Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B

Abstract

Abstract: This paper reviewed the effect of Salvianolic acid-B (Sal B) on toxicity of amyloid β-protein (Aβ), tau protein and PC12 cells and SH-SY5Y cells apoptosis induced by Aβand tau protein, and on neurogenesis and angiogenesis．The results showed that Sal B could decrease the toxicity of Aβ by inhibiting Aβ aggregation and fibril formation, and protect cells damaged by Aβ．Hyperphosphoylation of tau protein could be attenuated by Sal B．Sal B has also been proved to promote neurogenesis and angiogenesis．Based on the neuroprotective effect of Sal B, it may be a potential medicine for treatment of neurodegenerative disease.

Key words: Salvianolic acid-B, amyloid-&, beta, tau protein, neurogenesis, angiogenesis

Tang Min-ke，Fan Yue，Liu Chang-suo，Zhang Jun-tian. Progress of The Mechanisms of Neuroprotective Effects of Salvianolic Acid B[J]. Acta Neuropharmacologica, 2014, 4(1): 1-10.

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