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26 February 2014, Volume 4 Issue 1 Previous Issue    Next Issue

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Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B Tang Min-ke，Fan Yue，Liu Chang-suo，Zhang Jun-tian 2014, 4 (1):  1-10.  Abstract ( 3248 )   PDF (10735KB) ( 1502 )   This paper reviewed the effect of Salvianolic acid-B (Sal B) on toxicity of amyloid β-protein (Aβ), tau protein and PC12 cells and SH-SY5Y cells apoptosis induced by Aβand tau protein, and on neurogenesis and angiogenesis．The results showed that Sal B could decrease the toxicity of Aβ by inhibiting Aβ aggregation and fibril formation, and protect cells damaged by Aβ．Hyperphosphoylation of tau protein could be attenuated by Sal B．Sal B has also been proved to promote neurogenesis and angiogenesis．Based on the neuroprotective effect of Sal B, it may be a potential medicine for treatment of neurodegenerative disease. References | Related Articles | Metrics

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Effects of Methotrexate on Acute Phrase of Spinal Cord Contusion-Induced Lipid Peroxidation in Rats ZHANG Si, GU Bing, WANG Shuo-yu, LI Hua-nan, ZHANG Guo-fu, ZHANG Shui-yin 2014, 4 (1):  11-16.  Abstract ( 3052 )   PDF (1182KB) ( 2192 )   Objective：This study examined the effect of methotrexate on acute phrase of spinal cord contusion-induced lipid peroxidation in rats and the neuroprotective mechanism of its anti-oxidant action. Methods: Rat spinal cord contusion model was prepared by Pinpoint Precision Cortical Impactor™ apparatus and then methotrexate (0.5mg•kg-1•BW) was subcutaneously administrated at posttraumatic 30 min. ELISA method was used to determine the content of malondialdehyde（MDA）and 8-iso-PGF2α in plasma and 4-hydroxynonenal-His adduct (HNE) in injury tissue. Results: Posttraumatic 1, 3, 6, 12, 24, 48, 72 h, the contents of MDA, 8-iso-PGF2α and HNE in the methotrexate group were all lower than those in the model group, which achieved statistical significance at posttraumatic 6, 12 h (P<0.05).  At posttraumatic 12 h, the content of 8-iso-PGF2α in plasma was also significantly lower than that in the model group (P<0.05). Conclusion: The appropriate doses, methotrexate could prevent secondary injury of spinal cord, which may be related to inhibiting or reducing the lipid peroxidation. References | Related Articles | Metrics

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Protective Effects of He Ying An Xin Fang on Free Radical Injury Induced by H2O2 in Myocardium Rats HE Wei, LI Yong-min, ZHANG Hai-xia, ZHU Juan, GAO Yue 2014, 4 (1):  17-19.  Abstract ( 2479 )   PDF (978KB) ( 2065 )   Objective:To investigate the protective effects and mechanisms of he ying an xin fangon myocardium injury caused by H2O2. Methods: Hydrogen peroxide (H2O2) was adopted to establish the rat embryonic cardiomyocytes oxidative stress insult model , and the experiment was divided into 5 groups: cardiomyocytes were incubated by H2O2 (200 μmol·L-1) for 2h as model group, the non- H2O2 as control group, and the extraction of he ying an xin fang (500, 250, 125 mg·kg-1) as therapeutic groups. The cell viabilityby 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT), content of malondialdehyde (MDA) and activity of lactate dehydrogenase (LDH) were measured. Resulds: Cell viabilityby MTT: compared with control group, cell Viabilityby MTT was decreased significantly in H2O2 group (P< 0.01), while he ying an xin fang had no significant effect on cardiac myocytes of cell viability. Content of MDA: compared with that of H2O2 group, the content of MDA was decreased in he ying an xin fang groups significantly (P< 0.05). Content of LDH: compared with that of control group, the content of LDH was decreased in he ying an xin fang groups significantly (P< 0.05). Conclusion: He ying an xin fang has significant protective effects on free radical injury induced by H2O2 in myocardium rats, and it may be related to the inhibition of lipid peroxidation. References | Related Articles | Metrics

