The Progress of Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) in Nervous System

Abstract

Abstract: As a major regulator of dephosphorylation of mitogen-activated protein kinases (MAPKs) which are importantsignal transduction pathways in organisms, mitogen-activated protein kinase phosphatase-1(MKP-1) plays a crucial role in
various biological systems, including nervous system.This paper summarized the biological activity, regulation, new results and progress of MKP-1 in recent years, with a focus on the central nervous system. We proposed that MKP-1 is a drug target for future pharmacological research.

Key words: MKP-1, MAPKs, dephosporylation, transcription, synaptic plasticity, repression
CNS inflammation

WANG Qi, WANG Hong-kai, RAN Jian-hua. The Progress of Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) in Nervous System[J]. ACTA NEUROPHARMACOLOGICA, 2014, 4(1): 58-64.

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