 )   PDF (1034KB) ( 293 )  

    Acute respiratory distress syndrome (ARDS) is an acute respiratory failure caused by diffuse alveolar damage( DAD) and capillary membrane damage,which is characterized by non-cardiac pulmonary edema and inflammation. Different animal models of lung injury have been used to study the mechanism of lung in-jury,for example,animal models of ARDS such as traumatic acute lung injury,infectious toxic lung injury,chemical lung injury,and mixed lung injury. It is helpful to establish ideally acute lung injury experimental models to explain the mechanism and treatment of human ALI. The purpose of this paper is to summarize the methods, advantages and disadvantages of existing animal models.

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    Research Progress of Solid Lipid Nanoparticles
    GUO Tong-lin,WANG Cui,SHEN Li-xia
    2017, 7 (6):  15-21.  DOI: 10.3969/j.issn.2095-1396.2017.06.003
    Abstract ( 198 )   PDF (1100KB) ( 246 )  

    Solid lipid nanoparticles (SLN) is a solid colloidal drug delivery system based on natural or synthetic solid lipids embedded in lipophilic nuclei or coated on lipopolipid surfaces. The particle size of SLN is 10~1 000 nm. The carriers used in solid lipid nanoparticles are lipid-like compounds with low toxicity,good biocompatibility and biodegradability. It is a new generation of submicron drug delivery system developed in the early 1990s. Solid lipid nanoparticles have the advantages of controlling drug release,avoiding drug degradation or leakage,and good targeting. This paper summarized and analyzed the research progress of solid lipid nanoparticles,including the basic components,preparation methods,factors affecting drug loading (DL) and encapsulation efficiency (EE),drug delivery system release,the application and advantages of solid lipid nanoparticles.

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    Research Progress on Anticancer Effects and Dosage Forms of Osthole
    ZHANG Nan,ZHANG Dan-shen
    2017, 7 (6):  22-29.  DOI: 10.3969/j.issn.2095-1396.2017.06.004
    Abstract ( 133 )   PDF (1017KB) ( 104 )  

    Osthole is the main active component of the umbelliferous plant Cnidium. Many clinical and modern pharmacological studies have shown that osthole has the effects of antihypertensive,antiarrhythmic,antitumor,antimutagenic and slowing the progression of neurodegenerative diseases. Osthole has certain protective effects on various cancers,such as glial cancer,breast cancer,pancreatic cancer,lung cancer,gastric cancer,etc. However,as a coumarin compound,osthole has the shortcoming of poor oral absorption and low bioavailability. In order to improve its shortcomings,it is necessary to prepare new dosage forms of osthole,such as liposomes,micelles,solid dispersions etc.,thus to improve its clinical effects. This paper summarizes the pharmacological effects and dosage for osthole in the treatment of cancer in recent years,hope it can provide help for future research.

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    Progress in the Comorbidity of Depression and Anxiety
    LIANG Hui,CHENG Tao,LIANG Jian-hui
    2017, 7 (6):  30-35.  DOI: 10.3969/j.issn.2095-1396.2017.06.005
    Abstract ( 162 )   PDF (1018KB) ( 133 )  

    It is traditionally thought that anxiety disorder and depressive disorder are categorically defined as two individual psychiatric disorders. As clinical practice and epidemiological studies show,however,the comorbidity of depression and anxiety is prevalent and of poorer outcomes than either disorder alone. In this review,the concepts,clinical features,therapeutic managements,and animal models related to the comorbidity of depression and anxiety are well addressed. In addition,establishing the novel animal models and developing the new agents of both anti-depression and-anxiety are discussed to improve its diagnosis,treatment,and medical prevention.

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    Research Progress of Aging-Related Ggene Clk1
    ZHAO Xue-ping,ZHANG han,DONG Xiao-hua
    2017, 7 (6):  36-40.  DOI: 10.3969/j.issn.2095-1396.2017.06.006
    Abstract ( 154 )   PDF (1019KB) ( 201 )  

    Clk1,a mitochondrial enzyme involved in coenzyme Q biosynthesis,plays an role in the aging process. It was found that the loss of Clk1/Mclk1 gene could lead to prolonging the life span of nematodes and mice,but the specific mechanism was not clear. In this review,we summarized and discussed the function of Clk1 gene in organism.

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    Autophagy and Bone Mmorphogenetic Proteins in Diseases and Their Relationship
    HAO Jun-rong,ZHANG Dan-shen,GONG Yue-wen
    2017, 7 (6):  41-49.  DOI: 10.3969/j.issn.2095-1396.2017.06.007
    Abstract ( 108 )   PDF (1045KB) ( 85 )  

    Autophagy is often described as a double-edged sword in diseases. Strategies utilizing autophagy either for activating or inhibiting it could find a broad application for innovative treatment. Some of the bone morphogenetic proteins (BMPs) have been found to be causative factors for certain human disease,while others have been shown to have a strong association with other diseases. Whether there are some associations between autophagy and BMPs expression in the same disease such as neurodegeneration remains to be investigated. In this brief review,we summarized autophagy in different conditions and BMPs expression in the same conditions respectively in order to discover some associations between autophagy and BMPs expression. Some associations are found in signaling pathway of both autophay and BMPs.

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    Research Progress of Cerebral Ischemia Reperfusion Injury and Its Mechanisms Related to Astrocytes
    LI Jiang-man,WANG Yi-di,WANG Feng-ping,LI Wei
    2017, 7 (6):  50-59.  DOI: 10.3969/j.issn.2095-1396.2017.06.008
    Abstract ( 155 )   PDF (1074KB) ( 118 )  

    The mechanism of cerebral ischemia-reperfusion injury has not been fully elucidated,and various mechanisms are mutually influential and complicated,such as inflammatory response,oxidative stress,excitatory amino acid toxicity,intracellular calcium overload,energy metabolism disorder and apoptosis and so on. Astrocytes widely distributed between neurons,can support,separate,and regulate neurons. And they have important functions on the nervous system,such as absorbing glutamate outside the synapse,regulating K+ homeostasis,and buffering excessive production of reactive oxygen species. In this paper,we review the mechanism of astrocytes in cerebral ischemia-reperfusion injury in recent years,and provide a basis and new ideas for the study of astrocytes as a target to improve cerebral ischemiareperfusion injury.

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    The Research Progress of the Antioxidant Effect of Natural Compounds in the Treatment of Ischemic Stroke
    ZHAN Jia-hong,JIAN Wen-xuan,WAN Jiang-fan,et al
    2017, 7 (6):  60-64.  DOI: 10.3969/j.issn.2095-1396.2017.06.009
    Abstract ( 138 )   PDF (973KB) ( 165 )  

    Stroke is a common disease with high incidence,mortality and disability, which poses a huge threat to human life,social economy,and medical resources. Ischemic stroke patients account for 80% of stroke patients,and reperfusion after ischemia induces more intense nerve damage,including excitotoxicity,oxidative stress,and inflammatory response. Among them,oxidative stress is one of the most critical causes of injury. China’s natural products are rich in resources,and traditional medicine has a long history and rich experience. It has unique advantages in researching and developing high-efficiency,low-toxic,safe and inexpensive natural products from natural resources,which has improve ischemic stroke at home and abroad. The level of treatment has important medical value.In this paper,natural compounds such as butylphthalide,salvianolic acid,and protocatechuic aldehyde are reviewed. The mechanism of action of these compounds in the treatment of ischemic stroke is related to its antioxidant activity.

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