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Progress in Studies of Glutamatergic Neurotransmission in the Pathogenesis of Depression LI Jing, SUN Jian-dong, YUAN Yu-he, CHEN Nai-hong 2014, 4 (1):  20-24.  Abstract ( 3599 )   PDF (893KB) ( 3298 )   The “monoamine hypothesis” of depression, which posits that depression is caused by decreased monoamine function in the brain, originated several decades ago. Although these monoamine-based agents are potent antidepressants, the cause of depression is far from being a simple deficiency of central monoamines. The glutamatergic system also plays important roles in the pathophysiology of major depressive disorder. This paper summarizes the physiological characteristics of glutamate in the brain, glutamatergic abnormalities in depression andantidepressants acting on the glutamatergic system. References | Related Articles | Metrics

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Eph/ephrin Signaling Pathway in Brain Neurogenesis LIU Ting-ting, WANG Wen 2014, 4 (1):  25-28.  Abstract ( 4254 )   PDF (1032KB) ( 2681 )   Eph/ephrin is the largest subfamily of receptor tyrosine kinases, which participate in cell migration, axon guidance, angiogenesis and the formation of neural network in the development process. Eph/ephrin signaling pathway also plays an important role in neurogenesis and synaptic plasticity of adult nervous system. It has been suggested that neurogenesis can be enhanced after injury by regulating Eph/ephrin signaling pathway to improve neural function. This review summarized the effects of Eph/ephrin signaling pathway in subventricular zone (SVZ), subgranular zone (SGZ) and nonneurogenic central nervous system (CNS) regions, on neurogenesis, neuronal migration and synaptic plasticity, which provided an insight into developing effective neural repairment approaches. References | Related Articles | Metrics

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The Therapeutic Progress of Vascular Dementia in Terms of Modern Medicine and Chinese Traditional Treatment LIU Feng-xi, NIU Kai, XUE Gui-ping 2014, 4 (1):  29-33.  Abstract ( 2478 )   PDF (1002KB) ( 2651 )   Vascular dementia refers to a kind of cognitive dysfunction syndrome induced by cerebrovascular diseases and is one of important factors for mental disturbance and physical disability in modern society. In addition, VD, so far, is only avertable dementia type. If early diagnosis and effective therapy, the prognosis can be improved remarkably. The present paper reviewed the therapeutic progress in terms of modern medicine and Chinese traditional treatment. References | Related Articles | Metrics

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Effects of Sleep Deprivation on Learning and Memory and the Molecules In Central Nervous System GUO Xing-dao，LI Wei，ZHANG Guirong，ZHANG Dan-shen，CHENG Peng 2014, 4 (1):  34-51.  Abstract ( 4162 )   PDF (1239KB) ( 2824 )   Sleep deprivation(SD), a very common phenomenon in modern society, has been becoming one of the most significant medical problems because of its detrimental effects on human’s health. This paper reviewed the SD related studies in recent years and gave a brief summary on the research methods of SD and the effects of SD on learning and memory, with a particular focus on the changes of genes and proteins affected by SD in central nervous system. References | Related Articles | Metrics

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Protective Effects and Mechanisms of Chrysophanol in the Nervous System YAN Juan, ZHANG Dan-shen 2014, 4 (1):  52-57.  Abstract ( 3540 )   PDF (1037KB) ( 2725 )   Chrysophanol is an active component of the herbal medicine rhubarb (Rheum palmatum). Many researches have shown that chrysophanol has extensive bioactivity in cerebral ischemia-reperfusion injury and Alzheimer's disease. The neuroprotective mechanisms include antioxidant, AChE activity inhibition, brain amino acid modulation, brain tissue hypoxia tolerance enhancement, hippocampal neuron damage protection and neuronal apoptosis inhibition. It is a compound with a broad application potential. This paper mainly discussed the protective effects and mechanisms of chrysophanol in the nervous system. References | Related Articles | Metrics

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The Progress of Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) in Nervous System WANG Qi, WANG Hong-kai, RAN Jian-hua 2014, 4 (1):  58-64.  Abstract ( 3633 )   PDF (1052KB) ( 2312 )   As a major regulator of dephosphorylation of mitogen-activated protein kinases (MAPKs) which are importantsignal transduction pathways in organisms, mitogen-activated protein kinase phosphatase-1(MKP-1) plays a crucial role in various biological systems, including nervous system.This paper summarized the biological activity, regulation, new results and progress of MKP-1 in recent years, with a focus on the central nervous system. We proposed that MKP-1 is a drug target for future pharmacological research. References | Related Articles | Metrics